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Successfully Climbing the "STAIRs": Surmounting Failed Translation of Experimental Ischemic Stroke Treatments.

Stroke research and treatment

Kahle MP, Bix GJ.
PMID: 23326759
Stroke Res Treat. 2012;2012:374098. doi: 10.1155/2012/374098. Epub 2012 Dec 30.

The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for...

Perlecan and the blood-brain barrier: beneficial proteolysis?.

Frontiers in pharmacology

Roberts J, Kahle MP, Bix GJ.
PMID: 22936915
Front Pharmacol. 2012 Aug 23;3:155. doi: 10.3389/fphar.2012.00155. eCollection 2012.

The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight junctions, astrocytes, and a basement membrane (BM). Prominent components of the BM extracellular matrix (ECM)...

Showing 1 to 2 of 2 entries