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Human prion protein sequence elements impede cross-species chronic wasting disease transmission.

The Journal of clinical investigation

Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ.
PMID: 25961458
J Clin Invest. 2015 Jun;125(6):2548. doi: 10.1172/JCI82647. Epub 2015 May 11.

No abstract available.

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines.

Pathobiology of aging & age related diseases

Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W.
PMID: 27317189
Pathobiol Aging Age Relat Dis. 2016 Jun 16;6:32397. doi: 10.3402/pba.v6.32397. eCollection 2016.

Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of...

Showing 1 to 2 of 2 entries