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Showing 1 to 11 of 11 entries
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Finding Expandable Induced Cardiovascular Progenitor Cells.

Circulation research

Chen IY, Wu JC.
PMID: 27340267
Circ Res. 2016 Jun 24;119(1):16-20. doi: 10.1161/CIRCRESAHA.116.308679.

No abstract available.

The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes.

Seminars in cell & developmental biology

Jahng JWS, Zhang M, Wu JC.
PMID: 34074592
Semin Cell Dev Biol. 2021 May 29; doi: 10.1016/j.semcdb.2021.05.018. Epub 2021 May 29.

The advent of induced pluripotent stem cells (iPSCs) and identification of transcription factors for cardiac reprogramming have raised hope to cure heart disease, the leading cause of death in the world. Our knowledge in heart development and molecular barriers...

Race and Genetics in Congenital Heart Disease: Application of iPSCs, Omics, and Machine Learning Technologies.

Frontiers in cardiovascular medicine

Mullen M, Zhang A, Lui GK, Romfh AW, Rhee JW, Wu JC.
PMID: 33681306
Front Cardiovasc Med. 2021 Feb 17;8:635280. doi: 10.3389/fcvm.2021.635280. eCollection 2021.

Congenital heart disease (CHD) is a multifaceted cardiovascular anomaly that occurs when there are structural abnormalities in the heart before birth. Although various risk factors are known to influence the development of this disease, a full comprehension of the...

Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying TNNI3 mutations.

Stem cell research

Zhao SR, Shen M, Lee C, Zha Y, Guevara JV, Wheeler MT, Wu JC.
PMID: 34798544
Stem Cell Res. 2021 Nov 12;57:102597. doi: 10.1016/j.scr.2021.102597. Epub 2021 Nov 12.

Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with a prevalence of about 0.2%. HCM is typically caused by mutations in genes encoding sarcomere or sarcomere-associated proteins. Here, we characterized induced pluripotent stem cell (iPSC) lines generated from...

Generation of three induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying TNNI3 mutations.

Stem cell research

Zhao SR, Shen M, Lee C, Zha Y, Guevara JV, Wheeler MT, Wu JC.
PMID: 34798544
Stem Cell Res. 2021 Nov 12;57:102597. doi: 10.1016/j.scr.2021.102597. Epub 2021 Nov 12.

Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with a prevalence of about 0.2%. HCM is typically caused by mutations in genes encoding sarcomere or sarcomere-associated proteins. Here, we characterized induced pluripotent stem cell (iPSC) lines generated from...

The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes.

Seminars in cell & developmental biology

Jahng JWS, Zhang M, Wu JC.
PMID: 34074592
Semin Cell Dev Biol. 2021 May 29; doi: 10.1016/j.semcdb.2021.05.018. Epub 2021 May 29.

The advent of induced pluripotent stem cells (iPSCs) and identification of transcription factors for cardiac reprogramming have raised hope to cure heart disease, the leading cause of death in the world. Our knowledge in heart development and molecular barriers...

Systems-Wide Approaches in Induced Pluripotent Stem Cell Models.

Annual review of pathology

Lau E, Paik DT, Wu JC.
PMID: 30379619
Annu Rev Pathol. 2019 Jan 24;14:395-419. doi: 10.1146/annurev-pathmechdis-012418-013046. Epub 2018 Oct 31.

Human induced pluripotent stem cells (iPSCs) provide a renewable supply of patient-specific and tissue-specific cells for cellular and molecular studies of disease mechanisms. Combined with advances in various omics technologies, iPSC models can be used to profile the expression...

Effects of Cryopreservation on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles.

Stem cell reports

Zhang JZ, Belbachir N, Zhang T, Liu Y, Shrestha R, Wu JC.
PMID: 33338435
Stem Cell Reports. 2021 Jan 12;16(1):168-181. doi: 10.1016/j.stemcr.2020.11.010. Epub 2020 Dec 17.

Burgeoning applications of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in disease modeling, regenerative medicine, and drug screening have broadened the usage of hiPSC-CMs and entailed their long-term storage. Cryopreservation is the most common approach to store hiPSC-CMs. However,...

The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes.

Seminars in cell & developmental biology

Jahng JWS, Zhang M, Wu JC.
PMID: 34074592
Semin Cell Dev Biol. 2021 May 29; doi: 10.1016/j.semcdb.2021.05.018. Epub 2021 May 29.

The advent of induced pluripotent stem cells (iPSCs) and identification of transcription factors for cardiac reprogramming have raised hope to cure heart disease, the leading cause of death in the world. Our knowledge in heart development and molecular barriers...

The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes.

Seminars in cell & developmental biology

Jahng JWS, Zhang M, Wu JC.
PMID: 34074592
Semin Cell Dev Biol. 2021 May 29; doi: 10.1016/j.semcdb.2021.05.018. Epub 2021 May 29.

The advent of induced pluripotent stem cells (iPSCs) and identification of transcription factors for cardiac reprogramming have raised hope to cure heart disease, the leading cause of death in the world. Our knowledge in heart development and molecular barriers...

Reconstructing the heart using iPSCs: Engineering strategies and applications.

Journal of molecular and cellular cardiology

Cho S, Lee C, Skylar-Scott MA, Heilshorn SC, Wu JC.
PMID: 33895197
J Mol Cell Cardiol. 2021 Aug;157:56-65. doi: 10.1016/j.yjmcc.2021.04.006. Epub 2021 Apr 22.

Induced pluripotent stem cells (iPSCs) have emerged as a key component of cardiac tissue engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and developmental processes in human 3D tissue models assembled from isogenic cells. Since the very first...

Showing 1 to 11 of 11 entries