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Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Diabetologia

Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM.
PMID: 34951656
Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24.

AIMS/HYPOTHESIS: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbAMETHODS: We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbARESULTS: Four...

Cite
Downie CG, Dimos SF, Bien SA, et al. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021;doi: 10.1007/s00125-021-05635-9.
Downie, C. G., Dimos, S. F., Bien, S. A., Hu, Y., Darst, B. F., Polfus, L. M., Wang, Y., Wojcik, G. L., Tao, R., Raffield, L. M., Armstrong, N. D., Polikowsky, H. G., Below, J. E., Correa, A., Irvin, M. R., Rasmussen-Torvik, L. J. F., Carlson, C. S., Phillips, L. S., Liu, S., Pankow, J. S., Rich, S. S., Rotter, J. I., Buyske, S., Matise, T. C., North, K. E., Avery, C. L., Haiman, C. A., Loos, R. J. F., Kooperberg, C., Graff, M., & Highland, H. M. (2021). Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia, . https://doi.org/10.1007/s00125-021-05635-9
Downie, Carolina G, et al. "Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study." Diabetologia vol. (2021). doi: https://doi.org/10.1007/s00125-021-05635-9
Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24. PMID: 34951656.
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Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Diabetologia

Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM.
PMID: 34951656
Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24.

AIMS/HYPOTHESIS: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbAMETHODS: We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbARESULTS: Four...

Cite
Downie CG, Dimos SF, Bien SA, et al. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021;doi: 10.1007/s00125-021-05635-9.
Downie, C. G., Dimos, S. F., Bien, S. A., Hu, Y., Darst, B. F., Polfus, L. M., Wang, Y., Wojcik, G. L., Tao, R., Raffield, L. M., Armstrong, N. D., Polikowsky, H. G., Below, J. E., Correa, A., Irvin, M. R., Rasmussen-Torvik, L. J. F., Carlson, C. S., Phillips, L. S., Liu, S., Pankow, J. S., Rich, S. S., Rotter, J. I., Buyske, S., Matise, T. C., North, K. E., Avery, C. L., Haiman, C. A., Loos, R. J. F., Kooperberg, C., Graff, M., & Highland, H. M. (2021). Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia, . https://doi.org/10.1007/s00125-021-05635-9
Downie, Carolina G, et al. "Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study." Diabetologia vol. (2021). doi: https://doi.org/10.1007/s00125-021-05635-9
Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24. PMID: 34951656.
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Genetic discovery and risk characterization in type 2 diabetes across diverse populations.

HGG advances

Polfus LM, Darst BF, Highland H, Sheng X, Ng MCY, Below JE, Petty L, Bien S, Sim X, Wang W, Fontanillas P, Patel Y, Preuss M, Schurmann C, Du Z, Lu Y, Rhie SK, Mercader JM, Tusie-Luna T, González-Villalpando C, Orozco L, Spracklen CN, Cade BE, Jensen RA, Sun M, Joo YY, An P, Yanek LR, Bielak LF, Tajuddin S, Nicolas A, Chen G, Raffield L, Guo X, Chen WM, Nadkarni GN, Graff M, Tao R, Pankow JS, Daviglus M, Qi Q, Boerwinkle EA, Liu S, Phillips LS, Peters U, Carlson C, Wikens LR, Marchand LL, North KE, Buyske S, Kooperberg C, Loos RJF, Stram DO, Haiman CA.
PMID: 34604815
HGG Adv. 2021 Apr 08;2(2). doi: 10.1016/j.xhgg.2021.100029. Epub 2021 Mar 09.

Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African,...

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Polfus LM, Darst BF, Highland H, et al. Genetic discovery and risk characterization in type 2 diabetes across diverse populations. HGG Adv. 2021;2(2)doi: 10.1016/j.xhgg.2021.100029.
Polfus, L. M., Darst, B. F., Highland, H., Sheng, X., Ng, M. C. Y., Below, J. E., Petty, L., Bien, S., Sim, X., Wang, W., Fontanillas, P., Patel, Y., Preuss, M., Schurmann, C., Du, Z., Lu, Y., Rhie, S. K., Mercader, J. M., Tusie-Luna, T., González-Villalpando, C., Orozco, L., Spracklen, C. N., Cade, B. E., Jensen, R. A., Sun, M., Joo, Y. Y., An, P., Yanek, L. R., Bielak, L. F., Tajuddin, S., Nicolas, A., Chen, G., Raffield, L., Guo, X., Chen, W. M., Nadkarni, G. N., Graff, M., Tao, R., Pankow, J. S., Daviglus, M., Qi, Q., Boerwinkle, E. A., Liu, S., Phillips, L. S., Peters, U., Carlson, C., Wikens, L. R., Marchand, L. L., North, K. E., Buyske, S., Kooperberg, C., Loos, R. J. F., Stram, D. O., & Haiman, C. A. (2021). Genetic discovery and risk characterization in type 2 diabetes across diverse populations. HGG advances, 2(2), . https://doi.org/10.1016/j.xhgg.2021.100029
Polfus, Linda M, et al. "Genetic discovery and risk characterization in type 2 diabetes across diverse populations." HGG advances vol. 2,2 (2021). doi: https://doi.org/10.1016/j.xhgg.2021.100029
Polfus LM, Darst BF, Highland H, Sheng X, Ng MCY, Below JE, Petty L, Bien S, Sim X, Wang W, Fontanillas P, Patel Y, Preuss M, Schurmann C, Du Z, Lu Y, Rhie SK, Mercader JM, Tusie-Luna T, González-Villalpando C, Orozco L, Spracklen CN, Cade BE, Jensen RA, Sun M, Joo YY, An P, Yanek LR, Bielak LF, Tajuddin S, Nicolas A, Chen G, Raffield L, Guo X, Chen WM, Nadkarni GN, Graff M, Tao R, Pankow JS, Daviglus M, Qi Q, Boerwinkle EA, Liu S, Phillips LS, Peters U, Carlson C, Wikens LR, Marchand LL, North KE, Buyske S, Kooperberg C, Loos RJF, Stram DO, Haiman CA. Genetic discovery and risk characterization in type 2 diabetes across diverse populations. HGG Adv. 2021 Apr 08;2(2). doi: 10.1016/j.xhgg.2021.100029. Epub 2021 Mar 09. PMID: 34604815; PMCID: PMC8486151.
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Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos.

BMC obesity

Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE.
PMID: 30305909
BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018.

BACKGROUND: Genome-wide association studies have implicated the METHODS: Using 9031 Hispanic/Latino adults (21-76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008-2011), we estimated the multivariable association between...

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Fernández-Rhodes L, Howard AG, Graff M, et al. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018;5:26doi: 10.1186/s40608-018-0200-x.
Fernández-Rhodes, L., Howard, A. G., Graff, M., Isasi, C. R., Highland, H. M., Young, K. L., Parra, E., Below, J. E., Qi, Q., Kaplan, R. C., Justice, A. E., Papanicolaou, G., Laurie, C. C., Grant, S. F. A., Haiman, C., Loos, R. J. F., & North, K. E. (2018). Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC obesity, 526. https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes, Lindsay, et al. "Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos." BMC obesity vol. 5 (2018): 26. doi: https://doi.org/10.1186/s40608-018-0200-x
Fernández-Rhodes L, Howard AG, Graff M, Isasi CR, Highland HM, Young KL, Parra E, Below JE, Qi Q, Kaplan RC, Justice AE, Papanicolaou G, Laurie CC, Grant SFA, Haiman C, Loos RJF, North KE. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos. BMC Obes. 2018 Oct 02;5:26. doi: 10.1186/s40608-018-0200-x. eCollection 2018. PMID: 30305909; PMCID: PMC6167893.
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Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents.

Pediatric research

Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE.
PMID: 34645953
Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13.

BACKGROUND: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers-adiponectin, leptin, ghrelin, and orexin-and...

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Kim D, Justice AE, Chittoor G, et al. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021;doi: 10.1038/s41390-021-01729-7.
Kim, D., Justice, A. E., Chittoor, G., Blanco, E., Burrows, R., Graff, M., Howard, A. G., Wang, Y., Rohde, R., Buchanan, V. L., Voruganti, V. S., Almeida, M., Peralta, J., Lehman, D. M., Curran, J. E., Comuzzie, A. G., Duggirala, R., Blangero, J., Albala, C., Santos, J. L., Angel, B., Lozoff, B., Gahagan, S., & North, K. E. (2021). Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatric research, . https://doi.org/10.1038/s41390-021-01729-7
Kim, Daeeun, et al. "Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents." Pediatric research vol. (2021). doi: https://doi.org/10.1038/s41390-021-01729-7
Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13. PMID: 34645953.
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