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Showing 1 to 5 of 5 entries
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Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling.

Vessel plus

Dong Y, Wu H, Dong J, Song K, Rahman HA, Towner R, Chen H.
PMID: 29905336
Vessel Plus. 2017;1:3-11. doi: 10.20517/2574-1209.2016.01. Epub 2017 Mar 31.

Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysregulating vascular endothelial growth factor receptor-2 (VEGFR2)...

Insights from Genetic Model Systems of Retinal Degeneration: Role of Epsins in Retinal Angiogenesis and VEGFR2 Signaling.

Journal of nature and science

Dong Y, Cai X, Wu Y, Liu Y, Deng L, Chen H.
PMID: 28191500
J Nat Sci. 2017 Jan;3(1).

The retina is a light sensitive tissue that contains specialized photoreceptor cells called rods and cones which process visual signals. These signals are relayed to the brain through interneurons and the fibers of the optic nerve. The retina is...

Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer Progression.

Journal of cancer research updates

Tessneer KL, Cai X, Pasula S, Dong Y, Liu X, Chang B, McManus J, Hahn S, Yu L, Chen H.
PMID: 24501612
J Can Res Updates. 2013 Jul 01;2(3):144-150. doi: 10.6000/1929-2279.2013.02.03.2.

Tumor angiogenesis, tumor cell proliferation, and tumor cell migration result from an accumulation of oncogenic mutations that alter protein expression and the regulation of various signaling cascades. Epsins, a small family of clathrin-mediated endocytic adaptor proteins, are reportedly upregulated...

Cardiotoxicity of Anticancer Therapeutics.

Frontiers in cardiovascular medicine

Dong J, Chen H.
PMID: 29473044
Front Cardiovasc Med. 2018 Feb 07;5:9. doi: 10.3389/fcvm.2018.00009. eCollection 2018.

As cancer therapeutics continues to improve and progress, the adverse side effects associated with anticancer treatments have also attracted more attention and have become extensively explored. Consequently, the importance of posttreatment follow-ups is becoming increasingly relevant to the discussion....

Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance.

Frontiers in cardiovascular medicine

Li M, Qian M, Xu J.
PMID: 28848738
Front Cardiovasc Med. 2017 Aug 09;4:51. doi: 10.3389/fcvm.2017.00051. eCollection 2017.

Obesity is a worldwide epidemic that predisposes individuals to metabolic complications, such as type 2 diabetes mellitus and non-alcoholic fatty liver disease, all of which are related to an imbalance between food intake and energy expenditure. Identification of the...

Showing 1 to 5 of 5 entries