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Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination.

Cold Spring Harbor symposia on quantitative biology

Tatomer DC, Wilusz JE.
PMID: 32086332
Cold Spring Harb Symp Quant Biol. 2019;84:83-93. doi: 10.1101/sqb.2019.84.039644. Epub 2020 Feb 21.

A complex network of RNA transcripts is generated from eukaryotic genomes, many of which are processed in unexpected ways. Here, we highlight how premature transcription termination events at protein-coding gene loci can simultaneously lead to the generation of short...

Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events.

Methods (San Diego, Calif.)

Liang D, Tatomer DC, Wilusz JE.
PMID: 33882363
Methods. 2021 Dec;196:121-128. doi: 10.1016/j.ymeth.2021.04.012. Epub 2021 Apr 18.

Circular RNAs with covalently linked ends are generated from many eukaryotic protein-coding genes when the pre-mRNA splicing machinery backsplices. These mature transcripts are resistant to digestion by exonucleases and typically have much longer half-lives than their associated linear mRNAs....

Showing 1 to 3 of 3 entries