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Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy.

Genome research

Radke DW, Sul JH, Balick DJ, Akle S, Green RC, Sunyaev SR.
PMID: 33963077
Genome Res. 2021 Jun;31(6):935-946. doi: 10.1101/gr.275263.121. Epub 2021 May 07.

Genomic deletions provide a powerful loss-of-function model in noncoding regions to assess the role of purifying selection on genetic variation. Regulatory element function is characterized by nonuniform tissue and cell type activity, necessarily linking the study of fitness consequences...

Cite
Radke DW, Sul JH, Balick DJ, et al. Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy. Genome Res. 2021;31(6):935-946doi: 10.1101/gr.275263.121.
Radke, D. W., Sul, J. H., Balick, D. J., Akle, S., Green, R. C., & Sunyaev, S. R. (2021). Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy. Genome research, 31(6), 935-946. https://doi.org/10.1101/gr.275263.121
Radke, David W, et al. "Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy." Genome research vol. 31,6 (2021): 935-946. doi: https://doi.org/10.1101/gr.275263.121
Radke DW, Sul JH, Balick DJ, Akle S, Green RC, Sunyaev SR. Purifying selection on noncoding deletions of human regulatory loci detected using their cellular pleiotropy. Genome Res. 2021 Jun;31(6):935-946. doi: 10.1101/gr.275263.121. Epub 2021 May 07. PMID: 33963077; PMCID: PMC8168579.
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Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
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Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.

Nature neuroscience

Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki M, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman C, Neale BM.
PMID: 27694993
Nat Neurosci. 2016 Dec;19(12):1563-1565. doi: 10.1038/nn.4404. Epub 2016 Oct 03.

Disruptive, damaging ultra-rare variants in highly constrained genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE). This effect was stronger among highly...

Cite
Ganna A, Genovese G, Howrigan DP, et al. Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nat Neurosci. 2016;19(12):1563-1565doi: 10.1038/nn.4404.
Ganna, A., Genovese, G., Howrigan, D. P., Byrnes, A., Kurki, M., Zekavat, S. M., Whelan, C. W., Kals, M., Nivard, M. G., Bloemendal, A., Bloom, J. M., Goldstein, J. I., Poterba, T., Seed, C., Handsaker, R. E., Natarajan, P., Mägi, R., Gage, D., Robinson, E. B., Metspalu, A., Salomaa, V., Suvisaari, J., Purcell, S. M., Sklar, P., Kathiresan, S., Daly, M. J., McCarroll, S. A., Sullivan, P. F., Palotie, A., Esko, T., Hultman, C., & Neale, B. M. (2016). Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nature neuroscience, 19(12), 1563-1565. https://doi.org/10.1038/nn.4404
Ganna, Andrea, et al. "Ultra-rare disruptive and damaging mutations influence educational attainment in the general population." Nature neuroscience vol. 19,12 (2016): 1563-1565. doi: https://doi.org/10.1038/nn.4404
Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki M, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman C, Neale BM. Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nat Neurosci. 2016 Dec;19(12):1563-1565. doi: 10.1038/nn.4404. Epub 2016 Oct 03. PMID: 27694993; PMCID: PMC5127781.
Copy Download .nbib Format: NLM
Resource profile and user guide of the Polygenic Index Repository.

Nature human behaviour

Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A.
PMID: 34140656
Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17.

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the...

Cite
Becker J, Burik CAP, Goldman G, et al. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021;5(12):1744-1758doi: 10.1038/s41562-021-01119-3.
Becker, J., Burik, C. A. P., Goldman, G., Wang, N., Jayashankar, H., Bennett, M., Belsky, D. W., Karlsson Linnér, R., Ahlskog, R., Kleinman, A., Hinds, D. A., Caspi, A., Corcoran, D. L., Moffitt, T. E., Poulton, R., Sugden, K., Williams, B. S., Harris, K. M., Steptoe, A., Ajnakina, O., Milani, L., Esko, T., Iacono, W. G., McGue, M., Magnusson, P. K. E., Mallard, T. T., Harden, K. P., Tucker-Drob, E. M., Herd, P., Freese, J., Young, A., Beauchamp, J. P., Koellinger, P. D., Oskarsson, S., Johannesson, M., Visscher, P. M., Meyer, M. N., Laibson, D., Cesarini, D., Benjamin, D. J., Turley, P., & Okbay, A. (2021). Resource profile and user guide of the Polygenic Index Repository. Nature human behaviour, 5(12), 1744-1758. https://doi.org/10.1038/s41562-021-01119-3
Becker, Joel, et al. "Resource profile and user guide of the Polygenic Index Repository." Nature human behaviour vol. 5,12 (2021): 1744-1758. doi: https://doi.org/10.1038/s41562-021-01119-3
Becker J, Burik CAP, Goldman G, Wang N, Jayashankar H, Bennett M, Belsky DW, Karlsson Linnér R, Ahlskog R, Kleinman A, Hinds DA, Caspi A, Corcoran DL, Moffitt TE, Poulton R, Sugden K, Williams BS, Harris KM, Steptoe A, Ajnakina O, Milani L, Esko T, Iacono WG, McGue M, Magnusson PKE, Mallard TT, Harden KP, Tucker-Drob EM, Herd P, Freese J, Young A, Beauchamp JP, Koellinger PD, Oskarsson S, Johannesson M, Visscher PM, Meyer MN, Laibson D, Cesarini D, Benjamin DJ, Turley P, Okbay A. Resource profile and user guide of the Polygenic Index Repository. Nat Hum Behav. 2021 Dec;5(12):1744-1758. doi: 10.1038/s41562-021-01119-3. Epub 2021 Jun 17. PMID: 34140656; PMCID: PMC8678380.
Copy Download .nbib Format: NLM
Showing 1 to 5 of 5 entries