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Showing 1 to 8 of 8 entries
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Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas.

Cancers

Mittal K, Choi DH, Wei G, Kaur J, Klimov S, Arora K, Griffith CC, Kumar M, Imhansi-Jacob P, Melton BD, Bhimji-Pattni S, Osan RM, Rida P, Golusinski P, Aneja R.
PMID: 32102296
Cancers (Basel). 2020 Feb 24;12(2). doi: 10.3390/cancers12020517.

Human papillomavirus-negative (HPV-neg) oropharyngeal squamous cell carcinomas (OPSCCs) are associated with poorer overall survival (OS) compared with HPV-positive (HPV-pos) OPSCCs. The major obstacle in improving outcomes of HPV-neg patients is the lack of robust biomarkers and therapeutic targets. Herein,...

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Mittal K, Choi DH, Wei G, et al. Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas. Cancers (Basel). 2020;12(2)doi: 10.3390/cancers12020517.
Mittal, K., Choi, D. H., Wei, G., Kaur, J., Klimov, S., Arora, K., Griffith, C. C., Kumar, M., Imhansi-Jacob, P., Melton, B. D., Bhimji-Pattni, S., Osan, R. M., Rida, P., Golusinski, P., & Aneja, R. (2020). Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas. Cancers, 12(2), . https://doi.org/10.3390/cancers12020517
Mittal, Karuna, et al. "Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas." Cancers vol. 12,2 (2020). doi: https://doi.org/10.3390/cancers12020517
Mittal K, Choi DH, Wei G, Kaur J, Klimov S, Arora K, Griffith CC, Kumar M, Imhansi-Jacob P, Melton BD, Bhimji-Pattni S, Osan RM, Rida P, Golusinski P, Aneja R. Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas. Cancers (Basel). 2020 Feb 24;12(2). doi: 10.3390/cancers12020517. PMID: 32102296; PMCID: PMC7072660.
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Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes.

Pathogens (Basel, Switzerland)

Rothan HA, Kumar M.
PMID: 31547236
Pathogens. 2019 Sep 12;8(3). doi: 10.3390/pathogens8030148.

Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified...

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Rothan HA, Kumar M. Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes. Pathogens. 2019;8(3)doi: 10.3390/pathogens8030148.
Rothan, H. A., & Kumar, M. (2019). Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes. Pathogens (Basel, Switzerland), 8(3), . https://doi.org/10.3390/pathogens8030148
Rothan, Hussin A, and Kumar, Mukesh. "Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes." Pathogens (Basel, Switzerland) vol. 8,3 (2019). doi: https://doi.org/10.3390/pathogens8030148
Rothan HA, Kumar M. Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes. Pathogens. 2019 Sep 12;8(3). doi: 10.3390/pathogens8030148. PMID: 31547236; PMCID: PMC6789530.
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Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice.

Frontiers in microbiology

Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M.
PMID: 30814992
Front Microbiol. 2019 Feb 13;10:259. doi: 10.3389/fmicb.2019.00259. eCollection 2019.

West Nile virus (WNV) is an enveloped positive-stranded RNA virus that causes meningitis, encephalitis, and acute flaccid paralysis in humans. There are no therapeutic agents available for use against WNV infection. Alpha-2 macroglobulin (A2M) is a major plasma proteinase...

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Krause K, Azouz F, Nakano E, et al. Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Front Microbiol. 2019;10:259doi: 10.3389/fmicb.2019.00259.
Krause, K., Azouz, F., Nakano, E., Nerurkar, V. R., & Kumar, M. (2019). Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Frontiers in microbiology, 10259. https://doi.org/10.3389/fmicb.2019.00259
Krause, Keeton, et al. "Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice." Frontiers in microbiology vol. 10 (2019): 259. doi: https://doi.org/10.3389/fmicb.2019.00259
Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M. Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Front Microbiol. 2019 Feb 13;10:259. doi: 10.3389/fmicb.2019.00259. eCollection 2019. PMID: 30814992; PMCID: PMC6381297.
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Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice.

mSphere

To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT.
PMID: 29359186
mSphere. 2018 Jan 10;3(1). doi: 10.1128/mSphere.00576-17. eCollection 2018.

Following the 2015 Zika virus (ZIKV) outbreaks in the South Pacific, Caribbean, and Americas, ZIKV has emerged as a serious threat due to its association with infantile microcephaly and other neurologic disorders. Despite an international effort to develop a...

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To A, Medina LO, Mfuh KO, et al. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere. 2018;3(1)doi: 10.1128/mSphere.00576-17.
To, A., Medina, L. O., Mfuh, K. O., Lieberman, M. M., Wong, T. A. S., Namekar, M., Nakano, E., Lai, C. Y., Kumar, M., Nerurkar, V. R., & Lehrer, A. T. (2018). Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere, 3(1), . https://doi.org/10.1128/mSphere.00576-17
To, Albert, et al. "Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice." mSphere vol. 3,1 (2018). doi: https://doi.org/10.1128/mSphere.00576-17
To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere. 2018 Jan 10;3(1). doi: 10.1128/mSphere.00576-17. eCollection 2018. PMID: 29359186; PMCID: PMC5760751.
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Computational study of novel inhibitory molecule, 1-(4-((2.

Journal of biomolecular structure & dynamics

Sharma PP, Kumar S, Srivastava S, Srivastava M, Jee B, Gorobets NY, Kumar D, Kumar M, Asthana S, Zhang P, Poonam, Zoltner M, Rathi B.
PMID: 34151735
J Biomol Struct Dyn. 2021 Jun 21;1-19. doi: 10.1080/07391102.2021.1940281. Epub 2021 Jun 21.

For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive

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Sharma PP, Kumar S, Srivastava S, et al. Computational study of novel inhibitory molecule, 1-(4-((2. J Biomol Struct Dyn. 2021;1-19doi: 10.1080/07391102.2021.1940281.
Sharma, P. P., Kumar, S., Srivastava, S., Srivastava, M., Jee, B., Gorobets, N. Y., Kumar, D., Kumar, M., Asthana, S., Zhang, P., Poonam, Zoltner, M., & Rathi, B. (2021). Computational study of novel inhibitory molecule, 1-(4-((2. Journal of biomolecular structure & dynamics, 1-19. https://doi.org/10.1080/07391102.2021.1940281
Sharma, Prem Prakash, et al. "Computational study of novel inhibitory molecule, 1-(4-((2." Journal of biomolecular structure & dynamics vol. (2021): 1-19. doi: https://doi.org/10.1080/07391102.2021.1940281
Sharma PP, Kumar S, Srivastava S, Srivastava M, Jee B, Gorobets NY, Kumar D, Kumar M, Asthana S, Zhang P, Poonam, Zoltner M, Rathi B. Computational study of novel inhibitory molecule, 1-(4-((2. J Biomol Struct Dyn. 2021 Jun 21;1-19. doi: 10.1080/07391102.2021.1940281. Epub 2021 Jun 21. PMID: 34151735.
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Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis.

Frontiers in microbiology

Rothan HA, Arora K, Natekar JP, Strate PG, Brinton MA, Kumar M.
PMID: 31572318
Front Microbiol. 2019 Sep 11;10:2089. doi: 10.3389/fmicb.2019.02089. eCollection 2019.

West Nile virus (WNV), a neurotropic flavivirus, is the leading cause of viral encephalitis in the United States. Recently, Zika virus (ZIKV) infections have caused serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome and microcephaly. Z-DNA binding protein...

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Rothan HA, Arora K, Natekar JP, et al. Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis. Front Microbiol. 2019;10:2089doi: 10.3389/fmicb.2019.02089.
Rothan, H. A., Arora, K., Natekar, J. P., Strate, P. G., Brinton, M. A., & Kumar, M. (2019). Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis. Frontiers in microbiology, 102089. https://doi.org/10.3389/fmicb.2019.02089
Rothan, Hussin A, et al. "Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis." Frontiers in microbiology vol. 10 (2019): 2089. doi: https://doi.org/10.3389/fmicb.2019.02089
Rothan HA, Arora K, Natekar JP, Strate PG, Brinton MA, Kumar M. Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis. Front Microbiol. 2019 Sep 11;10:2089. doi: 10.3389/fmicb.2019.02089. eCollection 2019. PMID: 31572318; PMCID: PMC6749019.
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Molecular Aspects of COVID-19 Differential Pathogenesis.

Pathogens (Basel, Switzerland)

Rothan HA, Acharya A, Reid SP, Kumar M, Byrareddy SN.
PMID: 32640525
Pathogens. 2020 Jul 06;9(7). doi: 10.3390/pathogens9070538.

In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt...

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Rothan HA, Acharya A, Reid SP, et al. Molecular Aspects of COVID-19 Differential Pathogenesis. Pathogens. 2020;9(7)doi: 10.3390/pathogens9070538.
Rothan, H. A., Acharya, A., Reid, S. P., Kumar, M., & Byrareddy, S. N. (2020). Molecular Aspects of COVID-19 Differential Pathogenesis. Pathogens (Basel, Switzerland), 9(7), . https://doi.org/10.3390/pathogens9070538
Rothan, Hussin A, et al. "Molecular Aspects of COVID-19 Differential Pathogenesis." Pathogens (Basel, Switzerland) vol. 9,7 (2020). doi: https://doi.org/10.3390/pathogens9070538
Rothan HA, Acharya A, Reid SP, Kumar M, Byrareddy SN. Molecular Aspects of COVID-19 Differential Pathogenesis. Pathogens. 2020 Jul 06;9(7). doi: 10.3390/pathogens9070538. PMID: 32640525; PMCID: PMC7400297.
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Understanding the Pathogenesis of Zika Virus Infection Using Animal Models.

Immune network

Krause KK, Azouz F, Shin OS, Kumar M.
PMID: 29093650
Immune Netw. 2017 Oct;17(5):287-297. doi: 10.4110/in.2017.17.5.287. Epub 2017 Oct 19.

Zika virus (ZIKV) is a member of

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Krause KK, Azouz F, Shin OS, et al. Understanding the Pathogenesis of Zika Virus Infection Using Animal Models. Immune Netw. 2017;17(5):287-297doi: 10.4110/in.2017.17.5.287.
Krause, K. K., Azouz, F., Shin, O. S., & Kumar, M. (2017). Understanding the Pathogenesis of Zika Virus Infection Using Animal Models. Immune network, 17(5), 287-297. https://doi.org/10.4110/in.2017.17.5.287
Krause, Keeton K, et al. "Understanding the Pathogenesis of Zika Virus Infection Using Animal Models." Immune network vol. 17,5 (2017): 287-297. doi: https://doi.org/10.4110/in.2017.17.5.287
Krause KK, Azouz F, Shin OS, Kumar M. Understanding the Pathogenesis of Zika Virus Infection Using Animal Models. Immune Netw. 2017 Oct;17(5):287-297. doi: 10.4110/in.2017.17.5.287. Epub 2017 Oct 19. PMID: 29093650; PMCID: PMC5662778.
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Showing 1 to 8 of 8 entries