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Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease.

Annals of clinical and translational neurology

Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, Vardarajan BN, Goldstein DB, Mayeux R.
PMID: 30009200
Ann Clin Transl Neurol. 2018 May 24;5(7):832-842. doi: 10.1002/acn3.582. eCollection 2018 Jul.

OBJECTIVE: The genetic bases of Alzheimer's disease remain uncertain. An international effort to fully articulate genetic risks and protective factors is underway with the hope of identifying potential therapeutic targets and preventive strategies. The goal here was to identify...

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Raghavan NS, Brickman AM, Andrews H, et al. Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol. 2018;5(7):832-842doi: 10.1002/acn3.582.
Raghavan, N. S., Brickman, A. M., Andrews, H., Manly, J. J., Schupf, N., Lantigua, R., Wolock, C. J., Kamalakaran, S., Petrovski, S., Tosto, G., Vardarajan, B. N., Goldstein, D. B., Mayeux, R. (2018). Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Annals of clinical and translational neurology, 5(7), 832-842. https://doi.org/10.1002/acn3.582
Raghavan, Neha S, et al. "Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease." Annals of clinical and translational neurology vol. 5,7 (2018): 832-842. doi: https://doi.org/10.1002/acn3.582
Raghavan NS, Brickman AM, Andrews H, Manly JJ, Schupf N, Lantigua R, Wolock CJ, Kamalakaran S, Petrovski S, Tosto G, Vardarajan BN, Goldstein DB, Mayeux R. Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol. 2018 May 24;5(7):832-842. doi: 10.1002/acn3.582. eCollection 2018 Jul. PMID: 30009200; PMCID: PMC6043775.
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Reproducibility of serum cytokines in an elderly population.

Immunity & ageing : I & A

Guo J, Schupf N, Mayeux RP, Gu Y.
PMID: 33072162
Immun Ageing. 2020 Oct 13;17:29. doi: 10.1186/s12979-020-00201-0. eCollection 2020.

BACKGROUND: It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly population.METHODS: Sixty-five elderly (mean age = 77.89 ± 6.14 years)...

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Guo J, Schupf N, Mayeux RP, et al. Reproducibility of serum cytokines in an elderly population. Immun Ageing. 2020;17:29doi: 10.1186/s12979-020-00201-0.
Guo, J., Schupf, N., Mayeux, R. P., & Gu, Y. (2020). Reproducibility of serum cytokines in an elderly population. Immunity & ageing : I & A, 1729. https://doi.org/10.1186/s12979-020-00201-0
Guo, Jing, et al. "Reproducibility of serum cytokines in an elderly population." Immunity & ageing : I & A vol. 17 (2020): 29. doi: https://doi.org/10.1186/s12979-020-00201-0
Guo J, Schupf N, Mayeux RP, Gu Y. Reproducibility of serum cytokines in an elderly population. Immun Ageing. 2020 Oct 13;17:29. doi: 10.1186/s12979-020-00201-0. eCollection 2020. PMID: 33072162; PMCID: PMC7556943.
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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y.
PMID: 33938146
Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02.

INTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.METHODS: Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status....

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Guo J, Brickman AM, Manly JJ, et al. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021;17(12):1905-1913doi: 10.1002/alz.12359.
Guo, J., Brickman, A. M., Manly, J. J., Reitz, C., Schupf, N., Mayeux, R. P., & Gu, Y. (2021). Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1905-1913. https://doi.org/10.1002/alz.12359
Guo, Jing, et al. "Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,12 (2021): 1905-1913. doi: https://doi.org/10.1002/alz.12359
Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02. PMID: 33938146; PMCID: PMC8560654.
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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y.
PMID: 33938146
Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02.

INTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.METHODS: Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status....

Cite
Guo J, Brickman AM, Manly JJ, et al. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021;17(12):1905-1913doi: 10.1002/alz.12359.
Guo, J., Brickman, A. M., Manly, J. J., Reitz, C., Schupf, N., Mayeux, R. P., & Gu, Y. (2021). Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1905-1913. https://doi.org/10.1002/alz.12359
Guo, Jing, et al. "Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,12 (2021): 1905-1913. doi: https://doi.org/10.1002/alz.12359
Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02. PMID: 33938146; PMCID: PMC8560654.
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Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease.

JAMA neurology

Tosto G, Vardarajan B, Sariya S, Brickman AM, Andrews H, Manly JJ, Schupf N, Reyes-Dumeyer D, Lantigua R, Bennett DA, De Jager PL, Mayeux R.
PMID: 31058951
JAMA Neurol. 2019 Aug 01;76(8):942-948. doi: 10.1001/jamaneurol.2019.1066.

IMPORTANCE: Genetic causes of late-onset Alzheimer disease (LOAD) are not completely explained by known genetic loci. Whole-exome and whole-genome sequencing can improve the understanding of the causes of LOAD and provide initial steps required to identify potential therapeutic targets.OBJECTIVE:...

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Tosto G, Vardarajan B, Sariya S, et al. Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease. JAMA Neurol. 2019;76(8):942-948doi: 10.1001/jamaneurol.2019.1066.
Tosto, G., Vardarajan, B., Sariya, S., Brickman, A. M., Andrews, H., Manly, J. J., Schupf, N., Reyes-Dumeyer, D., Lantigua, R., Bennett, D. A., De Jager, P. L., & Mayeux, R. (2019). Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease. JAMA neurology, 76(8), 942-948. https://doi.org/10.1001/jamaneurol.2019.1066
Tosto, Giuseppe, et al. "Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease." JAMA neurology vol. 76,8 (2019): 942-948. doi: https://doi.org/10.1001/jamaneurol.2019.1066
Tosto G, Vardarajan B, Sariya S, Brickman AM, Andrews H, Manly JJ, Schupf N, Reyes-Dumeyer D, Lantigua R, Bennett DA, De Jager PL, Mayeux R. Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease. JAMA Neurol. 2019 Aug 01;76(8):942-948. doi: 10.1001/jamaneurol.2019.1066. PMID: 31058951; PMCID: PMC6503572.
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Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities.

Neurology. Genetics

Beecham A, Dong C, Wright CB, Dueker N, Brickman AM, Wang L, DeCarli C, Blanton SH, Rundek T, Mayeux R, Sacco RL.
PMID: 28975155
Neurol Genet. 2017 Sep 25;3(5):e185. doi: 10.1212/NXG.0000000000000185. eCollection 2017 Oct.

OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population.METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922...

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Beecham A, Dong C, Wright CB, et al. Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurol Genet. 2017;3(5):e185doi: 10.1212/NXG.0000000000000185.
Beecham, A., Dong, C., Wright, C. B., Dueker, N., Brickman, A. M., Wang, L., DeCarli, C., Blanton, S. H., Rundek, T., Mayeux, R., & Sacco, R. L. (2017). Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurology. Genetics, 3(5), e185. https://doi.org/10.1212/NXG.0000000000000185
Beecham, Ashley, et al. "Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities." Neurology. Genetics vol. 3,5 (2017): e185. doi: https://doi.org/10.1212/NXG.0000000000000185
Beecham A, Dong C, Wright CB, Dueker N, Brickman AM, Wang L, DeCarli C, Blanton SH, Rundek T, Mayeux R, Sacco RL. Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities. Neurol Genet. 2017 Sep 25;3(5):e185. doi: 10.1212/NXG.0000000000000185. eCollection 2017 Oct. PMID: 28975155; PMCID: PMC5619914.
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Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools.

Frontiers in genetics

Sariya S, Lee JH, Mayeux R, Vardarajan BN, Reyes-Dumeyer D, Manly JJ, Brickman AM, Lantigua R, Medrano M, Jimenez-Velazquez IZ, Tosto G.
PMID: 31001313
Front Genet. 2019 Apr 03;10:239. doi: 10.3389/fgene.2019.00239. eCollection 2019.

BACKGROUND: Imputation has become a standard approach in genome-wide association studies (GWAS) to infer METHODS: We evaluated imputation accuracy in CH (RESULTS: SHAPEIT2 retrieved higher percentage of imputed high-quality variants than Eagle2 (rare: 51.02% vs. 48.60%; ultra-rare 0.66% vs....

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Sariya S, Lee JH, Mayeux R, et al. Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools. Front Genet. 2019;10:239doi: 10.3389/fgene.2019.00239.
Sariya, S., Lee, J. H., Mayeux, R., Vardarajan, B. N., Reyes-Dumeyer, D., Manly, J. J., Brickman, A. M., Lantigua, R., Medrano, M., Jimenez-Velazquez, I. Z., & Tosto, G. (2019). Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools. Frontiers in genetics, 10239. https://doi.org/10.3389/fgene.2019.00239
Sariya, Sanjeev, et al. "Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools." Frontiers in genetics vol. 10 (2019): 239. doi: https://doi.org/10.3389/fgene.2019.00239
Sariya S, Lee JH, Mayeux R, Vardarajan BN, Reyes-Dumeyer D, Manly JJ, Brickman AM, Lantigua R, Medrano M, Jimenez-Velazquez IZ, Tosto G. Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools. Front Genet. 2019 Apr 03;10:239. doi: 10.3389/fgene.2019.00239. eCollection 2019. PMID: 31001313; PMCID: PMC6456789.
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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y.
PMID: 33938146
Alzheimers Dement. 2021 May 02; doi: 10.1002/alz.12359. Epub 2021 May 02.

INTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.METHODS: Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status....

Cite
Guo J, Brickman AM, Manly JJ, et al. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021;doi: 10.1002/alz.12359.
Guo, J., Brickman, A. M., Manly, J. J., Reitz, C., Schupf, N., Mayeux, R. P., & Gu, Y. (2021). Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12359
Guo, Jing, et al. "Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12359
Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021 May 02; doi: 10.1002/alz.12359. Epub 2021 May 02. PMID: 33938146; PMCID: PMC8560654.
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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y.
PMID: 33938146
Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02.

INTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population.METHODS: Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status....

Cite
Guo J, Brickman AM, Manly JJ, et al. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021;17(12):1905-1913doi: 10.1002/alz.12359.
Guo, J., Brickman, A. M., Manly, J. J., Reitz, C., Schupf, N., Mayeux, R. P., & Gu, Y. (2021). Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(12), 1905-1913. https://doi.org/10.1002/alz.12359
Guo, Jing, et al. "Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,12 (2021): 1905-1913. doi: https://doi.org/10.1002/alz.12359
Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y. Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype. Alzheimers Dement. 2021 Dec;17(12):1905-1913. doi: 10.1002/alz.12359. Epub 2021 May 02. PMID: 33938146; PMCID: PMC8560654.
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Patterns of tau pathology identified with .

Alzheimer's & dementia : the journal of the Alzheimer's Association

Kreisl WC, Lao PJ, Johnson A, Tomljanovic Z, Klein J, Polly K, Maas B, Laing KK, Chesebro AG, Igwe K, Razlighi QR, Honig LS, Yan X, Lee S, Mintz A, Luchsinger JA, Stern Y, Devanand DP, Brickman AM.
PMID: 34057284
Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12384. Epub 2021 May 31.

No abstract available.

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Kreisl WC, Lao PJ, Johnson A, et al. Patterns of tau pathology identified with . Alzheimers Dement. 2021;doi: 10.1002/alz.12384.
Kreisl, W. C., Lao, P. J., Johnson, A., Tomljanovic, Z., Klein, J., Polly, K., Maas, B., Laing, K. K., Chesebro, A. G., Igwe, K., Razlighi, Q. R., Honig, L. S., Yan, X., Lee, S., Mintz, A., Luchsinger, J. A., Stern, Y., Devanand, D. P., & Brickman, A. M. (2021). Patterns of tau pathology identified with . Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12384
Kreisl, William Charles, et al. "Patterns of tau pathology identified with ." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12384
Kreisl WC, Lao PJ, Johnson A, Tomljanovic Z, Klein J, Polly K, Maas B, Laing KK, Chesebro AG, Igwe K, Razlighi QR, Honig LS, Yan X, Lee S, Mintz A, Luchsinger JA, Stern Y, Devanand DP, Brickman AM. Patterns of tau pathology identified with . Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12384. Epub 2021 May 31. PMID: 34057284; PMCID: PMC8630090.
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Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population.

Neurology

Angevaare MJ, Vonk JMJ, Bertola L, Zahodne L, Watson CW, Boehme A, Schupf N, Mayeux R, Geerlings MI, Manly JJ.
PMID: 34853178
Neurology. 2022 Jan 04;98(1):e15-e26. doi: 10.1212/WNL.0000000000013017. Epub 2021 Dec 01.

BACKGROUND AND OBJECTIVES: To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia.METHODS: Within a community-based cohort, diagnoses...

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Angevaare MJ, Vonk JMJ, Bertola L, et al. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology. 2021;98(1):e15-e26doi: 10.1212/WNL.0000000000013017.
Angevaare, M. J., Vonk, J. M. J., Bertola, L., Zahodne, L., Watson, C. W., Boehme, A., Schupf, N., Mayeux, R., Geerlings, M. I., & Manly, J. J. (2022). Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology, 98(1), e15-e26. https://doi.org/10.1212/WNL.0000000000013017
Angevaare, Milou J, et al. "Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population." Neurology vol. 98,1 (2022): e15-e26. doi: https://doi.org/10.1212/WNL.0000000000013017
Angevaare MJ, Vonk JMJ, Bertola L, Zahodne L, Watson CW, Boehme A, Schupf N, Mayeux R, Geerlings MI, Manly JJ. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology. 2022 Jan 04;98(1):e15-e26. doi: 10.1212/WNL.0000000000013017. Epub 2021 Dec 01. PMID: 34853178; PMCID: PMC8726570.
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Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population.

Neurology

Angevaare MJ, Vonk JMJ, Bertola L, Zahodne L, Watson CW, Boehme A, Schupf N, Mayeux R, Geerlings MI, Manly JJ.
PMID: 34853178
Neurology. 2022 Jan 04;98(1):e15-e26. doi: 10.1212/WNL.0000000000013017. Epub 2021 Dec 01.

BACKGROUND AND OBJECTIVES: To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia.METHODS: Within a community-based cohort, diagnoses...

Cite
Angevaare MJ, Vonk JMJ, Bertola L, et al. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology. 2021;98(1):e15-e26doi: 10.1212/WNL.0000000000013017.
Angevaare, M. J., Vonk, J. M. J., Bertola, L., Zahodne, L., Watson, C. W., Boehme, A., Schupf, N., Mayeux, R., Geerlings, M. I., & Manly, J. J. (2022). Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology, 98(1), e15-e26. https://doi.org/10.1212/WNL.0000000000013017
Angevaare, Milou J, et al. "Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population." Neurology vol. 98,1 (2022): e15-e26. doi: https://doi.org/10.1212/WNL.0000000000013017
Angevaare MJ, Vonk JMJ, Bertola L, Zahodne L, Watson CW, Boehme A, Schupf N, Mayeux R, Geerlings MI, Manly JJ. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population. Neurology. 2022 Jan 04;98(1):e15-e26. doi: 10.1212/WNL.0000000000013017. Epub 2021 Dec 01. PMID: 34853178; PMCID: PMC8726570.
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