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Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.

Parkinson's disease

Chu CT.
PMID: 21603187
Parkinsons Dis. 2011;2011:789431. doi: 10.4061/2011/789431. Epub 2011 Mar 17.

Selective mitochondrial degradation through autophagy (mitophagy) has emerged as an important homeostatic mechanism in a variety of organisms and contexts. Complete clearance of mitochondria can be observed during normal maturation of certain mammalian cell types, and during certain forms...

Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases.

Frontiers in neuroscience

Verma M, Wills Z, Chu CT.
PMID: 30116173
Front Neurosci. 2018 Aug 02;12:523. doi: 10.3389/fnins.2018.00523. eCollection 2018.

Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In addition to excitotoxic neuronal cell death observed following stroke, a growing number of studies implicate excess excitatory neuronal activity in chronic neurodegenerative diseases. Mitochondria function to rapidly...

Showing 1 to 2 of 2 entries