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Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure.

Frontiers in physiology

Li J, Agvanian S, Zhou K, Shaw RM, Hong T.
PMID: 32670093
Front Physiol. 2020 Jun 24;11:708. doi: 10.3389/fphys.2020.00708. eCollection 2020.

No abstract available.

In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function.

JACC. Basic to translational science

Liu Y, Zhou K, Li J, Agvanian S, Caldaruse AM, Shaw S, Hitzeman TC, Shaw RM, Hong T.
PMID: 32613144
JACC Basic Transl Sci. 2020 May 13;5(6):561-578. doi: 10.1016/j.jacbts.2020.03.006. eCollection 2020 Jun.

Heart failure is an important, and growing, cause of morbidity and mortality. Half of patients with heart failure have preserved ejection fraction, for whom therapeutic options are limited. Here we report that cardiac bridging integrator 1 gene therapy to...

cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events.

Frontiers in physiology

Hitzeman TC, Xie Y, Zadikany RH, Nikolova AP, Baum R, Caldaruse AM, Agvanian S, Melmed GY, McGovern DPB, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw RM.
PMID: 32670075
Front Physiol. 2020 May 25;11:503. doi: 10.3389/fphys.2020.00503. eCollection 2020.

BACKGROUND: Cardiac Bridging Integrator 1 (cBIN1) is a membrane deformation protein that generates calcium microdomains at cardiomyocyte t-tubules, whose transcription is reduced in heart failure, and is released into blood. cBIN1 score (CS), an inverse index of plasma cBIN1,...

Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport.

Frontiers in physiology

Fu Y, Zhang SS, Xiao S, Basheer WA, Baum R, Epifantseva I, Hong T, Shaw RM.
PMID: 29163229
Front Physiol. 2017 Nov 07;8:905. doi: 10.3389/fphys.2017.00905. eCollection 2017.

Connexin 43 (Cx43, encoded by

Showing 1 to 4 of 4 entries