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Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice.

Frontiers in endocrinology

Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, Rajamohamedsait WJ, Ahmed N, Krishnaswamy S, Sigurdsson EM.
PMID: 27379014
Front Endocrinol (Lausanne). 2016 Jun 14;7:62. doi: 10.3389/fendo.2016.00062. eCollection 2016.

Type 2 diabetes mellitus is characterized by the deposition of islet amyloid polypeptide (IAPP) as amyloid in islets, a process thought to be toxic to β-cells. To determine the feasibility of targeting these aggregates therapeutically, we vaccinated transgenic (Tg)...

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Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, et al. Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Front Endocrinol (Lausanne). 2016;7:62doi: 10.3389/fendo.2016.00062.
Krishnamurthy, P. K., Rajamohamedsait, H. B., Gonzalez, V., Rajamohamedsait, W. J., Ahmed, N., Krishnaswamy, S., & Sigurdsson, E. M. (2016). Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Frontiers in endocrinology, 762. https://doi.org/10.3389/fendo.2016.00062
Krishnamurthy, Pavan K, et al. "Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice." Frontiers in endocrinology vol. 7 (2016): 62. doi: https://doi.org/10.3389/fendo.2016.00062
Krishnamurthy PK, Rajamohamedsait HB, Gonzalez V, Rajamohamedsait WJ, Ahmed N, Krishnaswamy S, Sigurdsson EM. Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice. Front Endocrinol (Lausanne). 2016 Jun 14;7:62. doi: 10.3389/fendo.2016.00062. eCollection 2016. PMID: 27379014; PMCID: PMC4907063.
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Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model.

Frontiers in psychiatry

Krishnamurthy PK, Deng Y, Sigurdsson EM.
PMID: 22025915
Front Psychiatry. 2011 Oct 21;2:59. doi: 10.3389/fpsyt.2011.00059. eCollection 2011.

Recent studies have shown that immunotherapy clears amyloid beta (Aβ) plaques and reduces Aβ levels in mouse models of Alzheimer's disease (AD), as well as in AD patients. Tangle pathology is also relevant for the neurodegeneration in AD, and...

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Krishnamurthy PK, Deng Y, Sigurdsson EM. Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Front Psychiatry. 2011;2:59doi: 10.3389/fpsyt.2011.00059.
Krishnamurthy, P. K., Deng, Y., & Sigurdsson, E. M. (2011). Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Frontiers in psychiatry, 259. https://doi.org/10.3389/fpsyt.2011.00059
Krishnamurthy, Pavan K, et al. "Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model." Frontiers in psychiatry vol. 2 (2011): 59. doi: https://doi.org/10.3389/fpsyt.2011.00059
Krishnamurthy PK, Deng Y, Sigurdsson EM. Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model. Front Psychiatry. 2011 Oct 21;2:59. doi: 10.3389/fpsyt.2011.00059. eCollection 2011. PMID: 22025915; PMCID: PMC3198029.
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Showing 1 to 2 of 2 entries