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Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration.

Frontiers in aging neuroscience

Kincaid B, Bossy-Wetzel E.
PMID: 24046746
Front Aging Neurosci. 2013 Sep 06;5:48. doi: 10.3389/fnagi.2013.00048.

Caloric restriction (CR), fasting, and exercise have long been recognized for their neuroprotective and lifespan-extending properties; however, the underlying mechanisms of these phenomena remain elusive. Such extraordinary benefits might be linked to the activation of sirtuins. In mammals, the...

Common threads in neurodegenerative disorders of aging.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L.
PMID: 19595906
Alzheimers Dement. 2006 Oct;2(4):322-6. doi: 10.1016/j.jalz.2006.08.008.

No abstract available.

Clearing the brain's cobwebs: the role of autophagy in neuroprotection.

Current neuropharmacology

Bossy B, Perkins G, Bossy-Wetzel E.
PMID: 19305790
Curr Neuropharmacol. 2008 Jun;6(2):97-101. doi: 10.2174/157015908784533897.

Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates...

Showing 1 to 3 of 3 entries