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ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism.

Signal transduction and targeted therapy

Berman AY, Manna S, Schwartz NS, Katz YE, Sun Y, Behrmann CA, Yu JJ, Plas DR, Alayev A, Holz MK.
PMID: 28890840
Signal Transduct Target Ther. 2017;2. doi: 10.1038/sigtrans.2017.35. Epub 2017 Aug 25.

Estrogen-related receptor alpha (ERRα) is an orphan nuclear factor that is a master regulator of cellular energy metabolism. ERRα is overexpressed in a variety of tumors, including ovarian, prostate, colorectal, cervical and breast, and is associated with a more...

The therapeutic potential of resveratrol: a review of clinical trials.

NPJ precision oncology

Berman AY, Motechin RA, Wiesenfeld MY, Holz MK.
PMID: 28989978
NPJ Precis Oncol. 2017;1. doi: 10.1038/s41698-017-0038-6. Epub 2017 Sep 25.

Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms. While there is a...

Tamoxifen Action in ER-Negative Breast Cancer.

Signal transduction insights

Manna S, Holz MK.
PMID: 26989346
Sign Transduct Insights. 2016 Feb 10;5:1-7. doi: 10.4137/STI.S29901.

Breast cancer is a highly heterogeneous disease. Tamoxifen is a selective estrogen receptor (ER) modulator and is mainly indicated for the treatment of breast cancer in postmenopausal women and postsurgery neoadjuvant therapy in ER-positive breast cancers. Interestingly, 5-10% of...

Showing 1 to 3 of 3 entries