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Showing 1 to 12 of 18 entries
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The janus head of T cell aging - autoimmunity and immunodeficiency.

Frontiers in immunology

Goronzy JJ, Li G, Yang Z, Weyand CM.
PMID: 23761790
Front Immunol. 2013 Jun 04;4:131. doi: 10.3389/fimmu.2013.00131. eCollection 2013.

Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence...

Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

European journal of rheumatology

Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM.
PMID: 31329543
Eur J Rheumatol. 2019 Jul 19;6(4):199-206. doi: 10.5152/eurjrheum.2019.18215. Print 2019 Oct.

OBJECTIVE: Behçet's disease (BD) is a rare vasculitis that results in multi-organ inflammatory disease. At-risk populations are most prevalent in the Middle East and East Asia. Clinical data on BD in Western countries, especially in the United States, are...

Metabolic Fitness of T Cells in Autoimmune Disease.

Immunometabolism

Wu B, Goronzy JJ, Weyand CM.
PMID: 32477606
Immunometabolism. 2020;2(2). doi: 10.20900/immunometab20200017. Epub 2020 Apr 22.

Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common autoimmune diseases, often considered prototypic examples for how protective immunity switches to destructive immunity. The autoantigens recognized in RA and SLE are distinct, clinical manifestations are partially overlapping....

Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Dec;288(24):7123-7142. doi: 10.1111/febs.15770. Epub 2021 Mar 03.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

T cell-macrophage interactions and granuloma formation in vasculitis.

Frontiers in immunology

Hilhorst M, Shirai T, Berry G, Goronzy JJ, Weyand CM.
PMID: 25309534
Front Immunol. 2014 Sep 12;5:432. doi: 10.3389/fimmu.2014.00432. eCollection 2014.

Granuloma formation, bringing into close proximity highly activated macrophages and T cells, is a typical event in inflammatory blood vessel diseases, and is noted in the name of several of the vasculitides. It is not known whether specific properties...

Finding Balance: T cell Regulatory Receptor Expression during Aging.

Aging and disease

Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ.
PMID: 22396890
Aging Dis. 2011 Oct;2(5):398-413. Epub 2011 Oct 28.

Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of...

Hallmarks of the aging T-cell system.

The FEBS journal

Zhang H, Weyand CM, Goronzy JJ.
PMID: 33590946
FEBS J. 2021 Feb 16; doi: 10.1111/febs.15770. Epub 2021 Feb 16.

The adaptive immune system has the enormous challenge to protect the host through the generation and differentiation of pathogen-specific short-lived effector T cells while in parallel developing long-lived memory cells to control future encounters with the same pathogen. A...

Telomere dysfunction, autoimmunity and aging.

Aging and disease

Hohensinner PJ, Goronzy JJ, Weyand CM.
PMID: 22396899
Aging Dis. 2011 Dec;2(6):524-37. Epub 2011 Dec 02.

Immune aging is associated with loss of critical immune functions, such as host protection from infection and malignancy. Unexpectedly, immunosenescence also renders the host susceptible to inflammation, which may translate into tissue-damaging disease as the senescent immune system loses...

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

The Journal of clinical investigation

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG.
PMID: 27035819
J Clin Invest. 2016 Apr 01;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 01.

No abstract available.

Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions.

International journal of clinical rheumatology

Hong J, Maron DJ, Shirai T, Weyand CM.
PMID: 27042216
Int J Clin Rheumtol. 2015 Oct;10(5):365-381. doi: 10.2217/ijr.15.33.

Atherosclerosis is a complex inflammatory disease involving aberrant immune and tissue healing responses, which begins with endothelial dysfunction and ends with plaque development, instability and rupture. The increased risk for coronary artery disease in patients with rheumatologic diseases highlights...

Giant Cell Arteritis: From Pathogenesis to Therapeutic Management.

Current treatment options in rheumatology

Watanabe R, Goronzy JJ, Berry G, Liao YJ, Weyand CM.
PMID: 27298757
Curr Treatm Opt Rheumatol. 2016 Jun;2(2):126-137. doi: 10.1007/s40674-016-0043-x. Epub 2016 Apr 11.

No abstract available.

Showing 1 to 12 of 18 entries