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Mephedrone alters basal ganglia and limbic dynorphin systems.

Synapse (New York, N.Y.)

German CL, Alburges ME, Hoonakker AJ, Fleckenstein AE, Hanson GR.
PMID: 25155699
Synapse. 2014 Dec;68(12):634-640. doi: 10.1002/syn.21778. Epub 2014 Sep 08.

Mephedrone (4-methymethcathinone) is a synthetic cathinone designer drug that disrupts central nervous system (CNS) dopamine (DA) signaling. Numerous central neuropeptide systems reciprocally interact with dopaminergic neurons to provide regulatory counterbalance, and are altered by aberrant DA activity associated with...

Neuropharmacological mechanisms underlying the neuroprotective effects of methylphenidate.

Current neuropharmacology

Volz TJ.
PMID: 19587858
Curr Neuropharmacol. 2008 Dec;6(4):379-85. doi: 10.2174/157015908787386041.

Methylphenidate is a psychostimulant that inhibits the neuronal dopamine transporter. In addition, methylphenidate has the intriguing ability to provide neuroprotection from the neurotoxic effects of methamphetamine and perhaps also Parkinson's disease; both of which may likely involve the abnormal...

Showing 1 to 2 of 2 entries