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19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium.

Neurology. Genetics

[No authors listed]
PMID: 28428977
Neurol Genet. 2017 Mar 30;3(1):S2-S11. doi: 10.1212/NXG.0000000000000100. eCollection 2017 Mar.

No abstract available.

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19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium. Neurol Genet. 2017;3(1):S2-S11doi: 10.1212/NXG.0000000000000100.
(2017). 19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium. Neurology. Genetics, 3(1), S2-S11. https://doi.org/10.1212/NXG.0000000000000100
"19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium." Neurology. Genetics vol. 3,1 (2017): S2-S11. doi: https://doi.org/10.1212/NXG.0000000000000100
19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium. Neurol Genet. 2017 Mar 30;3(1):S2-S11. doi: 10.1212/NXG.0000000000000100. eCollection 2017 Mar. PMID: 28428977; PMCID: PMC5390739.
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White matter changes, creatinine, age, and ankle-arm index predicted incident MRI-defined infarctions in older adults.

ACP journal club

DeCarli C.
PMID: 12841727
ACP J Club. 2003 Jul-Aug;139(1):23.

No abstract available.

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DeCarli C. White matter changes, creatinine, age, and ankle-arm index predicted incident MRI-defined infarctions in older adults. ACP J Club. 2003;139(1):23
DeCarli, C. (2003). White matter changes, creatinine, age, and ankle-arm index predicted incident MRI-defined infarctions in older adults. ACP journal club, 139(1), 23.
DeCarli, Charles. "White matter changes, creatinine, age, and ankle-arm index predicted incident MRI-defined infarctions in older adults." ACP journal club vol. 139,1 (2003): 23.
DeCarli C. White matter changes, creatinine, age, and ankle-arm index predicted incident MRI-defined infarctions in older adults. ACP J Club. 2003 Jul-Aug;139(1):23. PMID: 12841727.
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Epidemiology of Stroke: Legacy of the Framingham Heart Study.

Global heart

Romero JR, Wolf PA.
PMID: 23527318
Glob Heart. 2013 Mar 01;8(1):67-75. doi: 10.1016/j.gheart.2012.12.007. Epub 2013 Mar 15.

In the present historical review, we highlight several articles outlining contributions of the Framingham Heart Study over the span of nearly seven decades to our understanding of the epidemiology of blood pressure (BP), atrial fibrillation and genetic factors as...

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Romero JR, Wolf PA. Epidemiology of Stroke: Legacy of the Framingham Heart Study. Glob Heart. 2013;8(1):67-75doi: 10.1016/j.gheart.2012.12.007.
Romero, J. R., & Wolf, P. A. (2013). Epidemiology of Stroke: Legacy of the Framingham Heart Study. Global heart, 8(1), 67-75. https://doi.org/10.1016/j.gheart.2012.12.007
Romero, Jose R, and Wolf, Philip A. "Epidemiology of Stroke: Legacy of the Framingham Heart Study." Global heart vol. 8,1 (2013): 67-75. doi: https://doi.org/10.1016/j.gheart.2012.12.007
Romero JR, Wolf PA. Epidemiology of Stroke: Legacy of the Framingham Heart Study. Glob Heart. 2013 Mar 01;8(1):67-75. doi: 10.1016/j.gheart.2012.12.007. Epub 2013 Mar 15. PMID: 23527318; PMCID: PMC3601756.
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Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study.

American journal of epidemiology

Li J, Joshi P, Ang TFA, Liu C, Auerbach S, Devine S, Au R.
PMID: 33831181
Am J Epidemiol. 2021 Dec 01;190(12):2503-2510. doi: 10.1093/aje/kwab096.

Growing evidence relates body mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3,632 Framingham Offspring participants aged 20 to 60 years at their second health examination (1979-1983)...

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Li J, Joshi P, Ang TFA, et al. Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study. Am J Epidemiol. 2021;190(12):2503-2510doi: 10.1093/aje/kwab096.
Li, J., Joshi, P., Ang, T. F. A., Liu, C., Auerbach, S., Devine, S., & Au, R. (2021). Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study. American journal of epidemiology, 190(12), 2503-2510. https://doi.org/10.1093/aje/kwab096
Li, Jinlei, et al. "Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study." American journal of epidemiology vol. 190,12 (2021): 2503-2510. doi: https://doi.org/10.1093/aje/kwab096
Li J, Joshi P, Ang TFA, Liu C, Auerbach S, Devine S, Au R. Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study. Am J Epidemiol. 2021 Dec 01;190(12):2503-2510. doi: 10.1093/aje/kwab096. PMID: 33831181.
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The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

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Li S, Weinstein G, Zare H, et al. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020;2(2):fcaa176doi: 10.1093/braincomms/fcaa176.
Li, S., Weinstein, G., Zare, H., Teumer, A., Völker, U., Friedrich, N., Knol, M. J., Satizabal, C. L., Petyuk, V. A., Adams, H. H. H., Launer, L. J., Bennett, D. A., De Jager, P. L., Grabe, H. J., Ikram, M. A., Gudnason, V., Yang, Q., & Seshadri, S. (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain communications, 2(2), fcaa176. https://doi.org/10.1093/braincomms/fcaa176
Li, Shuo, et al. "The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages." Brain communications vol. 2,2 (2020): fcaa176. doi: https://doi.org/10.1093/braincomms/fcaa176
Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S. The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages. Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020. PMID: 33345186; PMCID: PMC7734441.
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Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study.

Stroke

Cooper LL, Wang N, Beiser AS, Romero JR, Aparicio HJ, Lioutas VA, Benjamin EJ, Larson MG, Vasan RS, Mitchell GF, Seshadri S, Hamburg NM.
PMID: 34192894
Stroke. 2021 Aug;52(9):2866-2873. doi: 10.1161/STROKEAHA.120.031102. Epub 2021 Jul 01.

[Figure: see text].

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Cooper LL, Wang N, Beiser AS, et al. Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study. Stroke. 2021;52(9):2866-2873doi: 10.1161/STROKEAHA.120.031102.
Cooper, L. L., Wang, N., Beiser, A. S., Romero, J. R., Aparicio, H. J., Lioutas, V. A., Benjamin, E. J., Larson, M. G., Vasan, R. S., Mitchell, G. F., Seshadri, S., & Hamburg, N. M. (2021). Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study. Stroke, 52(9), 2866-2873. https://doi.org/10.1161/STROKEAHA.120.031102
Cooper, Leroy L, et al. "Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study." Stroke vol. 52,9 (2021): 2866-2873. doi: https://doi.org/10.1161/STROKEAHA.120.031102
Cooper LL, Wang N, Beiser AS, Romero JR, Aparicio HJ, Lioutas VA, Benjamin EJ, Larson MG, Vasan RS, Mitchell GF, Seshadri S, Hamburg NM. Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study. Stroke. 2021 Aug;52(9):2866-2873. doi: 10.1161/STROKEAHA.120.031102. Epub 2021 Jul 01. PMID: 34192894; PMCID: PMC8378441.
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Identification of digital voice biomarkers for cognitive health.

Exploration of medicine

Lin H, Karjadi C, Ang TFA, Prajakta J, McManus C, Alhanai TW, Glass J, Au R.
PMID: 33665648
Explor Med. 2020;1:406-417. doi: 10.37349/emed.2020.00028. Epub 2020 Dec 31.

AIM: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are predictive of future dementia.METHODS: Participants...

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Lin H, Karjadi C, Ang TFA, et al. Identification of digital voice biomarkers for cognitive health. Explor Med. 2020;1:406-417doi: 10.37349/emed.2020.00028.
Lin, H., Karjadi, C., Ang, T. F. A., Prajakta, J., McManus, C., Alhanai, T. W., Glass, J., & Au, R. (2020). Identification of digital voice biomarkers for cognitive health. Exploration of medicine, 1406-417. https://doi.org/10.37349/emed.2020.00028
Lin, Honghuang, et al. "Identification of digital voice biomarkers for cognitive health." Exploration of medicine vol. 1 (2020): 406-417. doi: https://doi.org/10.37349/emed.2020.00028
Lin H, Karjadi C, Ang TFA, Prajakta J, McManus C, Alhanai TW, Glass J, Au R. Identification of digital voice biomarkers for cognitive health. Explor Med. 2020;1:406-417. doi: 10.37349/emed.2020.00028. Epub 2020 Dec 31. PMID: 33665648; PMCID: PMC7929495.
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Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S.
PMID: 33874747
Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20.

BACKGROUND AND PURPOSE: The autonomic nervous system has been implicated in stroke and dementia pathophysiology. High resting heart rate and low heart rate variability indicate the effect of autonomic imbalance on the heart. We examined the associations of resting...

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Weinstein G, Davis-Plourde K, Beiser AS, et al. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021;52(6):2068-2076doi: 10.1161/STROKEAHA.120.030601.
Weinstein, G., Davis-Plourde, K., Beiser, A. S., & Seshadri, S. (2021). Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke, 52(6), 2068-2076. https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein, Galit, et al. "Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study." Stroke vol. 52,6 (2021): 2068-2076. doi: https://doi.org/10.1161/STROKEAHA.120.030601
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021 Jun;52(6):2068-2076. doi: 10.1161/STROKEAHA.120.030601. Epub 2021 Apr 20. PMID: 33874747; PMCID: PMC8154675.
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Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.

Alzheimer's & dementia (Amsterdam, Netherlands)

Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA.
PMID: 30976649
Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec.

Advances in technology enable increasing amounts of data collection from individuals for biomedical research. Such technologies, for example, in genetics and medical imaging, have also led to important scientific discoveries about health and disease. The combination of multiple types...

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Adams HHH, Roshchupkin GV, DeCarli C, et al. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019;11:286-290doi: 10.1016/j.dadm.2019.02.003.
Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K., & Ikram, M. A. (2019). Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimer's & dementia (Amsterdam, Netherlands), 11286-290. https://doi.org/10.1016/j.dadm.2019.02.003
Adams, Hieab H H, et al. "Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 286-290. doi: https://doi.org/10.1016/j.dadm.2019.02.003
Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec. PMID: 30976649; PMCID: PMC6441785.
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The Alzheimer's Disease Sequencing Project: Study design and sample selection.

Neurology. Genetics

Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, Wijsman E, Farrer LA, Goate A, Haines JL, Pericak-Vance MA, Boerwinkle E, Mayeux R, Seshadri S, Schellenberg G.
PMID: 29184913
Neurol Genet. 2017 Oct 13;3(5):e194. doi: 10.1212/NXG.0000000000000194. eCollection 2017 Oct.

No abstract available.

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Beecham GW, Bis JC, Martin ER, et al. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet. 2017;3(5):e194doi: 10.1212/NXG.0000000000000194.
Beecham, G. W., Bis, J. C., Martin, E. R., Choi, S. H., DeStefano, A. L., van Duijn, C. M., Fornage, M., Gabriel, S. B., Koboldt, D. C., Larson, D. E., Naj, A. C., Psaty, B. M., Salerno, W., Bush, W. S., Foroud, T. M., Wijsman, E., Farrer, L. A., Goate, A., Haines, J. L., Pericak-Vance, M. A., Boerwinkle, E., Mayeux, R., Seshadri, S., & Schellenberg, G. (2017). The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurology. Genetics, 3(5), e194. https://doi.org/10.1212/NXG.0000000000000194
Beecham, Gary W, et al. "The Alzheimer's Disease Sequencing Project: Study design and sample selection." Neurology. Genetics vol. 3,5 (2017): e194. doi: https://doi.org/10.1212/NXG.0000000000000194
Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, Wijsman E, Farrer LA, Goate A, Haines JL, Pericak-Vance MA, Boerwinkle E, Mayeux R, Seshadri S, Schellenberg G. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet. 2017 Oct 13;3(5):e194. doi: 10.1212/NXG.0000000000000194. eCollection 2017 Oct. PMID: 29184913; PMCID: PMC5646177.
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Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.

Alzheimer's & dementia (New York, N. Y.)

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S.
PMID: 29067329
Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun.

INTRODUCTION: Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link.METHODS: Using the Framingham Study, we examined social relationship measures as predictors of higher serum BDNF level and...

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Salinas J, Beiser A, Himali JJ, et al. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017;3(2):229-237doi: 10.1016/j.trci.2017.03.001.
Salinas, J., Beiser, A., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Weinstein, G., Mateen, F. J., Berkman, L. F., Rosand, J., & Seshadri, S. (2017). Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimer's & dementia (New York, N. Y.), 3(2), 229-237. https://doi.org/10.1016/j.trci.2017.03.001
Salinas, Joel, et al. "Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia." Alzheimer's & dementia (New York, N. Y.) vol. 3,2 (2017): 229-237. doi: https://doi.org/10.1016/j.trci.2017.03.001
Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 10.1016/j.trci.2017.03.001. eCollection 2017 Jun. PMID: 29067329; PMCID: PMC5651441.
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Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities.

Neurology. Genetics

Beecham A, Dong C, Wright CB, Dueker N, Brickman AM, Wang L, DeCarli C, Blanton SH, Rundek T, Mayeux R, Sacco RL.
PMID: 28975155
Neurol Genet. 2017 Sep 25;3(5):e185. doi: 10.1212/NXG.0000000000000185. eCollection 2017 Oct.

OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population.METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922...

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Beecham A, Dong C, Wright CB, et al. Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurol Genet. 2017;3(5):e185doi: 10.1212/NXG.0000000000000185.
Beecham, A., Dong, C., Wright, C. B., Dueker, N., Brickman, A. M., Wang, L., DeCarli, C., Blanton, S. H., Rundek, T., Mayeux, R., & Sacco, R. L. (2017). Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurology. Genetics, 3(5), e185. https://doi.org/10.1212/NXG.0000000000000185
Beecham, Ashley, et al. "Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities." Neurology. Genetics vol. 3,5 (2017): e185. doi: https://doi.org/10.1212/NXG.0000000000000185
Beecham A, Dong C, Wright CB, Dueker N, Brickman AM, Wang L, DeCarli C, Blanton SH, Rundek T, Mayeux R, Sacco RL. Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurol Genet. 2017 Sep 25;3(5):e185. doi: 10.1212/NXG.0000000000000185. eCollection 2017 Oct. PMID: 28975155; PMCID: PMC5619914.
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