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Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?.

Frontiers in neuroscience

Post MR, Lieberman OJ, Mosharov EV.
PMID: 29593491
Front Neurosci. 2018 Mar 14;12:161. doi: 10.3389/fnins.2018.00161. eCollection 2018.

Several lines of evidence place alpha-synuclein (aSyn) at the center of Parkinson's disease (PD) etiology, but it is still unclear why overexpression or mutated forms of this protein affect some neuronal populations more than others. Susceptible neuronal populations in...

An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures.

Frontiers in cellular neuroscience

Lautenschläger J, Mosharov EV, Kanter E, Sulzer D, Kaminski Schierle GS.
PMID: 29556177
Front Cell Neurosci. 2018 Mar 02;12:44. doi: 10.3389/fncel.2018.00044. eCollection 2018.

Postnatally derived cultures of ventral mesencephalic neurons offer several crucial advantages over embryonic ventral mesencephalic cultures, including a higher content of TH-positive cells and the ability to derive cells from the substantia nigra, which contains the neurons most vulnerable...

Showing 1 to 2 of 2 entries