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Showing 1 to 8 of 8 entries
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8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation.

International journal of physiology, pathophysiology and pharmacology

Liu Q, Rehman H, Krishnasamy Y, Lemasters JJ, Zhong Z.
PMID: 28694919
Int J Physiol Pathophysiol Pharmacol. 2017 Jun 15;9(3):69-83. eCollection 2017.

Permeant cGMP analogs prevent the mitochondria permeability transition (MPT)

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Liu Q, Rehman H, Krishnasamy Y, et al. 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol. 2017;9(3):69-83
Liu, Q., Rehman, H., Krishnasamy, Y., Lemasters, J. J., & Zhong, Z. (2017). 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. International journal of physiology, pathophysiology and pharmacology, 9(3), 69-83.
Liu, Qinlong, et al. "8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation." International journal of physiology, pathophysiology and pharmacology vol. 9,3 (2017): 69-83.
Liu Q, Rehman H, Krishnasamy Y, Lemasters JJ, Zhong Z. 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol. 2017 Jun 15;9(3):69-83. eCollection 2017. PMID: 28694919; PMCID: PMC5498880.
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Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Currin RT, Peng XX, Lemasters JJ.
PMID: 22888183
HPB Surg. 2012;2012:236406. doi: 10.1155/2012/236406. Epub 2012 Jul 19.

A critical shortage of donors exists for liver transplantation, which non-heart-beating cadaver donors could help ease. This study evaluated ischemic preconditioning to improve graft viability after non-heart-beating liver donation in rats. Ischemic preconditioning was performed by clamping the portal...

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Currin RT, Peng XX, Lemasters JJ. Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation. HPB Surg. 2012;2012:236406doi: 10.1155/2012/236406.
Currin, R. T., Peng, X. X., & Lemasters, J. J. (2012). Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012236406. https://doi.org/10.1155/2012/236406
Currin, Robert T, et al. "Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2012 (2012): 236406. doi: https://doi.org/10.1155/2012/236406
Currin RT, Peng XX, Lemasters JJ. Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation. HPB Surg. 2012;2012:236406. doi: 10.1155/2012/236406. Epub 2012 Jul 19. PMID: 22888183; PMCID: PMC3408666.
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C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, Lemasters JJ.
PMID: 22791932
HPB Surg. 2012;2012:641982. doi: 10.1155/2012/641982. Epub 2012 Jun 27.

Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis after hemorrhage/resuscitation (H/R) was...

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Czerny C, Theruvath TP, Maldonado EN, et al. C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB Surg. 2012;2012:641982doi: 10.1155/2012/641982.
Czerny, C., Theruvath, T. P., Maldonado, E. N., Lehnert, M., Marzi, I., Zhong, Z., & Lemasters, J. J. (2012). C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012641982. https://doi.org/10.1155/2012/641982
Czerny, Christoph, et al. "C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2012 (2012): 641982. doi: https://doi.org/10.1155/2012/641982
Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB Surg. 2012;2012:641982. doi: 10.1155/2012/641982. Epub 2012 Jun 27. PMID: 22791932; PMCID: PMC3390051.
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Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Theruvath TP, Ramshesh VK, Zhong Z, Currin RT, Karrasch T, Lemasters JJ.
PMID: 22778492
HPB Surg. 2012;2012:480893. doi: 10.1155/2012/480893. Epub 2012 Jun 18.

Background. Transplantation of ethanol-induced steatotic livers causes increased graft injury. We hypothesized that upregulation of hepatic ICAM-1 after ethanol produces increased leukocyte adherence, resulting in increased generation of reactive oxygen species (ROS) and injury after liver transplantation (LT). Methods....

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Theruvath TP, Ramshesh VK, Zhong Z, et al. Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation. HPB Surg. 2012;2012:480893doi: 10.1155/2012/480893.
Theruvath, T. P., Ramshesh, V. K., Zhong, Z., Currin, R. T., Karrasch, T., & Lemasters, J. J. (2012). Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012480893. https://doi.org/10.1155/2012/480893
Theruvath, Tom P, et al. "Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2012 (2012): 480893. doi: https://doi.org/10.1155/2012/480893
Theruvath TP, Ramshesh VK, Zhong Z, Currin RT, Karrasch T, Lemasters JJ. Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation. HPB Surg. 2012;2012:480893. doi: 10.1155/2012/480893. Epub 2012 Jun 18. PMID: 22778492; PMCID: PMC3385666.
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The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice.

International journal of physiology, pathophysiology and pharmacology

Rehman H, Liu Q, Krishnasamy Y, Shi Z, Ramshesh VK, Haque K, Schnellmann RG, Murphy MP, Lemasters JJ, Rockey DC, Zhong Z.
PMID: 27186319
Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):14-27. eCollection 2016.

Oxidative stress plays an essential role in liver fibrosis. This study investigated whether MitoQ, an orally active mitochondrial antioxidant, decreases liver fibrosis. Mice were injected with corn oil or carbon tetrachloride (CCl4, 1:3 dilution in corn oil; 1 µl/g,...

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Rehman H, Liu Q, Krishnasamy Y, et al. The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice. Int J Physiol Pathophysiol Pharmacol. 2016;8(1):14-27
Rehman, H., Liu, Q., Krishnasamy, Y., Shi, Z., Ramshesh, V. K., Haque, K., Schnellmann, R. G., Murphy, M. P., Lemasters, J. J., Rockey, D. C., & Zhong, Z. (2016). The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice. International journal of physiology, pathophysiology and pharmacology, 8(1), 14-27.
Rehman, Hasibur, et al. "The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice." International journal of physiology, pathophysiology and pharmacology vol. 8,1 (2016): 14-27.
Rehman H, Liu Q, Krishnasamy Y, Shi Z, Ramshesh VK, Haque K, Schnellmann RG, Murphy MP, Lemasters JJ, Rockey DC, Zhong Z. The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice. Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):14-27. eCollection 2016. PMID: 27186319; PMCID: PMC4859875.
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Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice.

PloS one

Krishnasamy Y, Ramshesh VK, Gooz M, Schnellmann RG, Lemasters JJ, Zhong Z.
PMID: 27676640
PLoS One. 2016 Sep 27;11(9):e0163342. doi: 10.1371/journal.pone.0163342. eCollection 2016.

BACKGROUND AND AIM: Because ethanol consumption is commonly associated with a high cholesterol diet, we examined whether combined consumption of ethanol and high cholesterol increases liver injury and fibrosis.METHODS: Male C57BL/6J mice were fed diets containing: 1) 35% of...

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Krishnasamy Y, Ramshesh VK, Gooz M, et al. Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice. PLoS One. 2016;11(9):e0163342doi: 10.1371/journal.pone.0163342.
Krishnasamy, Y., Ramshesh, V. K., Gooz, M., Schnellmann, R. G., Lemasters, J. J., & Zhong, Z. (2016). Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice. PloS one, 11(9), e0163342. https://doi.org/10.1371/journal.pone.0163342
Krishnasamy, Yasodha, et al. "Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice." PloS one vol. 11,9 (2016): e0163342. doi: https://doi.org/10.1371/journal.pone.0163342
Krishnasamy Y, Ramshesh VK, Gooz M, Schnellmann RG, Lemasters JJ, Zhong Z. Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice. PLoS One. 2016 Sep 27;11(9):e0163342. doi: 10.1371/journal.pone.0163342. eCollection 2016. PMID: 27676640; PMCID: PMC5038945.
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Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Liu Q, Rehman H, Harley RA, Lemasters JJ, Zhong Z.
PMID: 22675237
HPB Surg. 2012;2012:270372. doi: 10.1155/2012/270372. Epub 2012 May 22.

Pulmonary complications after liver transplantation (LT) often cause mortality. This study investigated whether small-for-size LT increases acute pulmonary injury and whether NIM811 which improves small-for-size liver graft survival attenuates LT-associated lung injury. Rat livers were reduced to 50% of...

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Liu Q, Rehman H, Harley RA, et al. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811. HPB Surg. 2012;2012:270372doi: 10.1155/2012/270372.
Liu, Q., Rehman, H., Harley, R. A., Lemasters, J. J., & Zhong, Z. (2012). Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012270372. https://doi.org/10.1155/2012/270372
Liu, Qinlong, et al. "Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2012 (2012): 270372. doi: https://doi.org/10.1155/2012/270372
Liu Q, Rehman H, Harley RA, Lemasters JJ, Zhong Z. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811. HPB Surg. 2012;2012:270372. doi: 10.1155/2012/270372. Epub 2012 May 22. PMID: 22675237; PMCID: PMC3364580.
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Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ.
PMID: 22719175
HPB Surg. 2012;2012:259512. doi: 10.1155/2012/259512. Epub 2012 Jun 07.

Patients that survive hemorrhage and resuscitation (H/R) may develop a systemic inflammatory response syndrome (SIRS) that leads to dysfunction of vital organs (multiple organ dysfunction syndrome, MODS). SIRS and MODS may involve mitochondrial dysfunction. Under pentobarbital anesthesia, C57BL6 mice...

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Czerny C, Kholmukhamedov A, Theruvath TP, et al. Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB Surg. 2012;2012:259512doi: 10.1155/2012/259512.
Czerny, C., Kholmukhamedov, A., Theruvath, T. P., Maldonado, E. N., Ramshesh, V. K., Lehnert, M., Marzi, I., Zhong, Z., & Lemasters, J. J. (2012). Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2012259512. https://doi.org/10.1155/2012/259512
Czerny, Christoph, et al. "Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2012 (2012): 259512. doi: https://doi.org/10.1155/2012/259512
Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB Surg. 2012;2012:259512. doi: 10.1155/2012/259512. Epub 2012 Jun 07. PMID: 22719175; PMCID: PMC3375163.
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Showing 1 to 8 of 8 entries