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Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection.

Disease models & mechanisms

Bhatt K, Bhagavathula M, Verma S, Timmins GS, Deretic VP, Ellner JJ, Salgame P.
PMID: 34486033
Dis Model Mech. 2021 Oct 01;14(10). doi: 10.1242/dmm.049018. Epub 2021 Oct 26.

Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing the risk for relapse and...

Cite
Bhatt K, Bhagavathula M, Verma S, et al. Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Dis Model Mech. 2021;14(10)doi: 10.1242/dmm.049018.
Bhatt, K., Bhagavathula, M., Verma, S., Timmins, G. S., Deretic, V. P., Ellner, J. J., & Salgame, P. (2021). Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Disease models & mechanisms, 14(10), . https://doi.org/10.1242/dmm.049018
Bhatt, Kamlesh, et al. "Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection." Disease models & mechanisms vol. 14,10 (2021). doi: https://doi.org/10.1242/dmm.049018
Bhatt K, Bhagavathula M, Verma S, Timmins GS, Deretic VP, Ellner JJ, Salgame P. Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Dis Model Mech. 2021 Oct 01;14(10). doi: 10.1242/dmm.049018. Epub 2021 Oct 26. PMID: 34486033; PMCID: PMC8560501.
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Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB.

Autophagy

Kumar S, Jain A, Choi SW, Peixoto Duarte da Silva G, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V.
PMID: 33070669
Autophagy. 2020 Dec;16(12):2305-2306. doi: 10.1080/15548627.2020.1837423. Epub 2020 Nov 10.

Macroautophagy/autophagy delivers cytoplasmic cargo to lysosomes for degradation. In yeast, the single Atg8 protein plays a role in the formation of autophagosomes whereas in mammalian cells there are five to seven paralogs, referred to as mammalian Atg8s (mAtg8s: GABARAP,...

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Kumar S, Jain A, Choi SW, et al. Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB. Autophagy. 2020;16(12):2305-2306doi: 10.1080/15548627.2020.1837423.
Kumar, S., Jain, A., Choi, S. W., Peixoto Duarte da Silva, G., Allers, L., Mudd, M. H., Peters, R. S., Anonsen, J. H., Rusten, T. E., Lazarou, M., & Deretic, V. (2020). Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB. Autophagy, 16(12), 2305-2306. https://doi.org/10.1080/15548627.2020.1837423
Kumar, Suresh, et al. "Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB." Autophagy vol. 16,12 (2020): 2305-2306. doi: https://doi.org/10.1080/15548627.2020.1837423
Kumar S, Jain A, Choi SW, Peixoto Duarte da Silva G, Allers L, Mudd MH, Peters RS, Anonsen JH, Rusten TE, Lazarou M, Deretic V. Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB. Autophagy. 2020 Dec;16(12):2305-2306. doi: 10.1080/15548627.2020.1837423. Epub 2020 Nov 10. PMID: 33070669; PMCID: PMC7751677.
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Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes.

Cell

Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V.
PMID: 34741801
Cell. 2021 Nov 24;184(24):5950-5969.e22. doi: 10.1016/j.cell.2021.10.017. Epub 2021 Nov 05.

The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used cellular and in vitro membrane fusion analyses to show that autophagosomes are formed from a hitherto unappreciated hybrid membrane compartment. The autophagic precursors emerge through fusion...

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Kumar S, Javed R, Mudd M, et al. Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell. 2021;184(24):5950-5969.e22doi: 10.1016/j.cell.2021.10.017.
Kumar, S., Javed, R., Mudd, M., Pallikkuth, S., Lidke, K. A., Jain, A., Tangavelou, K., Gudmundsson, S. R., Ye, C., Rusten, T. E., Anonsen, J. H., Lystad, A. H., Claude-Taupin, A., Simonsen, A., Salemi, M., Phinney, B., Li, J., Guo, L. W., Bradfute, S. B., Timmins, G. S., Eskelinen, E. L., & Deretic, V. (2021). Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell, 184(24), 5950-5969.e22. https://doi.org/10.1016/j.cell.2021.10.017
Kumar, Suresh, et al. "Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes." Cell vol. 184,24 (2021): 5950-5969.e22. doi: https://doi.org/10.1016/j.cell.2021.10.017
Kumar S, Javed R, Mudd M, Pallikkuth S, Lidke KA, Jain A, Tangavelou K, Gudmundsson SR, Ye C, Rusten TE, Anonsen JH, Lystad AH, Claude-Taupin A, Simonsen A, Salemi M, Phinney B, Li J, Guo LW, Bradfute SB, Timmins GS, Eskelinen EL, Deretic V. Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. Cell. 2021 Nov 24;184(24):5950-5969.e22. doi: 10.1016/j.cell.2021.10.017. Epub 2021 Nov 05. PMID: 34741801; PMCID: PMC8616855.
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Atg8ylation as a general membrane stress and remodeling response.

Cell stress

Kumar S, Jia J, Deretic V.
PMID: 34527862
Cell Stress. 2021 Aug 12;5(9):128-142. doi: 10.15698/cst2021.09.255. eCollection 2021 Sep.

The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are found on cellular membranes other...

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Kumar S, Jia J, Deretic V. Atg8ylation as a general membrane stress and remodeling response. Cell Stress. 2021;5(9):128-142doi: 10.15698/cst2021.09.255.
Kumar, S., Jia, J., & Deretic, V. (2021). Atg8ylation as a general membrane stress and remodeling response. Cell stress, 5(9), 128-142. https://doi.org/10.15698/cst2021.09.255
Kumar, Suresh, et al. "Atg8ylation as a general membrane stress and remodeling response." Cell stress vol. 5,9 (2021): 128-142. doi: https://doi.org/10.15698/cst2021.09.255
Kumar S, Jia J, Deretic V. Atg8ylation as a general membrane stress and remodeling response. Cell Stress. 2021 Aug 12;5(9):128-142. doi: 10.15698/cst2021.09.255. eCollection 2021 Sep. PMID: 34527862; PMCID: PMC8404385.
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A master conductor for aggregate clearance by autophagy.

Developmental cell

Deretic V.
PMID: 20493804
Dev Cell. 2010 May 18;18(5):694-6. doi: 10.1016/j.devcel.2010.04.009.

Autophagic adapters including p62/SQSTM1 recognize polyubiquitinated targets such as toxic protein aggregates. In a recent issue of Molecular Cell, Filimonenko et al. provide evidence that the phosphatidylinositol 3-phosphate (PI3P) binding protein, Alfy, interacts with p62, Atg5, and PI3P to...

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Deretic V. A master conductor for aggregate clearance by autophagy. Dev Cell. 2010;18(5):694-6doi: 10.1016/j.devcel.2010.04.009.
Deretic, V. (2010). A master conductor for aggregate clearance by autophagy. Developmental cell, 18(5), 694-6. https://doi.org/10.1016/j.devcel.2010.04.009
Deretic, Vojo. "A master conductor for aggregate clearance by autophagy." Developmental cell vol. 18,5 (2010): 694-6. doi: https://doi.org/10.1016/j.devcel.2010.04.009
Deretic V. A master conductor for aggregate clearance by autophagy. Dev Cell. 2010 May 18;18(5):694-6. doi: 10.1016/j.devcel.2010.04.009. PMID: 20493804; PMCID: PMC2974899.
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Autophagy of intracellular microbes and mitochondria: two sides of the same coin?.

F1000 biology reports

Deretic V.
PMID: 20948788
F1000 Biol Rep. 2010 Jun 23;2. doi: 10.3410/B2-45.

Autophagy has become a biological paradigm of how eukaryotic cells, especially those that are long lived, maintain their vitality, control the quality of cytoplasmic organelles, and stay alive or die when growth factors are withdrawn and there is an...

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Deretic V. Autophagy of intracellular microbes and mitochondria: two sides of the same coin?. F1000 Biol Rep. 2010;2doi: 10.3410/B2-45.
Deretic, V. (2010). Autophagy of intracellular microbes and mitochondria: two sides of the same coin?. F1000 biology reports, 2. https://doi.org/10.3410/B2-45
Deretic, Vojo. "Autophagy of intracellular microbes and mitochondria: two sides of the same coin?." F1000 biology reports vol. 2 (2010). doi: https://doi.org/10.3410/B2-45
Deretic V. Autophagy of intracellular microbes and mitochondria: two sides of the same coin?. F1000 Biol Rep. 2010 Jun 23;2. doi: 10.3410/B2-45. PMID: 20948788; PMCID: PMC2950027.
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Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection.

Disease models & mechanisms

Bhatt K, Bhagavathula M, Verma S, Timmins GS, Deretic VP, Ellner JJ, Salgame P.
PMID: 34486033
Dis Model Mech. 2021 Oct 01;14(10). doi: 10.1242/dmm.049018. Epub 2021 Oct 26.

Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing the risk for relapse and...

Cite
Bhatt K, Bhagavathula M, Verma S, et al. Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Dis Model Mech. 2021;14(10)doi: 10.1242/dmm.049018.
Bhatt, K., Bhagavathula, M., Verma, S., Timmins, G. S., Deretic, V. P., Ellner, J. J., & Salgame, P. (2021). Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Disease models & mechanisms, 14(10), . https://doi.org/10.1242/dmm.049018
Bhatt, Kamlesh, et al. "Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection." Disease models & mechanisms vol. 14,10 (2021). doi: https://doi.org/10.1242/dmm.049018
Bhatt K, Bhagavathula M, Verma S, Timmins GS, Deretic VP, Ellner JJ, Salgame P. Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection. Dis Model Mech. 2021 Oct 01;14(10). doi: 10.1242/dmm.049018. Epub 2021 Oct 26. PMID: 34486033; PMCID: PMC8560501.
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Showing 1 to 7 of 7 entries