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Cilia in autophagy and cancer.

Cilia

Cao M, Zhong Q.
PMID: 26848389
Cilia. 2016 Feb 03;5:4. doi: 10.1186/s13630-016-0027-3. eCollection 2015.

Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental...

Prefused lysosomes cluster on autophagosomes regulated by VAMP8.

Cell death & disease

Chen Q, Hao M, Wang L, Li L, Chen Y, Shao X, Tian Z, Pfuetzner RA, Zhong Q, Brunger AT, Guan JL, Diao J.
PMID: 34645799
Cell Death Dis. 2021 Oct 13;12(10):939. doi: 10.1038/s41419-021-04243-0.

Lysosome-autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been identified, the prefusion architecture and its regulation remain unclear. Herein, we show that upon stimulation, multiple lysosomes form clusters around individual autophagosomes,...

Showing 1 to 2 of 2 entries