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Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Frontiers in neuroscience

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.
PMID: 26941593
Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.

Breakthrough advances in intravital imaging have launched a new era for the study of dynamic interactions at the neurovascular interface in health and disease. The first Neurovascular and Immuno-Imaging Symposium was held at the Gladstone Institutes, University of California,...

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Akassoglou K, Agalliu D, Chang CJ, et al. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016;10:46doi: 10.3389/fnins.2016.00046.
Akassoglou, K., Agalliu, D., Chang, C. J., Davalos, D., Grutzendler, J., Hillman, E. M., Khakh, B. S., Kleinfeld, D., McGavern, D. B., Nelson, S. J., & Zlokovic, B. V. (2016). Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Frontiers in neuroscience, 1046. https://doi.org/10.3389/fnins.2016.00046
Akassoglou, Katerina, et al. "Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium." Frontiers in neuroscience vol. 10 (2016): 46. doi: https://doi.org/10.3389/fnins.2016.00046
Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016. PMID: 26941593; PMCID: PMC4761864.
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A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells.

Chemical science

Brewer TF, Burgos-Barragan G, Wit N, Patel KJ, Chang CJ.
PMID: 28580121
Chem Sci. 2017 May 01;8(5):4073-4081. doi: 10.1039/c7sc00748e. Epub 2017 Apr 07.

Formaldehyde (FA) is a major reactive carbonyl species (RCS) that is naturally produced in living systems through a diverse array of cellular pathways that span from epigenetic regulation to the metabolic processing of endogenous metabolites. At the same time,...

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Brewer TF, Burgos-Barragan G, Wit N, et al. A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chem Sci. 2017;8(5):4073-4081doi: 10.1039/c7sc00748e.
Brewer, T. F., Burgos-Barragan, G., Wit, N., Patel, K. J., & Chang, C. J. (2017). A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chemical science, 8(5), 4073-4081. https://doi.org/10.1039/c7sc00748e
Brewer, Thomas F, et al. "A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells." Chemical science vol. 8,5 (2017): 4073-4081. doi: https://doi.org/10.1039/c7sc00748e
Brewer TF, Burgos-Barragan G, Wit N, Patel KJ, Chang CJ. A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells. Chem Sci. 2017 May 01;8(5):4073-4081. doi: 10.1039/c7sc00748e. Epub 2017 Apr 07. PMID: 28580121; PMCID: PMC5434806.
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A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells.

Bioorganic & medicinal chemistry letters

Jia S, Chang CJ.
PMID: 34245851
Bioorg Med Chem Lett. 2021 Sep 15;48:128252. doi: 10.1016/j.bmcl.2021.128252. Epub 2021 Jul 07.

Hydrogen peroxide (H

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Jia S, Chang CJ. A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells. Bioorg Med Chem Lett. 2021;48:128252doi: 10.1016/j.bmcl.2021.128252.
Jia, S., & Chang, C. J. (2021). A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells. Bioorganic & medicinal chemistry letters, 48128252. https://doi.org/10.1016/j.bmcl.2021.128252
Jia, Shang, and Chang, Christopher J. "A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells." Bioorganic & medicinal chemistry letters vol. 48 (2021): 128252. doi: https://doi.org/10.1016/j.bmcl.2021.128252
Jia S, Chang CJ. A microtubule-localizing activity-based sensing fluorescent probe for imaging hydrogen peroxide in living cells. Bioorg Med Chem Lett. 2021 Sep 15;48:128252. doi: 10.1016/j.bmcl.2021.128252. Epub 2021 Jul 07. PMID: 34245851; PMCID: PMC8556696.
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Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems.

Israel journal of chemistry

Ramos-Torres KM, Kolemen S, Chang CJ.
PMID: 31263315
Isr J Chem. 2016 Oct 01;56(9):724-737. doi: 10.1002/ijch.201600023. Epub 2016 Jul 25.

Copper is an essential element in biological systems. Its potent redox activity renders it necessary for life, but at the same time, misregulation of its cellular pools can lead to oxidative stress implicated in aging and various disease states....

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Ramos-Torres KM, Kolemen S, Chang CJ. Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Isr J Chem. 2016;56(9):724-737doi: 10.1002/ijch.201600023.
Ramos-Torres, K. M., Kolemen, S., & Chang, C. J. (2016). Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Israel journal of chemistry, 56(9), 724-737. https://doi.org/10.1002/ijch.201600023
Ramos-Torres, Karla M, et al. "Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems." Israel journal of chemistry vol. 56,9 (2016): 724-737. doi: https://doi.org/10.1002/ijch.201600023
Ramos-Torres KM, Kolemen S, Chang CJ. Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems. Isr J Chem. 2016 Oct 01;56(9):724-737. doi: 10.1002/ijch.201600023. Epub 2016 Jul 25. PMID: 31263315; PMCID: PMC6602089.
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A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells.

Chemical science

Wang Z, Detomasi TC, Chang CJ.
PMID: 34163931
Chem Sci. 2020 Dec 15;12(5):1720-1729. doi: 10.1039/d0sc03844j.

Potassium is the most abundant intracellular metal in the body, playing vital roles in regulating intracellular fluid volume, nutrient transport, and cell-to-cell communication through nerve and muscle contraction. On the other hand, aberrant alterations in K

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Wang Z, Detomasi TC, Chang CJ. A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci. 2020;12(5):1720-1729doi: 10.1039/d0sc03844j.
Wang, Z., Detomasi, T. C., & Chang, C. J. (2020). A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chemical science, 12(5), 1720-1729. https://doi.org/10.1039/d0sc03844j
Wang, Zeming, et al. "A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells." Chemical science vol. 12,5 (2020): 1720-1729. doi: https://doi.org/10.1039/d0sc03844j
Wang Z, Detomasi TC, Chang CJ. A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci. 2020 Dec 15;12(5):1720-1729. doi: 10.1039/d0sc03844j. PMID: 34163931; PMCID: PMC8179100.
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A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model.

Chemical science

Que EL, New EJ, Chang CJ.
PMID: 25431649
Chem Sci. 2012 Jun 01;3(6):1829-1834. doi: 10.1039/C2SC20273E. Epub 2012 Apr 18.

We present the synthesis and characterization of octaarginine-conjugated Copper-Gad-2 (Arg

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Que EL, New EJ, Chang CJ. A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chem Sci. 2012;3(6):1829-1834doi: 10.1039/C2SC20273E.
Que, E. L., New, E. J., & Chang, C. J. (2012). A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chemical science, 3(6), 1829-1834. https://doi.org/10.1039/C2SC20273E
Que, Emily L, et al. "A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model." Chemical science vol. 3,6 (2012): 1829-1834. doi: https://doi.org/10.1039/C2SC20273E
Que EL, New EJ, Chang CJ. A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chem Sci. 2012 Jun 01;3(6):1829-1834. doi: 10.1039/C2SC20273E. Epub 2012 Apr 18. PMID: 25431649; PMCID: PMC4243178.
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An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters.

ACS central science

Ohata J, Krishnamoorthy L, Gonzalez MA, Xiao T, Iovan DA, Toste FD, Miller EW, Chang CJ.
PMID: 31989024
ACS Cent Sci. 2020 Jan 22;6(1):32-40. doi: 10.1021/acscentsci.9b01038. Epub 2020 Jan 07.

Chemical probes that report on protein activity, rather than protein abundance, with spatial and temporal resolution can enable studies of their native function in biological contexts as well as provide opportunities for developing new types of biochemical reporters. Here...

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Ohata J, Krishnamoorthy L, Gonzalez MA, et al. An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters. ACS Cent Sci. 2020;6(1):32-40doi: 10.1021/acscentsci.9b01038.
Ohata, J., Krishnamoorthy, L., Gonzalez, M. A., Xiao, T., Iovan, D. A., Toste, F. D., Miller, E. W., & Chang, C. J. (2020). An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters. ACS central science, 6(1), 32-40. https://doi.org/10.1021/acscentsci.9b01038
Ohata, Jun, et al. "An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters." ACS central science vol. 6,1 (2020): 32-40. doi: https://doi.org/10.1021/acscentsci.9b01038
Ohata J, Krishnamoorthy L, Gonzalez MA, Xiao T, Iovan DA, Toste FD, Miller EW, Chang CJ. An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters. ACS Cent Sci. 2020 Jan 22;6(1):32-40. doi: 10.1021/acscentsci.9b01038. Epub 2020 Jan 07. PMID: 31989024; PMCID: PMC6978837.
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Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.

Nature

Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ.
PMID: 29411778
Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23904. Epub 2017 Aug 23.

This corrects the article DOI: 10.1038/nature23481.

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Burgos-Barragan G, Wit N, Meiser J, et al. Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature. 2017;548(7669):612doi: 10.1038/nature23904.
Burgos-Barragan, G., Wit, N., Meiser, J., Dingler, F. A., Pietzke, M., Mulderrig, L., Pontel, L. B., Rosado, I. V., Brewer, T. F., Cordell, R. L., Monks, P. S., Chang, C. J., Vazquez, A., & Patel, K. J. (2017). Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature, 548(7669), 612. https://doi.org/10.1038/nature23904
Burgos-Barragan, Guillermo, et al. "Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism." Nature vol. 548,7669 (2017): 612. doi: https://doi.org/10.1038/nature23904
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ. Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23904. Epub 2017 Aug 23. PMID: 29411778; PMCID: PMC7050999.
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A reactivity-based [.

Chemical science

Liu W, Truillet C, Flavell RR, Brewer TF, Evans MJ, Wilson DM, Chang CJ.
PMID: 30034690
Chem Sci. 2016 Aug 01;7(8):5503-5507. doi: 10.1039/c6sc01503d. Epub 2016 May 25.

Formaldehyde (FA) is a reactive carbonyl species (RCS) that plays a broad spectrum of roles in epigenetics, toxicology, and progression of diseases ranging from cancer to diabetes to neurodegeneration, motivating the development of translatable technologies for FA imaging. Here...

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Liu W, Truillet C, Flavell RR, et al. A reactivity-based [. Chem Sci. 2016;7(8):5503-5507doi: 10.1039/c6sc01503d.
Liu, W., Truillet, C., Flavell, R. R., Brewer, T. F., Evans, M. J., Wilson, D. M., & Chang, C. J. (2016). A reactivity-based [. Chemical science, 7(8), 5503-5507. https://doi.org/10.1039/c6sc01503d
Liu, Wei, et al. "A reactivity-based [." Chemical science vol. 7,8 (2016): 5503-5507. doi: https://doi.org/10.1039/c6sc01503d
Liu W, Truillet C, Flavell RR, Brewer TF, Evans MJ, Wilson DM, Chang CJ. A reactivity-based [. Chem Sci. 2016 Aug 01;7(8):5503-5507. doi: 10.1039/c6sc01503d. Epub 2016 May 25. PMID: 30034690; PMCID: PMC6021783.
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Showing 1 to 9 of 9 entries