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Showing 1 to 7 of 7 entries
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Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes.

BMC proceedings

Peralta JM, Almasy L.
PMID: 18466503
BMC Proc. 2007;1:S158. doi: 10.1186/1753-6561-1-s1-s158. Epub 2007 Dec 18.

We compared results from linkage analyses of different phenotype measurements from the same gene expression traits and found that the strongest signals were detected by all expression measures that we considered. On average, that meant that the same quantitative...

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.

Frontiers in neuroscience

Kochunov P, Glahn DC, Nichols TE, Winkler AM, Hong EL, Holcomb HH, Stein JL, Thompson PM, Curran JE, Carless MA, Olvera RL, Johnson MP, Cole SA, Kochunov V, Kent J, Blangero J.
PMID: 22028680
Front Neurosci. 2011 Oct 19;5:120. doi: 10.3389/fnins.2011.00120. eCollection 2011.

OBJECTIVES: The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated...

P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

Frontiers in genetics

Kochunov P, Glahn DC, Hong LE, Lancaster J, Curran JE, Johnson MP, Winkler AM, Holcomb HH, Kent JW, Mitchell B, Kochunov V, Olvera RL, Cole SA, Dyer TD, Moses EK, Goring H, Almasy L, Duggirala R, Blangero J.
PMID: 22558002
Front Genet. 2012 May 01;3:65. doi: 10.3389/fgene.2012.00065. eCollection 2012.

BACKGROUND AND PURPOSE: We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene...

Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs.

Human brain mapping

Sønderby IE, Ching CRK, Thomopoulos SI, van der Meer D, Sun D, Villalon-Reina JE, Agartz I, Amunts K, Arango C, Armstrong NJ, Ayesa-Arriola R, Bakker G, Bassett AS, Boomsma DI, Bülow R, Butcher NJ, Calhoun VD, Caspers S, Chow EWC, Cichon S, Ciufolini S, Craig MC, Crespo-Facorro B, Cunningham AC, Dale AM, Dazzan P, de Zubicaray GI, Djurovic S, Doherty JL, Donohoe G, Draganski B, Durdle CA, Ehrlich S, Emanuel BS, Espeseth T, Fisher SE, Ge T, Glahn DC, Grabe HJ, Gur RE, Gutman BA, Haavik J, Håberg AK, Hansen LA, Hashimoto R, Hibar DP, Holmes AJ, Hottenga JJ, Hulshoff Pol HE, Jalbrzikowski M, Knowles EEM, Kushan L, Linden DEJ, Liu J, Lundervold AJ, Martin-Brevet S, Martínez K, Mather KA, Mathias SR, McDonald-McGinn DM, McRae AF, Medland SE, Moberget T, Modenato C, Monereo Sánchez J, Moreau CA, Mühleisen TW, Paus T, Pausova Z, Prieto C, Ragothaman A, Reinbold CS, Reis Marques T, Repetto GM, Reymond A, Roalf DR, Rodriguez-Herreros B, Rucker JJ, Sachdev PS, Schmitt JE, Schofield PR, Silva AI, Stefansson H, Stein DJ, Tamnes CK, Tordesillas-Gutiérrez D, Ulfarsson MO, Vajdi A, van 't Ent D, van den Bree MBM, Vassos E, Vázquez-Bourgon J, Vila-Rodriguez F, Walters GB, Wen W, Westlye LT, Wittfeld K, Zackai EH, Stefánsson K, Jacquemont S, Thompson PM, Bearden CE, Andreassen OA.
PMID: 33615640
Hum Brain Mapp. 2022 Jan;43(1):300-328. doi: 10.1002/hbm.25354. Epub 2021 Feb 21.

The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral...

Genome-Wide Analyses of Working-Memory Ability: A Review.

Current behavioral neuroscience reports

Knowles EE, Mathias SR, McKay DR, Sprooten E, Blangero J, Almasy L, Glahn DC.
PMID: 25729637
Curr Behav Neurosci Rep. 2014 Dec;1(4):224-233. doi: 10.1007/s40473-014-0028-8.

Working memory, a theoretical construct from the field of cognitive psychology, is crucial to everyday life. It refers to the ability to temporarily store and manipulate task-relevant information. The identification of genes for working memory might shed light on...

Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos.

Frontiers in genetics

Voruganti VS, Higgins PB, Ebbesson SO, Kennish J, Göring HH, Haack K, Laston S, Drigalenko E, Wenger CR, Harris WS, Fabsitz RR, Devereux RB, Maccluer JW, Curran JE, Carless MA, Johnson MP, Moses EK, Blangero J, Umans JG, Howard BV, Cole SA, Comuzzie AG.
PMID: 22701466
Front Genet. 2012 Jun 11;3:86. doi: 10.3389/fgene.2012.00086. eCollection 2012.

The delta-5 and delta-6 desaturases (D5D and D6D), encoded by fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes, respectively, are rate-limiting enzymes in the metabolism of ω-3 and ω-6 fatty acids. The objective of this study was to...

Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades.

Frontiers in aging neuroscience

Li K, Laird AR, Price LR, McKay DR, Blangero J, Glahn DC, Fox PT.
PMID: 27378909
Front Aging Neurosci. 2016 Jun 14;8:137. doi: 10.3389/fnagi.2016.00137. eCollection 2016.

The default mode network (DMN) is a set of regions that is tonically engaged during the resting state and exhibits task-related deactivation that is readily reproducible across a wide range of paradigms and modalities. The DMN has been implicated...

Showing 1 to 7 of 7 entries