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Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.

Frontiers in genetics

Voruganti VS, Kent JW, Debnath S, Cole SA, Haack K, Göring HH, Carless MA, Curran JE, Johnson MP, Almasy L, Dyer TD, Maccluer JW, Moses EK, Abboud HE, Mahaney MC, Blangero J, Comuzzie AG.
PMID: 24379826
Front Genet. 2013 Dec 16;4:279. doi: 10.3389/fgene.2013.00279. eCollection 2013.

Increased serum uric acid (SUA) is a risk factor for gout and renal and cardiovascular disease (CVD). The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of...

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Voruganti VS, Kent JW, Debnath S, et al. Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Front Genet. 2013;4:279doi: 10.3389/fgene.2013.00279.
Voruganti, V. S., Kent, J. W., Debnath, S., Cole, S. A., Haack, K., Göring, H. H., Carless, M. A., Curran, J. E., Johnson, M. P., Almasy, L., Dyer, T. D., Maccluer, J. W., Moses, E. K., Abboud, H. E., Mahaney, M. C., Blangero, J., & Comuzzie, A. G. (2013). Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Frontiers in genetics, 4279. https://doi.org/10.3389/fgene.2013.00279
Voruganti, Venkata Saroja, et al. "Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans." Frontiers in genetics vol. 4 (2013): 279. doi: https://doi.org/10.3389/fgene.2013.00279
Voruganti VS, Kent JW, Debnath S, Cole SA, Haack K, Göring HH, Carless MA, Curran JE, Johnson MP, Almasy L, Dyer TD, Maccluer JW, Moses EK, Abboud HE, Mahaney MC, Blangero J, Comuzzie AG. Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Front Genet. 2013 Dec 16;4:279. doi: 10.3389/fgene.2013.00279. eCollection 2013. PMID: 24379826; PMCID: PMC3863993.
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Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes.

BMC proceedings

Peralta JM, Almasy L.
PMID: 18466503
BMC Proc. 2007;1:S158. doi: 10.1186/1753-6561-1-s1-s158. Epub 2007 Dec 18.

We compared results from linkage analyses of different phenotype measurements from the same gene expression traits and found that the strongest signals were detected by all expression measures that we considered. On average, that meant that the same quantitative...

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Peralta JM, Almasy L. Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes. BMC Proc. 2007;1:S158doi: 10.1186/1753-6561-1-s1-s158.
Peralta, J. M., & Almasy, L. (2007). Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes. BMC proceedings, 1S158. https://doi.org/10.1186/1753-6561-1-s1-s158
Peralta, Juan Manuel, and Almasy, Laura. "Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes." BMC proceedings vol. 1 (2007): S158. doi: https://doi.org/10.1186/1753-6561-1-s1-s158
Peralta JM, Almasy L. Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes. BMC Proc. 2007;1:S158. doi: 10.1186/1753-6561-1-s1-s158. Epub 2007 Dec 18. PMID: 18466503; PMCID: PMC2367575.
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P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

Frontiers in genetics

Kochunov P, Glahn DC, Hong LE, Lancaster J, Curran JE, Johnson MP, Winkler AM, Holcomb HH, Kent JW, Mitchell B, Kochunov V, Olvera RL, Cole SA, Dyer TD, Moses EK, Goring H, Almasy L, Duggirala R, Blangero J.
PMID: 22558002
Front Genet. 2012 May 01;3:65. doi: 10.3389/fgene.2012.00065. eCollection 2012.

BACKGROUND AND PURPOSE: We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene...

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Kochunov P, Glahn DC, Hong LE, et al. P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans. Front Genet. 2012;3:65doi: 10.3389/fgene.2012.00065.
Kochunov, P., Glahn, D. C., Hong, L. E., Lancaster, J., Curran, J. E., Johnson, M. P., Winkler, A. M., Holcomb, H. H., Kent, J. W., Mitchell, B., Kochunov, V., Olvera, R. L., Cole, S. A., Dyer, T. D., Moses, E. K., Goring, H., Almasy, L., Duggirala, R., & Blangero, J. (2012). P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans. Frontiers in genetics, 365. https://doi.org/10.3389/fgene.2012.00065
Kochunov, P, et al. "P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans." Frontiers in genetics vol. 3 (2012): 65. doi: https://doi.org/10.3389/fgene.2012.00065
Kochunov P, Glahn DC, Hong LE, Lancaster J, Curran JE, Johnson MP, Winkler AM, Holcomb HH, Kent JW, Mitchell B, Kochunov V, Olvera RL, Cole SA, Dyer TD, Moses EK, Goring H, Almasy L, Duggirala R, Blangero J. P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans. Front Genet. 2012 May 01;3:65. doi: 10.3389/fgene.2012.00065. eCollection 2012. PMID: 22558002; PMCID: PMC3340599.
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MM Algorithms for Geometric and Signomial Programming.

Mathematical programming

Lange K, Zhou H.
PMID: 24634545
Math Program. 2014 Feb 01;143(1):339-356. doi: 10.1007/s10107-012-0612-1.

This paper derives new algorithms for signomial programming, a generalization of geometric programming. The algorithms are based on a generic principle for optimization called the MM algorithm. In this setting, one can apply the geometric-arithmetic mean inequality and a...

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Lange K, Zhou H. MM Algorithms for Geometric and Signomial Programming. Math Program. 2014;143(1):339-356doi: 10.1007/s10107-012-0612-1.
Lange, K., & Zhou, H. (2014). MM Algorithms for Geometric and Signomial Programming. Mathematical programming, 143(1), 339-356. https://doi.org/10.1007/s10107-012-0612-1
Lange, Kenneth, and Zhou, Hua. "MM Algorithms for Geometric and Signomial Programming." Mathematical programming vol. 143,1 (2014): 339-356. doi: https://doi.org/10.1007/s10107-012-0612-1
Lange K, Zhou H. MM Algorithms for Geometric and Signomial Programming. Math Program. 2014 Feb 01;143(1):339-356. doi: 10.1007/s10107-012-0612-1. PMID: 24634545; PMCID: PMC3950732.
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Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test.

BMC proceedings

Peralta JM, Almeida M, Abraham LJ, Moses E, Blangero J.
PMID: 27980619
BMC Proc. 2016 Oct 18;10:103-108. doi: 10.1186/s12919-016-0013-1. eCollection 2016.

We present a novel approach to detect potential

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Peralta JM, Almeida M, Abraham LJ, et al. Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test. BMC Proc. 2016;10:103-108doi: 10.1186/s12919-016-0013-1.
Peralta, J. M., Almeida, M., Abraham, L. J., Moses, E., & Blangero, J. (2016). Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test. BMC proceedings, 10103-108. https://doi.org/10.1186/s12919-016-0013-1
Peralta, Juan Manuel, et al. "Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test." BMC proceedings vol. 10 (2016): 103-108. doi: https://doi.org/10.1186/s12919-016-0013-1
Peralta JM, Almeida M, Abraham LJ, Moses E, Blangero J. Finding potential cis-regulatory loci using allele-specific chromatin accessibility as weights in a kernel-based variance component test. BMC Proc. 2016 Oct 18;10:103-108. doi: 10.1186/s12919-016-0013-1. eCollection 2016. PMID: 27980619; PMCID: PMC5133489.
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Constrained multivariate association with longitudinal phenotypes.

BMC proceedings

Melton PE, Peralta JM, Almasy L.
PMID: 27980657
BMC Proc. 2016 Oct 18;10:329-332. doi: 10.1186/s12919-016-0051-8. eCollection 2016.

BACKGROUND: The incorporation of longitudinal data into genetic epidemiological studies has the potential to provide valuable information regarding the effect of time on complex disease etiology. Yet, the majority of research focuses on variables collected from a single time...

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Melton PE, Peralta JM, Almasy L. Constrained multivariate association with longitudinal phenotypes. BMC Proc. 2016;10:329-332doi: 10.1186/s12919-016-0051-8.
Melton, P. E., Peralta, J. M., & Almasy, L. (2016). Constrained multivariate association with longitudinal phenotypes. BMC proceedings, 10329-332. https://doi.org/10.1186/s12919-016-0051-8
Melton, Phillip E, et al. "Constrained multivariate association with longitudinal phenotypes." BMC proceedings vol. 10 (2016): 329-332. doi: https://doi.org/10.1186/s12919-016-0051-8
Melton PE, Peralta JM, Almasy L. Constrained multivariate association with longitudinal phenotypes. BMC Proc. 2016 Oct 18;10:329-332. doi: 10.1186/s12919-016-0051-8. eCollection 2016. PMID: 27980657; PMCID: PMC5133503.
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Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans.

Cerebral cortex (New York, N.Y. : 1991)

Mathias SR, Knowles EEM, Mollon J, Rodrigue A, Koenis MMC, Alexander-Bloch AF, Winkler AM, Olvera RL, Duggirala R, Göring HHH, Curran JE, Fox PT, Almasy L, Blangero J, Glahn DC.
PMID: 32037459
Cereb Cortex. 2020 May 18;30(6):3439-3450. doi: 10.1093/cercor/bhz319.

Previous studies suggest that gyrification is associated with superior cognitive abilities in humans, but the strength of this relationship remains unclear. Here, in two samples of related individuals (total N = 2882), we calculated an index of local gyrification...

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Mathias SR, Knowles EEM, Mollon J, et al. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cereb Cortex. 2020;30(6):3439-3450doi: 10.1093/cercor/bhz319.
Mathias, S. R., Knowles, E. E. M., Mollon, J., Rodrigue, A., Koenis, M. M. C., Alexander-Bloch, A. F., Winkler, A. M., Olvera, R. L., Duggirala, R., Göring, H. H. H., Curran, J. E., Fox, P. T., Almasy, L., Blangero, J., & Glahn, D. C. (2020). Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cerebral cortex (New York, N.Y. : 1991), 30(6), 3439-3450. https://doi.org/10.1093/cercor/bhz319
Mathias, Samuel R, et al. "Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans." Cerebral cortex (New York, N.Y. : 1991) vol. 30,6 (2020): 3439-3450. doi: https://doi.org/10.1093/cercor/bhz319
Mathias SR, Knowles EEM, Mollon J, Rodrigue A, Koenis MMC, Alexander-Bloch AF, Winkler AM, Olvera RL, Duggirala R, Göring HHH, Curran JE, Fox PT, Almasy L, Blangero J, Glahn DC. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cereb Cortex. 2020 May 18;30(6):3439-3450. doi: 10.1093/cercor/bhz319. PMID: 32037459; PMCID: PMC7233007.
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Independent test assessment using the extreme value distribution theory.

BMC proceedings

Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, Cingolani PE, Sladek R, Dyer TD, Abecasis G, Duggirala R, Blangero J.
PMID: 27980644
BMC Proc. 2016 Oct 18;10:245-249. doi: 10.1186/s12919-016-0038-5. eCollection 2016.

The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of...

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Almeida M, Blondell L, Peralta JM, et al. Independent test assessment using the extreme value distribution theory. BMC Proc. 2016;10:245-249doi: 10.1186/s12919-016-0038-5.
Almeida, M., Blondell, L., Peralta, J. M., Kent, J. W., Jun, G., Teslovich, T. M., Fuchsberger, C., Wood, A. R., Manning, A. K., Frayling, T. M., Cingolani, P. E., Sladek, R., Dyer, T. D., Abecasis, G., Duggirala, R., & Blangero, J. (2016). Independent test assessment using the extreme value distribution theory. BMC proceedings, 10245-249. https://doi.org/10.1186/s12919-016-0038-5
Almeida, Marcio, et al. "Independent test assessment using the extreme value distribution theory." BMC proceedings vol. 10 (2016): 245-249. doi: https://doi.org/10.1186/s12919-016-0038-5
Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, Cingolani PE, Sladek R, Dyer TD, Abecasis G, Duggirala R, Blangero J. Independent test assessment using the extreme value distribution theory. BMC Proc. 2016 Oct 18;10:245-249. doi: 10.1186/s12919-016-0038-5. eCollection 2016. PMID: 27980644; PMCID: PMC5133519.
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A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study.

International journal of vascular medicine

Diego VP, Almasy L, Rainwater DL, Mahaney MC, Comuzzie AG, Cole SA, Tracy RP, Stern MP, Maccluer JW, Blangero J.
PMID: 21151504
Int J Vasc Med. 2010;2010:490241. doi: 10.1155/2010/490241. Epub 2010 Jun 27.

Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females)...

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Diego VP, Almasy L, Rainwater DL, et al. A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study. Int J Vasc Med. 2010;2010:490241doi: 10.1155/2010/490241.
Diego, V. P., Almasy, L., Rainwater, D. L., Mahaney, M. C., Comuzzie, A. G., Cole, S. A., Tracy, R. P., Stern, M. P., Maccluer, J. W., & Blangero, J. (2010). A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study. International journal of vascular medicine, 2010490241. https://doi.org/10.1155/2010/490241
Diego, V P, et al. "A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study." International journal of vascular medicine vol. 2010 (2010): 490241. doi: https://doi.org/10.1155/2010/490241
Diego VP, Almasy L, Rainwater DL, Mahaney MC, Comuzzie AG, Cole SA, Tracy RP, Stern MP, Maccluer JW, Blangero J. A quantitative trait locus on chromosome 5p influences d-dimer levels in the san antonio family heart study. Int J Vasc Med. 2010;2010:490241. doi: 10.1155/2010/490241. Epub 2010 Jun 27. PMID: 21151504; PMCID: PMC2989697.
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Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays.

Journal of the American Statistical Association

Sabatti C, Lange K.
PMID: 21572926
J Am Stat Assoc. 2008 Mar 01;103(481):89-100. doi: 10.1198/016214507000000338..

Affymetrix's SNP (single-nucleotide polymorphism) genotyping chips have increased the scope and decreased the cost of gene-mapping studies. Because each SNP is queried by multiple DNA probes, the chips present interesting challenges in genotype calling. Traditional clustering methods distinguish the...

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Sabatti C, Lange K. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. J Am Stat Assoc. 2008;103(481):89-100doi: 10.1198/016214507000000338..
Sabatti, C., & Lange, K. (2008). Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. Journal of the American Statistical Association, 103(481), 89-100. https://doi.org/10.1198/016214507000000338.
Sabatti, Chiara, and Lange, Kenneth. "Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays." Journal of the American Statistical Association vol. 103,481 (2008): 89-100. doi: https://doi.org/10.1198/016214507000000338.
Sabatti C, Lange K. Bayesian Gaussian Mixture Models for High-Density Genotyping Arrays. J Am Stat Assoc. 2008 Mar 01;103(481):89-100. doi: 10.1198/016214507000000338.. PMID: 21572926; PMCID: PMC3092390.
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Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in .

Circulation. Genomic and precision medicine

Blackburn NB, Meikle PJ, Peralta JM, Kumar S, Leandro AC, Bellinger MA, Giles C, Huynh K, Mahaney MC, Göring HHH, VandeBerg JL, Williams-Blangero S, Glahn DC, Duggirala R, Blangero J, Michael LF, Curran JE.
PMID: 33887960
Circ Genom Precis Med. 2021 Jun;14(3):e003232. doi: 10.1161/CIRCGEN.120.003232. Epub 2021 Apr 22.

BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundamental importance given its global health and economic burden. Inhibition of ANGPTL3 (angiopoietin-like 3) has demonstrated a cardioprotective effect, showing promise for atherosclerotic cardiovascular disease...

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Blackburn NB, Meikle PJ, Peralta JM, et al. Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in . Circ Genom Precis Med. 2021;14(3):e003232doi: 10.1161/CIRCGEN.120.003232.
Blackburn, N. B., Meikle, P. J., Peralta, J. M., Kumar, S., Leandro, A. C., Bellinger, M. A., Giles, C., Huynh, K., Mahaney, M. C., Göring, H. H. H., VandeBerg, J. L., Williams-Blangero, S., Glahn, D. C., Duggirala, R., Blangero, J., Michael, L. F., & Curran, J. E. (2021). Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in . Circulation. Genomic and precision medicine, 14(3), e003232. https://doi.org/10.1161/CIRCGEN.120.003232
Blackburn, Nicholas B, et al. "Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ." Circulation. Genomic and precision medicine vol. 14,3 (2021): e003232. doi: https://doi.org/10.1161/CIRCGEN.120.003232
Blackburn NB, Meikle PJ, Peralta JM, Kumar S, Leandro AC, Bellinger MA, Giles C, Huynh K, Mahaney MC, Göring HHH, VandeBerg JL, Williams-Blangero S, Glahn DC, Duggirala R, Blangero J, Michael LF, Curran JE. Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in . Circ Genom Precis Med. 2021 Jun;14(3):e003232. doi: 10.1161/CIRCGEN.120.003232. Epub 2021 Apr 22. PMID: 33887960; PMCID: PMC8206021.
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An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome.

Clinical epigenetics

Ali O, Cerjak D, Kent JW, James R, Blangero J, Carless MA, Zhang Y.
PMID: 25806089
Clin Epigenetics. 2015 Feb 20;7:12. doi: 10.1186/s13148-015-0048-6. eCollection 2015.

BACKGROUND: The prevalence of chronic diseases such as cancer, type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease increases with age in all populations. Epigenetic features are hypothesized to play important roles in the pathophysiology of age-associated diseases, but...

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Ali O, Cerjak D, Kent JW, et al. An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome. Clin Epigenetics. 2015;7:12doi: 10.1186/s13148-015-0048-6.
Ali, O., Cerjak, D., Kent, J. W., James, R., Blangero, J., Carless, M. A., & Zhang, Y. (2015). An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome. Clinical epigenetics, 712. https://doi.org/10.1186/s13148-015-0048-6
Ali, Omar, et al. "An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome." Clinical epigenetics vol. 7 (2015): 12. doi: https://doi.org/10.1186/s13148-015-0048-6
Ali O, Cerjak D, Kent JW, James R, Blangero J, Carless MA, Zhang Y. An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome. Clin Epigenetics. 2015 Feb 20;7:12. doi: 10.1186/s13148-015-0048-6. eCollection 2015. PMID: 25806089; PMCID: PMC4372177.
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Showing 1 to 12 of 21 entries