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Showing 1 to 12 of 13 entries
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Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration.

Translational vision science & technology

Tsikata E, Laíns I, Gil J, Marques M, Brown K, Mesquita T, Melo P, da Luz Cachulo M, Kim IK, Vavvas D, Murta JN, Miller JB, Silva R, Miller JW, Chen TC, Husain D.
PMID: 28316876
Transl Vis Sci Technol. 2017 Mar 13;6(2):3. doi: 10.1167/tvst.6.2.3. eCollection 2017 Mar.

PURPOSE: The purpose of this study was to develop an algorithm to automatically standardize the brightness, contrast, and color balance of digital color fundus photographs used to grade AMD and to validate this algorithm by determining the effects of...

Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa.

Cell death discovery

Murakami Y, Ikeda Y, Nakatake S, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Nakao S, Hisatomi T, Miller JW, Vavvas DG, Sonoda KH, Ishibashi T.
PMID: 27551484
Cell Death Discov. 2015 Nov 30;1:15058. doi: 10.1038/cddiscovery.2015.58. eCollection 2015.

Retinitis pigmentosa (RP) refers to a group of inherited retinal degenerations resulting form rod and cone photoreceptor cell death. The rod cell death due to deleterious genetic mutations has been shown to occur mainly through apoptosis, whereas the mechanisms...

Advances in Age-related Macular Degeneration Understanding and Therapy.

US ophthalmic review

Miller JW, Bagheri S, Vavvas DG.
PMID: 29142592
US Ophthalmic Rev. 2017;10(2):119-130. doi: 10.17925/USOR.2017.10.02.119.

While the development of anti-vascular endothelial growth factor (anti-VEGF) as a therapy for neovascular age-related macular degeneration (AMD) was a great success, the pathologic processes underlying dry AMD that eventually leads to photoreceptor dysfunction, death, and vision loss remain...

ALTITUDE-ASSOCIATED INTRAOCULAR PRESSURE CHANGES IN A GAS-FILLED EYE.

Retinal cases & brief reports

Foulsham W, Chen XN, Vavvas DG.
PMID: 30640814
Retin Cases Brief Rep. 2021 Sep 01;15(5):564-567. doi: 10.1097/ICB.0000000000000852.

PURPOSE: Intraocular gases are commonly used in vitreoretinal surgery. Patients are routinely advised against air travel before the complete absorption of intraocular gas. Consequently, reports on air travel in patients with large intraocular gas bubbles are highly unusual. Here,...

Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs.

BioResearch open access

Moos WH, Faller DV, Glavas IP, Harpp DN, Kanara I, Mavrakis AN, Pernokas J, Pernokas M, Pinkert CA, Powers WR, Sampani K, Steliou K, Vavvas DG, Zamboni RJ, Kodukula K, Chen X.
PMID: 32257625
Biores Open Access. 2020 Mar 31;9(1):94-105. doi: 10.1089/biores.2020.0004. eCollection 2020.

In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by acting on mitochondrial function,...

Percentage of Foveal vs Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-Related Macular Degeneration.

Journal of vitreoretinal diseases

Bagheri S, Lains I, Silverman RF, Kim I, Eliott D, Silva R, Miller J, Husain D, Miller JW, Saad L, Vavvas DG.
PMID: 31723722
J Vitreoretin Dis. 2019 Sep;3(5):278-282. doi: 10.1177/2474126419859454. Epub 2019 Aug 22.

PURPOSE: This article investigates the relationship between visual acuity (VA), total area of geographic atrophy (GA), and percentage of foveal GA.METHODS: A multicenter, retrospective, cross-sectional study was conducted of patients with GA due to age-related macular degeneration. Demographics, VA,...

Visualization of Choriocapillaris and Choroidal Vasculature in Healthy Eyes With En Face Swept-Source Optical Coherence Tomography Versus Angiography.

Translational vision science & technology

Wang JC, Laíns I, Silverman RF, Sobrin L, Vavvas DG, Miller JW, Miller JB.
PMID: 30598856
Transl Vis Sci Technol. 2018 Dec 20;7(6):25. doi: 10.1167/tvst.7.6.25. eCollection 2018 Nov.

PURPOSE: To compare the visualization of the choriocapillaris and deeper choroidal vessels in healthy eyes in en face swept-source optical coherence tomography (SS-OCT) versus SS-OCT angiography (SS-OCTA).METHODS: This is a cross-sectional study of consecutive eyes without chorioretinal disease. En...

A Drug Delivery System for Administration of Anti-TNF-α Antibody.

Translational vision science & technology

Robert MC, Frenette M, Zhou C, Yan Y, Chodosh J, Jakobiec FA, Stagner AM, Vavvas D, Dohlman CH, Paschalis EI.
PMID: 26981333
Transl Vis Sci Technol. 2016 Mar 11;5(2):11. doi: 10.1167/tvst.5.2.11. eCollection 2016 Mar.

PURPOSE: To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti-TNF-METHODS: A DDS was fabricated using inverse template fabrication of a hydrophobic three-dimensional porous scaffold (100-300 μm in diameter...

Modified Controlled Encircling Scleral Buckle for Retinal Detachment.

Journal of vitreoretinal diseases

Skondra D, Westerfeld C, Vavvas DG.
PMID: 29119143
J Vitreoretin Dis. 2017 Sep-Oct;1(5):314-316. doi: 10.1177/2474126417725218. Epub 2017 Aug 21.

During encircling scleral buckle placement, the ends of the element are tightened to achieve a shortened radius of the eye. The determining factor of the final buckle height is subjective using usually a combination of the buckle height visualized...

Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography.

Journal of vitreoretinal diseases

Diaz JD, Wang JC, Oellers P, Lains I, Sobrin L, Husain D, Miller JW, Vavvas DG, Miller JB.
PMID: 29930992
J Vitreoretin Dis. 2018 May-Jun;2(3):146-154. doi: 10.1177/2474126418771805. Epub 2018 Apr 16.

PURPOSE: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA.METHODS: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue...

Paediatric ocular adnexal lymphoma: a population-based analysis.

BMJ open ophthalmology

Moustafa GA, Topham AK, Aronow ME, Vavvas DG.
PMID: 32596505
BMJ Open Ophthalmol. 2020 Jun 21;5(1):e000483. doi: 10.1136/bmjophth-2020-000483. eCollection 2020.

OBJECTIVE: To investigate the incidence, clinicopathological characteristics and survival of ocular adnexal lymphoma (OAL) in the paediatric population.METHODS AND ANALYSIS: In this retrospective case series, the Surveillance, Epidemiology and End Results database was accessed to identify individuals with OAL...

Optic Disk Pit with Sudden Central Visual Field Scotoma.

Case reports in ophthalmological medicine

Panou N, Vavvas DG.
PMID: 27872777
Case Rep Ophthalmol Med. 2016;2016:1423481. doi: 10.1155/2016/1423481. Epub 2016 Oct 31.

No abstract available.

Showing 1 to 12 of 13 entries