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Showing 1 to 12 of 12 entries
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Education, Smoking, and Cohort Change: Forwarding a Multidimensional Theory of the Environmental Moderation of Genetic Effects.

American sociological review

Wedow R, Zacher M, Huibregtse BM, Harris KM, Domingue BW, Boardman JD.
PMID: 31534265
Am Sociol Rev. 2018 Aug;83(4):802-832. doi: 10.1177/0003122418785368. Epub 2018 Jul 20.

We introduce a genetic correlation by environment interaction model [(rG)xE] which allows for social environmental moderation of the genetic relationship between two traits. To empirically demonstrate the significance of the (rG)xE perspective, we use genome wide information from respondents...

Schools as Moderators of Genetic Associations with Life Course Attainments: Evidence from the WLS and Add Health.

Sociological science

Trejo S, Belsky DW, Boardman JD, Freese J, Harris KM, Herd P, Sicinski K, Domingue BW.
PMID: 30613760
Sociol Sci. 2018 Aug;5:513-540. doi: 10.15195/v5.a22. Epub 2018 Aug 02.

Genetic variants identified in genome-wide association studies of educational attainment have been linked with a range of positive life course development outcomes. However, it remains unclear whether school environments may moderate these genetic associations. We analyze data from two...

Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Wide educational disparities in young adult cardiovascular health.

SSM - population health

Lawrence EM, Hummer RA, Domingue BW, Harris KM.
PMID: 30094320
SSM Popul Health. 2018 Jul 20;5:249-256. doi: 10.1016/j.ssmph.2018.07.006. eCollection 2018 Aug.

Widening educational differences in overall health and recent stagnation in cardiovascular disease mortality rates highlight the critical need to describe and understand educational disparities in cardiovascular health (CVH) among U.S. young adults. We use two data sets representative of...

Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Polygenic Influence on Educational Attainment: New evidence from The National Longitudinal Study of Adolescent to Adult Health.

AERA open

Domingue BW, Belsky D, Conley D, Harris KM, Boardman JD.
PMID: 28164148
AERA Open. 2015 Jul-Sep;1(3):1-13. doi: 10.1177/2332858415599972. Epub 2015 Aug 19.

Recent studies have begun to uncover the genetic architecture of educational attainment. We build on this work using genome-wide data from siblings in the National Longitudinal Study of Adolescent to Adult Health (Add Health). We measure the genetic predisposition...

Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Jun 17; doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health.

Nutrition & diabetes

Graff M, North KE, Mohlke KL, Lange LA, Luo J, Harris KM, Young KL, Richardson AS, Lange EM, Gordon-Larsen P.
PMID: 23168566
Nutr Diabetes. 2012 Sep 24;2:e47. doi: 10.1038/nutd.2012.20.

OBJECTIVE: The contribution of genetic variants to body mass index (BMI) during adolescence across multiethnic samples is largely unknown. We selected genetic loci associated with BMI or obesity in European-descent samples and examined them in a multiethnic adolescent sample.DESIGN...

PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics.

Genome biology

Zhao Z, Yi Y, Song J, Wu Y, Zhong X, Lin Y, Hohman TJ, Fletcher J, Lu Q.
PMID: 34488838
Genome Biol. 2021 Sep 06;22(1):257. doi: 10.1186/s13059-021-02479-9.

Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune...

Genome-wide stress sensitivity moderates the stress-depression relationship in a nationally representative sample of adults.

Scientific reports

Davidson T, Braudt DB, Keers R, Assary E, Harris KM, Boardman JD.
PMID: 34645846
Sci Rep. 2021 Oct 13;11(1):20332. doi: 10.1038/s41598-021-98684-4.

We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and depression is...

Showing 1 to 12 of 12 entries