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The role of phosphoinositide 3-kinase signaling in intestinal inflammation.

Journal of signal transduction

Cahill CM, Rogers JT, Walker WA.
PMID: 22570785
J Signal Transduct. 2012;2012:358476. doi: 10.1155/2012/358476. Epub 2012 Apr 09.

The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling...

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease.

Frontiers in neuroscience

Lumsden AL, Rogers JT, Majd S, Newman M, Sutherland GT, Verdile G, Lardelli M.
PMID: 30150923
Front Neurosci. 2018 Aug 13;12:533. doi: 10.3389/fnins.2018.00533. eCollection 2018.

The overwhelming majority of dominant mutations causing early onset familial Alzheimer's disease (EOfAD) occur in only three genes,

The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression.

Parkinson's disease

Mikkilineni S, Cantuti-Castelvetri I, Cahill CM, Balliedier A, Greig NH, Rogers JT.
PMID: 22693681
Parkinsons Dis. 2012;2012:142372. doi: 10.1155/2012/142372. Epub 2012 May 29.

There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients. An increase of SNCA gene copy number can genetically cause familial PD where increased dose of this pathogenic protein correlates with...

Showing 1 to 3 of 3 entries