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Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.

Nature communications

Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C.
PMID: 34675202
Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z.

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same...

Cite
Gordillo-Marañón M, Zwierzyna M, Charoen P, et al. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun. 2021;12(1):6120doi: 10.1038/s41467-021-25731-z.
Gordillo-Marañón, M., Zwierzyna, M., Charoen, P., Drenos, F., Chopade, S., Shah, T., Engmann, J., Chaturvedi, N., Papacosta, O., Wannamethee, G., Wong, A., Sofat, R., Kivimaki, M., Price, J. F., Hughes, A. D., Gaunt, T. R., Lawlor, D. A., Gaulton, A., Hingorani, A. D., Schmidt, A. F., & Finan, C. (2021). Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nature communications, 12(1), 6120. https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón, María, et al. "Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics." Nature communications vol. 12,1 (2021): 6120. doi: https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics. Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z. PMID: 34675202; PMCID: PMC8531035.
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Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging.

Human brain mapping

Anatürk M, Kaufmann T, Cole JH, Suri S, Griffanti L, Zsoldos E, Filippini N, Singh-Manoux A, Kivimäki M, Westlye LT, Ebmeier KP, de Lange AG.
PMID: 33314530
Hum Brain Mapp. 2021 Apr 15;42(6):1626-1640. doi: 10.1002/hbm.25316. Epub 2020 Dec 14.

The concept of brain maintenance refers to the preservation of brain integrity in older age, while cognitive reserve refers to the capacity to maintain cognition in the presence of neurodegeneration or aging-related brain changes. While both mechanisms are thought...

Cite
Anatürk M, Kaufmann T, Cole JH, et al. Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Hum Brain Mapp. 2020;42(6):1626-1640doi: 10.1002/hbm.25316.
Anatürk, M., Kaufmann, T., Cole, J. H., Suri, S., Griffanti, L., Zsoldos, E., Filippini, N., Singh-Manoux, A., Kivimäki, M., Westlye, L. T., Ebmeier, K. P., & de Lange, A. G. (2021). Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Human brain mapping, 42(6), 1626-1640. https://doi.org/10.1002/hbm.25316
Anatürk, Melis, et al. "Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging." Human brain mapping vol. 42,6 (2021): 1626-1640. doi: https://doi.org/10.1002/hbm.25316
Anatürk M, Kaufmann T, Cole JH, Suri S, Griffanti L, Zsoldos E, Filippini N, Singh-Manoux A, Kivimäki M, Westlye LT, Ebmeier KP, de Lange AG. Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging. Hum Brain Mapp. 2021 Apr 15;42(6):1626-1640. doi: 10.1002/hbm.25316. Epub 2020 Dec 14. PMID: 33314530; PMCID: PMC7978127.
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