Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 7 of 7 entries
Sorted by: Best Match Show Resources per page
Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model.

Frontiers in aging neuroscience

Lin Y, Sandusky-Beltran LA, Gamallo-Lana B, Mar A, Sigurdsson EM.
PMID: 32714180
Front Aging Neurosci. 2020 Jul 02;12:205. doi: 10.3389/fnagi.2020.00205. eCollection 2020.

No abstract available.

Cite
Lin Y, Sandusky-Beltran LA, Gamallo-Lana B, et al. Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2020;12:205doi: 10.3389/fnagi.2020.00205.
Lin, Y., Sandusky-Beltran, L. A., Gamallo-Lana, B., Mar, A., & Sigurdsson, E. M. (2020). Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Frontiers in aging neuroscience, 12205. https://doi.org/10.3389/fnagi.2020.00205
Lin, Yan, et al. "Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model." Frontiers in aging neuroscience vol. 12 (2020): 205. doi: https://doi.org/10.3389/fnagi.2020.00205
Lin Y, Sandusky-Beltran LA, Gamallo-Lana B, Mar A, Sigurdsson EM. Response: Commentary: Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2020 Jul 02;12:205. doi: 10.3389/fnagi.2020.00205. eCollection 2020. PMID: 32714180; PMCID: PMC7351512.
Copy Download .nbib Format: NLM
Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice.

Frontiers in endocrinology

Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, Rajamohamedsait WJ, Ahmed N, Krishnaswamy S, Sigurdsson EM.
PMID: 27379014
Front Endocrinol (Lausanne). 2016 Jun 14;7:62. doi: 10.3389/fendo.2016.00062. eCollection 2016.

Type 2 diabetes mellitus is characterized by the deposition of islet amyloid polypeptide (IAPP) as amyloid in islets, a process thought to be toxic to β-cells. To determine the feasibility of targeting these aggregates therapeutically, we vaccinated transgenic (Tg)...

Cite
Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, et al. Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Front Endocrinol (Lausanne). 2016;7:62doi: 10.3389/fendo.2016.00062.
Krishnamurthy, P. K., Rajamohamedsait, H. B., Gonzalez, V., Rajamohamedsait, W. J., Ahmed, N., Krishnaswamy, S., & Sigurdsson, E. M. (2016). Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Frontiers in endocrinology, 762. https://doi.org/10.3389/fendo.2016.00062
Krishnamurthy, Pavan K, et al. "Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice." Frontiers in endocrinology vol. 7 (2016): 62. doi: https://doi.org/10.3389/fendo.2016.00062
Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, Rajamohamedsait WJ, Ahmed N, Krishnaswamy S, Sigurdsson EM. Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Front Endocrinol (Lausanne). 2016 Jun 14;7:62. doi: 10.3389/fendo.2016.00062. eCollection 2016. PMID: 27379014; PMCID: PMC4907063.
Copy Download .nbib Format: NLM
Current Status of Clinical Trials on Tau Immunotherapies.

Drugs

Ji C, Sigurdsson EM.
PMID: 34101156
Drugs. 2021 Jul;81(10):1135-1152. doi: 10.1007/s40265-021-01546-6. Epub 2021 Jun 08.

Tau immunotherapies have advanced from proof-of-concept studies to over a dozen clinical trials for Alzheimer's disease (AD) and other tauopathies. Mechanistic studies in animal and culture models have provided valuable insight into how these therapies may work but multiple...

Cite
Ji C, Sigurdsson EM. Current Status of Clinical Trials on Tau Immunotherapies. Drugs. 2021;81(10):1135-1152doi: 10.1007/s40265-021-01546-6.
Ji, C., & Sigurdsson, E. M. (2021). Current Status of Clinical Trials on Tau Immunotherapies. Drugs, 81(10), 1135-1152. https://doi.org/10.1007/s40265-021-01546-6
Ji, Changyi, and Sigurdsson, Einar M. "Current Status of Clinical Trials on Tau Immunotherapies." Drugs vol. 81,10 (2021): 1135-1152. doi: https://doi.org/10.1007/s40265-021-01546-6
Ji C, Sigurdsson EM. Current Status of Clinical Trials on Tau Immunotherapies. Drugs. 2021 Jul;81(10):1135-1152. doi: 10.1007/s40265-021-01546-6. Epub 2021 Jun 08. PMID: 34101156.
Copy Download .nbib Format: NLM
Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model.

Frontiers in aging neuroscience

Lin Y, Rajamohamedsait HB, Sandusky-Beltran LA, Gamallo-Lana B, Mar A, Sigurdsson EM.
PMID: 31992982
Front Aging Neurosci. 2020 Jan 14;11:377. doi: 10.3389/fnagi.2019.00377. eCollection 2019.

Programmed cell death protein 1 (PD-1) checkpoint blockade with an antibody has been shown to reduce amyloid-β plaques, associated pathologies and cognitive impairment in mouse models. More recently, this approach has shown effectiveness in a tauopathy mouse model to...

Cite
Lin Y, Rajamohamedsait HB, Sandusky-Beltran LA, et al. Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2020;11:377doi: 10.3389/fnagi.2019.00377.
Lin, Y., Rajamohamedsait, H. B., Sandusky-Beltran, L. A., Gamallo-Lana, B., Mar, A., & Sigurdsson, E. M. (2019). Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Frontiers in aging neuroscience, 11377. https://doi.org/10.3389/fnagi.2019.00377
Lin, Yan, et al. "Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model." Frontiers in aging neuroscience vol. 11 (2019): 377. doi: https://doi.org/10.3389/fnagi.2019.00377
Lin Y, Rajamohamedsait HB, Sandusky-Beltran LA, Gamallo-Lana B, Mar A, Sigurdsson EM. Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model. Front Aging Neurosci. 2020 Jan 14;11:377. doi: 10.3389/fnagi.2019.00377. eCollection 2019. PMID: 31992982; PMCID: PMC6971044.
Copy Download .nbib Format: NLM
Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model.

Frontiers in psychiatry

Krishnamurthy PK, Deng Y, Sigurdsson EM.
PMID: 22025915
Front Psychiatry. 2011 Oct 21;2:59. doi: 10.3389/fpsyt.2011.00059. eCollection 2011.

Recent studies have shown that immunotherapy clears amyloid beta (Aβ) plaques and reduces Aβ levels in mouse models of Alzheimer's disease (AD), as well as in AD patients. Tangle pathology is also relevant for the neurodegeneration in AD, and...

Cite
Krishnamurthy PK, Deng Y, Sigurdsson EM. Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Front Psychiatry. 2011;2:59doi: 10.3389/fpsyt.2011.00059.
Krishnamurthy, P. K., Deng, Y., & Sigurdsson, E. M. (2011). Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Frontiers in psychiatry, 259. https://doi.org/10.3389/fpsyt.2011.00059
Krishnamurthy, Pavan K, et al. "Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model." Frontiers in psychiatry vol. 2 (2011): 59. doi: https://doi.org/10.3389/fpsyt.2011.00059
Krishnamurthy PK, Deng Y, Sigurdsson EM. Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Front Psychiatry. 2011 Oct 21;2:59. doi: 10.3389/fpsyt.2011.00059. eCollection 2011. PMID: 22025915; PMCID: PMC3198029.
Copy Download .nbib Format: NLM
Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model.

Frontiers in neurology

Shamir DB, Deng Y, Wu Q, Modak S, Congdon EE, Sigurdsson EM.
PMID: 33324339
Front Neurol. 2020 Nov 26;11:602292. doi: 10.3389/fneur.2020.602292. eCollection 2020.

We and others have shown in various

Cite
Shamir DB, Deng Y, Wu Q, et al. Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model. Front Neurol. 2020;11:602292doi: 10.3389/fneur.2020.602292.
Shamir, D. B., Deng, Y., Wu, Q., Modak, S., Congdon, E. E., & Sigurdsson, E. M. (2020). Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model. Frontiers in neurology, 11602292. https://doi.org/10.3389/fneur.2020.602292
Shamir, Dov B, et al. "Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model." Frontiers in neurology vol. 11 (2020): 602292. doi: https://doi.org/10.3389/fneur.2020.602292
Shamir DB, Deng Y, Wu Q, Modak S, Congdon EE, Sigurdsson EM. Dynamics of Internalization and Intracellular Interaction of Tau Antibodies and Human Pathological Tau Protein in a Human Neuron-Like Model. Front Neurol. 2020 Nov 26;11:602292. doi: 10.3389/fneur.2020.602292. eCollection 2020. PMID: 33324339; PMCID: PMC7727311.
Copy Download .nbib Format: NLM
Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Sexton CE, Anstey KJ, Baldacci F, Barnum CJ, Barron AM, Blennow K, Brodaty H, Burnham S, Elahi FM, Götz J, Jeon YH, Koronyo-Hamaoui M, Landau SM, Lautenschlager NT, Laws SM, Lipnicki DM, Lu H, Masters CL, Moyle W, Nakamura A, Pasinetti GM, Rao N, Rowe C, Sachdev PS, Schofield PR, Sigurdsson EM, Smith K, Srikanth V, Szoeke C, Tansey MG, Whitmer R, Wilcock D, Wong TY, Bain LJ, Carrillo MC.
PMID: 34058063
Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12380. Epub 2021 May 31.

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes...

Cite
Sexton CE, Anstey KJ, Baldacci F, et al. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimers Dement. 2021;doi: 10.1002/alz.12380.
Sexton, C. E., Anstey, K. J., Baldacci, F., Barnum, C. J., Barron, A. M., Blennow, K., Brodaty, H., Burnham, S., Elahi, F. M., Götz, J., Jeon, Y. H., Koronyo-Hamaoui, M., Landau, S. M., Lautenschlager, N. T., Laws, S. M., Lipnicki, D. M., Lu, H., Masters, C. L., Moyle, W., Nakamura, A., Pasinetti, G. M., Rao, N., Rowe, C., Sachdev, P. S., Schofield, P. R., Sigurdsson, E. M., Smith, K., Srikanth, V., Szoeke, C., Tansey, M. G., Whitmer, R., Wilcock, D., Wong, T. Y., Bain, L. J., & Carrillo, M. C. (2021). Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12380
Sexton, Claire E, et al. "Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12380
Sexton CE, Anstey KJ, Baldacci F, Barnum CJ, Barron AM, Blennow K, Brodaty H, Burnham S, Elahi FM, Götz J, Jeon YH, Koronyo-Hamaoui M, Landau SM, Lautenschlager NT, Laws SM, Lipnicki DM, Lu H, Masters CL, Moyle W, Nakamura A, Pasinetti GM, Rao N, Rowe C, Sachdev PS, Schofield PR, Sigurdsson EM, Smith K, Srikanth V, Szoeke C, Tansey MG, Whitmer R, Wilcock D, Wong TY, Bain LJ, Carrillo MC. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12380. Epub 2021 May 31. PMID: 34058063.
Copy Download .nbib Format: NLM
Showing 1 to 7 of 7 entries