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Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

BioData mining

Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, Riess H, Sivapalaratnam S, Tragante V, van Iperen EPA, Brautbar A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Larson EB, Rasmussen-Torvik LJ, Tromp G, Baumert J, Cruickshanks KJ, Farrall M, Hingorani AD, Hovingh GK, Kleber ME, Klein BE, Klein R, Koenig W, Lange LA, Mӓrz W, North KE, Charlotte Onland-Moret N, Reiner AP, Talmud PJ, van der Schouw YT, Wilson JG, Kivimaki M, Kumari M, Moore JH, Drenos F, Asselbergs FW, Keating BJ, Ritchie MD.
PMID: 28770004
BioData Min. 2017 Jul 24;10:25. doi: 10.1186/s13040-017-0145-5. eCollection 2017.

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol...

Dietary inflammatory index and recurrence of depressive symptoms: Results from the Whitehall II Study.

Clinical psychological science : a journal of the Association for Psychological Science

Akbaraly T, Kerlau C, Wyart M, Chevallier N, Ndiaye L, Shivappa N, Hébert JR, Kivimäki M.
PMID: 28070452
Clin Psychol Sci. 2016 Nov;4(6):1125-1134. doi: 10.1177/2167702616645777. Epub 2016 Aug 08.

There is a growing interest in understanding the role of inflammation in diet-depression relationship. The present study examined whether the dietary inflammatory index (DII, a measure of the inflammatory potential of individuals' diets) is associated with recurrent depressive symptoms...

Little Change in Diet After Onset of Type 2 Diabetes, Metabolic Syndrome, and Obesity in Middle-Aged Adults: 11-Year Follow-up Study.

Diabetes care

Akbaraly TN, Tabak AG, Shipley MJ, Mura T, Singh-Manoux A, Ferrie JE, Batty GD, Kivimaki M.
PMID: 26740640
Diabetes Care. 2016 Mar;39(3):e29-30. doi: 10.2337/dc15-2094. Epub 2016 Jan 06.

No abstract available.

The Long Reach of Childhood Health and Circumstance: Evidence from the Whitehall II Study.

Economic journal (London, England)

Case A, Paxson C.
PMID: 22228912
Econ J (London). 2011 Aug;121(554):F183-F204. doi: 10.1111/j.1468-0297.2011.02447.x.

We use data from the Whitehall II Study to examine the joint evolution of health status and economic status over the life course. We study the links between health and socioeconomic status in childhood and health and employment status...

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men.

PloS one

Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D, Rapsomaniki E, Pujades-Rodriguez M, Denaxas S, Udumyan R, Kivimaki M, Hemingway H.
PMID: 27105076
PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016.

BACKGROUND: Depression is associated with coronary heart disease and stroke, but associations with a range of pathologically diverse cardiovascular diseases are not well understood. We examine the risk of 12 cardiovascular diseases according to depression status (history or new...

Cognition and incident coronary heart disease in late midlife: The Whitehall II study.

Intelligence

Singh-Manoux A, Sabia S, Kivimaki M, Shipley MJ, Ferrie JE, Marmot MG.
PMID: 20161539
Intelligence. 2009 Nov 01;37(6):529-534. doi: 10.1016/j.intell.2008.12.001.

The purpose of this study was to investigate whether cognitive function in midlife predicts incident coronary heart disease (CHD), followed up over 6 years. Data on 5292 (28% women, mean age 55) individuals free from CHD at baseline were...

Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies.

Diabetes care

Pan A, Keum N, Okereke OI, Sun Q, Kivimaki M, Rubin RR, Hu FB.
PMID: 22517938
Diabetes Care. 2012 May;35(5):1171-80. doi: 10.2337/dc11-2055.

OBJECTIVE: Epidemiological studies have repeatedly investigated the association between depression and metabolic syndrome (MetS). However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association.RESEARCH DESIGN...

Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

International journal of obesity (2005)

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C.
PMID: 33446837
Int J Obes (Lond). 2021 Apr;45(4):758-765. doi: 10.1038/s41366-020-00735-9. Epub 2021 Jan 14.

BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed...

Showing 1 to 10 of 10 entries