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Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy.

ACS pharmacology & translational science

Li J, Liu S, Shi J, Wang X, Xue Y, Zhu HJ.
PMID: 33855276
ACS Pharmacol Transl Sci. 2021 Apr 01;4(2):870-887. doi: 10.1021/acsptsci.1c00016. eCollection 2021 Apr 09.

Nucleoside and nucleotide analogs are an essential class of antivirals for COVID-19 treatment. Several nucleoside/nucleotide analogs have shown promising effects against SARS-CoV-2

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Li J, Liu S, Shi J, et al. Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy. ACS Pharmacol Transl Sci. 2021;4(2):870-887doi: 10.1021/acsptsci.1c00016.
Li, J., Liu, S., Shi, J., Wang, X., Xue, Y., & Zhu, H. J. (2021). Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy. ACS pharmacology & translational science, 4(2), 870-887. https://doi.org/10.1021/acsptsci.1c00016
Li, Jiapeng, et al. "Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy." ACS pharmacology & translational science vol. 4,2 (2021): 870-887. doi: https://doi.org/10.1021/acsptsci.1c00016
Li J, Liu S, Shi J, Wang X, Xue Y, Zhu HJ. Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy. ACS Pharmacol Transl Sci. 2021 Apr 01;4(2):870-887. doi: 10.1021/acsptsci.1c00016. eCollection 2021 Apr 09. PMID: 33855276; PMCID: PMC8033752.
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Highly Variable Expression of .

Journal of molecular and genetic medicine : an international journal of biomedical research

Sun JW, Collins JM, Ling D, Wang D.
PMID: 32457812
J Mol Genet Med. 2019;13(3). Epub 2019 Sep 30.

Estrogen receptor alpha (

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Sun JW, Collins JM, Ling D, et al. Highly Variable Expression of . J Mol Genet Med. 2019;13(3)
Sun, J. W., Collins, J. M., Ling, D., & Wang, D. (2019). Highly Variable Expression of . Journal of molecular and genetic medicine : an international journal of biomedical research, 13(3), .
Sun, J W, et al. "Highly Variable Expression of ." Journal of molecular and genetic medicine : an international journal of biomedical research vol. 13,3 (2019).
Sun JW, Collins JM, Ling D, Wang D. Highly Variable Expression of . J Mol Genet Med. 2019;13(3). Epub 2019 Sep 30. PMID: 32457812; PMCID: PMC7249510.
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Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.

Drug metabolism and disposition: the biological fate of chemicals

Collins JM, Lu R, Wang X, Zhu HJ, Wang D.
PMID: 34697082
Drug Metab Dispos. 2022 Jan;50(1):43-48. doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25.

Carboxylesterase 1 (

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Collins JM, Lu R, Wang X, et al. Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug Metab Dispos. 2021;50(1):43-48doi: 10.1124/dmd.121.000649.
Collins, J. M., Lu, R., Wang, X., Zhu, H. J., & Wang, D. (2022). Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug metabolism and disposition: the biological fate of chemicals, 50(1), 43-48. https://doi.org/10.1124/dmd.121.000649
Collins, Joseph M, et al. "Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms." Drug metabolism and disposition: the biological fate of chemicals vol. 50,1 (2022): 43-48. doi: https://doi.org/10.1124/dmd.121.000649
Collins JM, Lu R, Wang X, Zhu HJ, Wang D. Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug Metab Dispos. 2022 Jan;50(1):43-48. doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25. PMID: 34697082.
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Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.

Clinical and translational science

Wang X, Her L, Xiao J, Shi J, Wu AH, Bleske BE, Zhu HJ.
PMID: 33660934
Clin Transl Sci. 2021 Jul;14(4):1380-1389. doi: 10.1111/cts.12989. Epub 2021 Mar 04.

Trandolapril, an angiotensin-converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect. A previous in vitro study demonstrated that the CES1 genetic variant G143E (rs71647871) abolished CES1-mediated trandolapril...

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Wang X, Her L, Xiao J, et al. Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Transl Sci. 2021;14(4):1380-1389doi: 10.1111/cts.12989.
Wang, X., Her, L., Xiao, J., Shi, J., Wu, A. H., Bleske, B. E., & Zhu, H. J. (2021). Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. Clinical and translational science, 14(4), 1380-1389. https://doi.org/10.1111/cts.12989
Wang, Xinwen, et al. "Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers." Clinical and translational science vol. 14,4 (2021): 1380-1389. doi: https://doi.org/10.1111/cts.12989
Wang X, Her L, Xiao J, Shi J, Wu AH, Bleske BE, Zhu HJ. Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Transl Sci. 2021 Jul;14(4):1380-1389. doi: 10.1111/cts.12989. Epub 2021 Mar 04. PMID: 33660934; PMCID: PMC8301577.
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Genome-wide pQTL analysis of protein expression regulatory networks in the human liver.

BMC biology

He B, Shi J, Wang X, Jiang H, Zhu HJ.
PMID: 32778093
BMC Biol. 2020 Aug 10;18(1):97. doi: 10.1186/s12915-020-00830-3.

BACKGROUND: Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein...

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He B, Shi J, Wang X, et al. Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. BMC Biol. 2020;18(1):97doi: 10.1186/s12915-020-00830-3.
He, B., Shi, J., Wang, X., Jiang, H., & Zhu, H. J. (2020). Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. BMC biology, 18(1), 97. https://doi.org/10.1186/s12915-020-00830-3
He, Bing, et al. "Genome-wide pQTL analysis of protein expression regulatory networks in the human liver." BMC biology vol. 18,1 (2020): 97. doi: https://doi.org/10.1186/s12915-020-00830-3
He B, Shi J, Wang X, Jiang H, Zhu HJ. Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. BMC Biol. 2020 Aug 10;18(1):97. doi: 10.1186/s12915-020-00830-3. PMID: 32778093; PMCID: PMC7418398.
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Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.

Drug metabolism and disposition: the biological fate of chemicals

Collins JM, Lu R, Wang X, Zhu HJ, Wang D.
PMID: 34697082
Drug Metab Dispos. 2022 Jan;50(1):43-48. doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25.

Carboxylesterase 1 (

Cite
Collins JM, Lu R, Wang X, et al. Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug Metab Dispos. 2021;50(1):43-48doi: 10.1124/dmd.121.000649.
Collins, J. M., Lu, R., Wang, X., Zhu, H. J., & Wang, D. (2022). Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug metabolism and disposition: the biological fate of chemicals, 50(1), 43-48. https://doi.org/10.1124/dmd.121.000649
Collins, Joseph M, et al. "Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms." Drug metabolism and disposition: the biological fate of chemicals vol. 50,1 (2022): 43-48. doi: https://doi.org/10.1124/dmd.121.000649
Collins JM, Lu R, Wang X, Zhu HJ, Wang D. Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. Drug Metab Dispos. 2022 Jan;50(1):43-48. doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25. PMID: 34697082.
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Transcriptional regulation of carboxylesterase 1 (.

Drug metabolism and disposition: the biological fate of chemicals

Collins JM, Lu R, Wang X, Zhu HJ, Wang D.
PMID: 34697082
Drug Metab Dispos. 2021 Oct 25; doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25.

Carboxylesterase 1 (

Cite
Collins JM, Lu R, Wang X, et al. Transcriptional regulation of carboxylesterase 1 (. Drug Metab Dispos. 2021;doi: 10.1124/dmd.121.000649.
Collins, J. M., Lu, R., Wang, X., Zhu, H. J., & Wang, D. (2021). Transcriptional regulation of carboxylesterase 1 (. Drug metabolism and disposition: the biological fate of chemicals, . https://doi.org/10.1124/dmd.121.000649
Collins, Joseph M, et al. "Transcriptional regulation of carboxylesterase 1 (." Drug metabolism and disposition: the biological fate of chemicals vol. (2021). doi: https://doi.org/10.1124/dmd.121.000649
Collins JM, Lu R, Wang X, Zhu HJ, Wang D. Transcriptional regulation of carboxylesterase 1 (. Drug Metab Dispos. 2021 Oct 25; doi: 10.1124/dmd.121.000649. Epub 2021 Oct 25. PMID: 34697082.
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Showing 1 to 7 of 7 entries