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Showing 1 to 10 of 10 entries
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Macroautophagy and aging: The impact of cellular recycling on health and longevity.

Molecular aspects of medicine

Nieto-Torres JL, Hansen M.
PMID: 34507801
Mol Aspects Med. 2021 Dec;82:101020. doi: 10.1016/j.mam.2021.101020. Epub 2021 Sep 07.

Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy....

LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus.

Autophagy

Nieto-Torres JL, Encalada SE, Hansen M.
PMID: 34424150
Autophagy. 2021 Oct;17(10):3266-3268. doi: 10.1080/15548627.2021.1961073. Epub 2021 Aug 23.

Macroautophagy/autophagy is a multi-step process that leads to cargo degradation via the fusion of hydrolases-containing lysosomes with cargo-loaded autophagosomes. For this process to occur, autophagosomes are directionally transported by molecular motors toward the nucleus, where they fuse with lysosomes...

Autophagy in healthy aging and disease.

Nature aging

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF.
PMID: 34901876
Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.

Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship...

Macroautophagy and aging: The impact of cellular recycling on health and longevity.

Molecular aspects of medicine

Nieto-Torres JL, Hansen M.
PMID: 34507801
Mol Aspects Med. 2021 Dec;82:101020. doi: 10.1016/j.mam.2021.101020. Epub 2021 Sep 07.

Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy....

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Current biology : CB

Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Verhelle A, Encalada SE, Hansen M.
PMID: 34146484
Curr Biol. 2021 Aug 09;31(15):3440-3449.e7. doi: 10.1016/j.cub.2021.05.052. Epub 2021 Jun 18.

Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo. During autophagy, cargo is sequestered into double-membrane vesicles called autophagosomes, which are predominantly transported in...

Beth Levine in memoriam.

Autophagy

[No authors listed]
PMID: 32722983
Autophagy. 2020 Sep;16(9):1559-1583. doi: 10.1080/15548627.2020.1787721. Epub 2020 Jul 29.

No abstract available.

Macroautophagy and aging: The impact of cellular recycling on health and longevity.

Molecular aspects of medicine

Nieto-Torres JL, Hansen M.
PMID: 34507801
Mol Aspects Med. 2021 Dec;82:101020. doi: 10.1016/j.mam.2021.101020. Epub 2021 Sep 07.

Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy....

Macroautophagy and aging: The impact of cellular recycling on health and longevity.

Molecular aspects of medicine

Nieto-Torres JL, Hansen M.
PMID: 34507801
Mol Aspects Med. 2021 Dec;82:101020. doi: 10.1016/j.mam.2021.101020. Epub 2021 Sep 07.

Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy....

Autophagy as a promoter of longevity: insights from model organisms.

Nature reviews. Molecular cell biology

Hansen M, Rubinsztein DC, Walker DW.
PMID: 30006559
Nat Rev Mol Cell Biol. 2018 Sep;19(9):579-593. doi: 10.1038/s41580-018-0033-y.

Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade indicates that autophagy also has...

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Current biology : CB

Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Verhelle A, Encalada SE, Hansen M.
PMID: 34146484
Curr Biol. 2021 Aug 09;31(15):3440-3449.e7. doi: 10.1016/j.cub.2021.05.052. Epub 2021 Jun 18.

Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo. During autophagy, cargo is sequestered into double-membrane vesicles called autophagosomes, which are predominantly transported in...

Showing 1 to 10 of 10 entries