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Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.

JCI insight

Ahadome SD, Mathew R, Reyes NJ, Mettu PS, Cousins SW, Calder VL, Saban DR.
PMID: 27595139
JCI Insight. 2016 Aug 04;1(12). doi: 10.1172/jci.insight.87012.

Fibrosis is a shared end-stage pathway to lung, liver, and heart failure. In the ocular mucosa (conjunctiva), fibrosis leads to blindness in trachoma, pemphigoid, and allergy. The indirect fibrogenic role of DCs via T cell activation and inflammatory cell...

Mucosal-associated invariant T cell responses differ by sex in COVID-19.

Med (New York, N.Y.)

Yu C, Littleton S, Giroux NS, Mathew R, Ding S, Kalnitsky J, Yang Y, Petzold E, Chung HA, Rivera GO, Rotstein T, Xi R, Ko ER, Tsalik EL, Sempowski GD, Denny TN, Burke TW, McClain MT, Woods CW, Shen X, Saban DR.
PMID: 33870241
Med (N Y). 2021 Jun 11;2(6):755-772.e5. doi: 10.1016/j.medj.2021.04.008. Epub 2021 Apr 13.

BACKGROUND: Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, but the mechanisms governing this disparity remain incompletely understood.METHODS: We carried out sex-balanced sampling of peripheral blood mononuclear cells from hospitalized and non-hospitalized individuals with confirmed...

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.

Blood

Jia W, Poe JC, Su H, Anand S, Matsushima GK, Rathmell JC, Maillard I, Radojcic V, Imai K, Reyes NJ, Cardona DM, Li Z, Suthers AN, Curry-Chisolm IM, DiCioccio RA, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S.
PMID: 33534893
Blood. 2021 May 06;137(18):2544-2557. doi: 10.1182/blood.2020008040.

Patients with chronic graft-versus-host disease (cGVHD) have increased B cell-activating factor (BAFF) levels, but whether BAFF promotes disease after allogeneic bone marrow transplantation (allo-BMT) remains unknown. In a major histocompatibility complex-mismatched model with cGVHD-like manifestations, we first examined B-lymphopenic...

Showing 1 to 3 of 3 entries