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Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption.

Frontiers in physiology

Chi OZ, Liu X, Cofano S, Patel N, Jacinto E, Weiss HR.
PMID: 34354602
Front Physiol. 2021 Jul 20;12:706528. doi: 10.3389/fphys.2021.706528. eCollection 2021.

It has been reported that the mechanistic target of rapamycin (mTOR) pathway is involved in cerebral ischemia-reperfusion injury. One of the important pathological changes during reperfusion after cerebral ischemia is disruption of blood-brain barrier (BBB). Rapamycin, a first-generation mTOR...

Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption.

Neuroscience letters

Chi OZ, Chiricolo A, Liu X, Patel N, Jacinto E, Weiss HR.
PMID: 34332027
Neurosci Lett. 2021 Sep 25;762:136143. doi: 10.1016/j.neulet.2021.136143. Epub 2021 Jul 29.

Blood-brain barrier (BBB) disruption is one of the most important pathological changes following cerebral ischemia-reperfusion. We tested whether inhibition of the serum and glucocorticoid regulated kinase 1 (SGK1) would decrease BBB disruption and contribute to decreasing infarct size in...

Showing 1 to 2 of 2 entries