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Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder.

Frontiers in genetics

Judy JT, Seifuddin F, Pirooznia M, Mahon PB, Jancic D, Goes FS, Schulze T, Cichon S, Noethen M, Rietschel M, Depaulo JR, Potash JB, Zandi PP.
PMID: 23730306
Front Genet. 2013 May 17;4:87. doi: 10.3389/fgene.2013.00087. eCollection 2013.

Genome-wide association studies (GWAS) have implicated ANK3 as a susceptibility gene for bipolar disorder (BP). We examined whether epistasis with ANK3 may contribute to the "missing heritability" in BP. We first identified via the STRING database 14 genes encoding...

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