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An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.

Human molecular genetics

Sun P, Zhou W, Fu Y, Cheung CYY, Dong Y, Yang ML, Zhang H, Jia J, Huo Y, Willer CJ, Chen YE, Tang CS, Tse HF, Lam KSL, Gao W, Xu M, Yu H, Sham PC, Zhang Y, Ganesh SK.
PMID: 33693786
Hum Mol Genet. 2021 May 28;30(9):836-842. doi: 10.1093/hmg/ddab062.

Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European ancestry. We sought to conduct unbiased genetic discovery for coding variants that influence hematological traits in a Han Chinese population....

Cite
Sun P, Zhou W, Fu Y, et al. An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Hum Mol Genet. 2021;30(9):836-842doi: 10.1093/hmg/ddab062.
Sun, P., Zhou, W., Fu, Y., Cheung, C. Y. Y., Dong, Y., Yang, M. L., Zhang, H., Jia, J., Huo, Y., Willer, C. J., Chen, Y. E., Tang, C. S., Tse, H. F., Lam, K. S. L., Gao, W., Xu, M., Yu, H., Sham, P. C., Zhang, Y., & Ganesh, S. K. (2021). An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Human molecular genetics, 30(9), 836-842. https://doi.org/10.1093/hmg/ddab062
Sun, Pengfei, et al. "An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population." Human molecular genetics vol. 30,9 (2021): 836-842. doi: https://doi.org/10.1093/hmg/ddab062
Sun P, Zhou W, Fu Y, Cheung CYY, Dong Y, Yang ML, Zhang H, Jia J, Huo Y, Willer CJ, Chen YE, Tang CS, Tse HF, Lam KSL, Gao W, Xu M, Yu H, Sham PC, Zhang Y, Ganesh SK. An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Hum Mol Genet. 2021 May 28;30(9):836-842. doi: 10.1093/hmg/ddab062. PMID: 33693786; PMCID: PMC8161516.
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Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

American journal of human genetics

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG.
PMID: 27588453
Am J Hum Genet. 2016 Sep 01;99(3):785. doi: 10.1016/j.ajhg.2016.08.002. Epub 2016 Sep 01.

No abstract available.

Cite
Polfus LM, Khajuria RK, Schick UM, et al. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016;99(3):785doi: 10.1016/j.ajhg.2016.08.002.
Polfus, L. M., Khajuria, R. K., Schick, U. M., Pankratz, N., Pazoki, R., Brody, J. A., Chen, M. H., Auer, P. L., Floyd, J. S., Huang, J., Lange, L., van Rooij, F. J. A., Gibbs, R. A., Metcalf, G., Muzny, D., Veeraraghavan, N., Walter, K., Chen, L., Yanek, L., Becker, L. C., Peloso, G. M., Wakabayashi, A., Kals, M., Metspalu, A., Esko, T., Fox, K., Wallace, R., Franceschini, N., Matijevic, N., Rice, K. M., Bartz, T. M., Lyytikäinen, L. P., Kähönen, M., Lehtimäki, T., Raitakari, O. T., Li-Gao, R., Mook-Kanamori, D. O., Lettre, G., van Duijn, C. M., Franco, O. H., Rich, S. S., Rivadeneira, F., Hofman, A., Uitterlinden, A. G., Wilson, J. G., Psaty, B. M., Soranzo, N., Dehghan, A., Boerwinkle, E., Zhang, X., Johnson, A. D., O'Donnell, C. J., Johnsen, J. M., Reiner, A. P., Ganesh, S. K., & Sankaran, V. G. (2016). Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. American journal of human genetics, 99(3), 785. https://doi.org/10.1016/j.ajhg.2016.08.002
Polfus, Linda M, et al. "Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis." American journal of human genetics vol. 99,3 (2016): 785. doi: https://doi.org/10.1016/j.ajhg.2016.08.002
Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016 Sep 01;99(3):785. doi: 10.1016/j.ajhg.2016.08.002. Epub 2016 Sep 01. PMID: 27588453; PMCID: PMC5011073.
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Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease.

Hypertension (Dallas, Tex. : 1979)

Sun P, Kumar N, Tin A, Zhao J, Brown MR, Lin Z, Yang ML, Zheng Q, Jia J, Bielak LF, Yu B, Boerwinkle E, Hunker KL, Coresh J, Chen YE, Huo Y, Kardia SLR, Khoriaty R, Zhou X, Morrison AC, Zhang Y, Ganesh SK.
PMID: 34488438
Hypertension. 2021 Nov;78(5):1555-1566. doi: 10.1161/HYPERTENSIONAHA.121.17597. Epub 2021 Sep 07.

[Figure: see text].

Cite
Sun P, Kumar N, Tin A, et al. Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension. 2021;78(5):1555-1566doi: 10.1161/HYPERTENSIONAHA.121.17597.
Sun, P., Kumar, N., Tin, A., Zhao, J., Brown, M. R., Lin, Z., Yang, M. L., Zheng, Q., Jia, J., Bielak, L. F., Yu, B., Boerwinkle, E., Hunker, K. L., Coresh, J., Chen, Y. E., Huo, Y., Kardia, S. L. R., Khoriaty, R., Zhou, X., Morrison, A. C., Zhang, Y., & Ganesh, S. K. (2021). Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension (Dallas, Tex. : 1979), 78(5), 1555-1566. https://doi.org/10.1161/HYPERTENSIONAHA.121.17597
Sun, Pengfei, et al. "Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease." Hypertension (Dallas, Tex. : 1979) vol. 78,5 (2021): 1555-1566. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17597
Sun P, Kumar N, Tin A, Zhao J, Brown MR, Lin Z, Yang ML, Zheng Q, Jia J, Bielak LF, Yu B, Boerwinkle E, Hunker KL, Coresh J, Chen YE, Huo Y, Kardia SLR, Khoriaty R, Zhou X, Morrison AC, Zhang Y, Ganesh SK. Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension. 2021 Nov;78(5):1555-1566. doi: 10.1161/HYPERTENSIONAHA.121.17597. Epub 2021 Sep 07. PMID: 34488438; PMCID: PMC8516734.
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An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.

Human molecular genetics

Sun P, Zhou W, Fu Y, Cheung CYY, Dong Y, Yang ML, Zhang H, Jia J, Huo Y, Willer CJ, Chen YE, Tang CS, Tse HF, Lam KSL, Gao W, Xu M, Yu H, Sham PC, Zhang Y, Ganesh SK.
PMID: 33693786
Hum Mol Genet. 2021 May 28;30(9):836-842. doi: 10.1093/hmg/ddab062.

Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European ancestry. We sought to conduct unbiased genetic discovery for coding variants that influence hematological traits in a Han Chinese population....

Cite
Sun P, Zhou W, Fu Y, et al. An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Hum Mol Genet. 2021;30(9):836-842doi: 10.1093/hmg/ddab062.
Sun, P., Zhou, W., Fu, Y., Cheung, C. Y. Y., Dong, Y., Yang, M. L., Zhang, H., Jia, J., Huo, Y., Willer, C. J., Chen, Y. E., Tang, C. S., Tse, H. F., Lam, K. S. L., Gao, W., Xu, M., Yu, H., Sham, P. C., Zhang, Y., & Ganesh, S. K. (2021). An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Human molecular genetics, 30(9), 836-842. https://doi.org/10.1093/hmg/ddab062
Sun, Pengfei, et al. "An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population." Human molecular genetics vol. 30,9 (2021): 836-842. doi: https://doi.org/10.1093/hmg/ddab062
Sun P, Zhou W, Fu Y, Cheung CYY, Dong Y, Yang ML, Zhang H, Jia J, Huo Y, Willer CJ, Chen YE, Tang CS, Tse HF, Lam KSL, Gao W, Xu M, Yu H, Sham PC, Zhang Y, Ganesh SK. An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population. Hum Mol Genet. 2021 May 28;30(9):836-842. doi: 10.1093/hmg/ddab062. PMID: 33693786; PMCID: PMC8161516.
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SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism.

Viruses

Kumar N, Zuo Y, Yalavarthi S, Hunker KL, Knight JS, Kanthi Y, Obi AT, Ganesh SK.
PMID: 34835015
Viruses. 2021 Nov 03;13(11). doi: 10.3390/v13112209.

Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The vascular effects of androgen signaling and inflammatory cytokines in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated endothelial injury...

Cite
Kumar N, Zuo Y, Yalavarthi S, et al. SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism. Viruses. 2021;13(11)doi: 10.3390/v13112209.
Kumar, N., Zuo, Y., Yalavarthi, S., Hunker, K. L., Knight, J. S., Kanthi, Y., Obi, A. T., & Ganesh, S. K. (2021). SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism. Viruses, 13(11), . https://doi.org/10.3390/v13112209
Kumar, Nitin, et al. "SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism." Viruses vol. 13,11 (2021). doi: https://doi.org/10.3390/v13112209
Kumar N, Zuo Y, Yalavarthi S, Hunker KL, Knight JS, Kanthi Y, Obi AT, Ganesh SK. SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism. Viruses. 2021 Nov 03;13(11). doi: 10.3390/v13112209. PMID: 34835015; PMCID: PMC8617813.
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Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease.

Hypertension (Dallas, Tex. : 1979)

Sun P, Kumar N, Tin A, Zhao J, Brown MR, Lin Z, Yang ML, Zheng Q, Jia J, Bielak LF, Yu B, Boerwinkle E, Hunker KL, Coresh J, Chen YE, Huo Y, Kardia SLR, Khoriaty R, Zhou X, Morrison AC, Zhang Y, Ganesh SK.
PMID: 34488438
Hypertension. 2021 Nov;78(5):1555-1566. doi: 10.1161/HYPERTENSIONAHA.121.17597. Epub 2021 Sep 07.

[Figure: see text].

Cite
Sun P, Kumar N, Tin A, et al. Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension. 2021;78(5):1555-1566doi: 10.1161/HYPERTENSIONAHA.121.17597.
Sun, P., Kumar, N., Tin, A., Zhao, J., Brown, M. R., Lin, Z., Yang, M. L., Zheng, Q., Jia, J., Bielak, L. F., Yu, B., Boerwinkle, E., Hunker, K. L., Coresh, J., Chen, Y. E., Huo, Y., Kardia, S. L. R., Khoriaty, R., Zhou, X., Morrison, A. C., Zhang, Y., & Ganesh, S. K. (2021). Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension (Dallas, Tex. : 1979), 78(5), 1555-1566. https://doi.org/10.1161/HYPERTENSIONAHA.121.17597
Sun, Pengfei, et al. "Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease." Hypertension (Dallas, Tex. : 1979) vol. 78,5 (2021): 1555-1566. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17597
Sun P, Kumar N, Tin A, Zhao J, Brown MR, Lin Z, Yang ML, Zheng Q, Jia J, Bielak LF, Yu B, Boerwinkle E, Hunker KL, Coresh J, Chen YE, Huo Y, Kardia SLR, Khoriaty R, Zhou X, Morrison AC, Zhang Y, Ganesh SK. Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease. Hypertension. 2021 Nov;78(5):1555-1566. doi: 10.1161/HYPERTENSIONAHA.121.17597. Epub 2021 Sep 07. PMID: 34488438; PMCID: PMC8516734.
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Showing 1 to 6 of 6 entries