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Showing 1 to 5 of 5 entries
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African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.

Neurology. Genetics

Schindler SE, Cruchaga C, Joseph A, McCue L, Farias FHG, Wilkins CH, Deming Y, Henson RL, Mikesell RJ, Piccio L, Llibre-Guerra JJ, Moulder KL, Fagan AM, Ances BM, Benzinger TLS, Xiong C, Holtzman DM, Morris JC.
PMID: 33884297
Neurol Genet. 2021 Mar 04;7(2):e571. doi: 10.1212/NXG.0000000000000571. eCollection 2021 Apr.

OBJECTIVE: To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in...

Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25.

Neurobiology of aging

Butt OH, Long JM, Henson RL, Herries E, Sutphen CL, Fagan AM, Cruchaga C, Ladenson JH, Holtzman DM, Morris JC, Ances BM, Schindler SE.
PMID: 33765432
Neurobiol Aging. 2021 Jun;102:64-72. doi: 10.1016/j.neurobiolaging.2021.02.008. Epub 2021 Feb 11.

Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) and neurogranin (Ng) are recently described biomarkers for pre- and postsynaptic integrity known to be elevated in symptomatic Alzheimer disease (AD). Their relationship with Apolipoprotein E (APOE) ε4 carrier status, the major...

Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET.

Neurology

Schindler SE, Li Y, Buckles VD, Gordon BA, Benzinger TLS, Wang G, Coble D, Klunk WE, Fagan AM, Holtzman DM, Bateman RJ, Morris JC, Xiong C.
PMID: 34504028
Neurology. 2021 Nov 02;97(18):e1823-e1834. doi: 10.1212/WNL.0000000000012775. Epub 2021 Sep 09.

BACKGROUND AND OBJECTIVES: To predict when cognitively normal individuals with brain amyloidosis will develop symptoms of Alzheimer disease (AD).METHODS: Brain amyloid burden was measured by amyloid PET with Pittsburgh compound B. The mean cortical standardized uptake value ratio (SUVR)...

Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET.

Neurology

Schindler SE, Li Y, Buckles VD, Gordon BA, Benzinger TLS, Wang G, Coble D, Klunk WE, Fagan AM, Holtzman DM, Bateman RJ, Morris JC, Xiong C.
PMID: 34504028
Neurology. 2021 Nov 02;97(18):e1823-e1834. doi: 10.1212/WNL.0000000000012775. Epub 2021 Sep 09.

BACKGROUND AND OBJECTIVES: To predict when cognitively normal individuals with brain amyloidosis will develop symptoms of Alzheimer disease (AD).METHODS: Brain amyloid burden was measured by amyloid PET with Pittsburgh compound B. The mean cortical standardized uptake value ratio (SUVR)...

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.

Neurology. Genetics

Schindler SE, Cruchaga C, Joseph A, McCue L, Farias FHG, Wilkins CH, Deming Y, Henson RL, Mikesell RJ, Piccio L, Llibre-Guerra JJ, Moulder KL, Fagan AM, Ances BM, Benzinger TLS, Xiong C, Holtzman DM, Morris JC.
PMID: 33884297
Neurol Genet. 2021 Mar 04;7(2):e571. doi: 10.1212/NXG.0000000000000571. eCollection 2021 Apr.

OBJECTIVE: To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in...

Showing 1 to 5 of 5 entries