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The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation.

Journal of experimental pharmacology

Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF.
PMID: 20865058
J Exp Pharmacol. 2010 Jul;2010(2):83-91. doi: 10.2147/JEP.S11719.

BACKGROUND: Cranberry products have been implicated in several case reports to enhance the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic CYP2C9-mediated metabolic clearance of warfarin by components in cranberry. Because dietary/natural substances vary substantially...

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