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Showing 1 to 6 of 6 entries
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Optogenetics for retinal disorders.

Journal of ophthalmic & vision research

Henriksen BS, Marc RE, Bernstein PS.
PMID: 25667740
J Ophthalmic Vis Res. 2014 Jul-Sep;9(3):374-82. doi: 10.4103/2008-322X.143379.

Optogenetics is the use of genetic methods combined with optical technology to achieve gain or loss of function within neuronal circuits. The field of optogenetics has been rapidly expanding in efforts to restore visual function to blinding diseases such...

AN OPTIMAL-PATH APPROACH FOR NEURAL CIRCUIT RECONSTRUCTION.

Proceedings. IEEE International Symposium on Biomedical Imaging

Jurrus E, Whitaker R, Jones BW, Marc R, Tasdizen T.
PMID: 19172170
Proc IEEE Int Symp Biomed Imaging. 2008 May;2008(4541320):1609-1612. doi: 10.1109/ISBI.2008.4541320.

Neurobiologists are collecting large amounts of electron microscopy image data to gain a better understanding of neuron organization in the central nervous system. Image analysis plays an important role in extracting the connectivity present in these images; however, due...

Peptide-based immunotherapy against oxidized elastin ameliorates pathology in mouse model of smoke-induced ocular injury.

Experimental eye research

Rohrer B, Parsons N, Annamalai B, Nicholson C, Obert E, Jones BW, Dick AD.
PMID: 34487725
Exp Eye Res. 2021 Nov;212:108755. doi: 10.1016/j.exer.2021.108755. Epub 2021 Sep 04.

PURPOSE: Age-related macular degeneration (AMD), the leading cause of blindness in western populations, is associated with an overactive complement system, and an increase in circulating antibodies against certain epitopes, including elastin. As loss of the elastin layer of Bruch's...

Graffinity: Visualizing Connectivity in Large Graphs.

Computer graphics forum : journal of the European Association for Computer Graphics

Kerzner E, Lex A, Sigulinsky CL, Umess T, Jones BW, Marc RE, Meyer M.
PMID: 29479126
Comput Graph Forum. 2017 Jun;36(3):251-260. doi: 10.1111/cgf.13184. Epub 2017 Jul 04.

Multivariate graphs are prolific across many fields, including transportation and neuroscience. A key task in graph analysis is the exploration of connectivity, to, for example, analyze how signals flow through neurons, or to explore how well different cities are...

Retinal Remodeling and Metabolic Alterations in Human AMD.

Frontiers in cellular neuroscience

Jones BW, Pfeiffer RL, Ferrell WD, Watt CB, Tucker J, Marc RE.
PMID: 27199657
Front Cell Neurosci. 2016 Apr 28;10:103. doi: 10.3389/fncel.2016.00103. eCollection 2016.

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in central visual field loss, ultimately causing debilitating blindness. AMD affects 18% of Americans from 65 to 74, 30% older than 74 years of age and is the leading...

ENHANCEMENT OF CELL BOUNDARIES IN TRANSMISSION ELECTRON MICROSCOPY IMAGES.

Proceedings. International Conference on Image Processing

Tasdizen T, Whitaker R, Marc R, Jones B.
PMID: 19169423
Proc Int Conf Image Proc. 2005;2:129-132. doi: 10.1109/ICIP.2005.1530008.

Transmission electron microscopy (TEM) is an important modality for the analysis of cellular structures in neurobiology. The computational analysis of neurons entail their segmentation and reconstruction from TEM images. This problem is complicated by the heavily textured nature of...

Showing 1 to 6 of 6 entries