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Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction.

F1000Research

Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P.
PMID: 27303627
F1000Res. 2016 Mar 15;5:353. doi: 10.12688/f1000research.8300.2. eCollection 2016.

Scientific evidence has established several links between metabolic and neurocognitive dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer's disease and vascular dementia in patients with diabetes. In July 2015, the National Institute of Diabetes, Digestive, and...

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.

Molecular neurodegeneration

Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA.
PMID: 20937087
Mol Neurodegener. 2010 Oct 11;5:40. doi: 10.1186/1750-1326-5-40.

BACKGROUND: Retrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5-containing endosomes, mediated by clathrin and the recently characterized retromer complex. This complex and one of its putative sorting receptor components, SorLA,...

Showing 1 to 2 of 2 entries