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Showing 1 to 12 of 37 entries
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Ectopic Transplastomic Expression of a Synthetic MatK Gene Leads to Cotyledon-Specific Leaf Variegation.

Frontiers in plant science

Qu Y, Legen J, Arndt J, Henkel S, Hoppe G, Thieme C, Ranzini G, Muino JM, Weihe A, Ohler U, Weber G, Ostersetzer O, Schmitz-Linneweber C.
PMID: 30337934
Front Plant Sci. 2018 Oct 04;9:1453. doi: 10.3389/fpls.2018.01453. eCollection 2018.

Chloroplasts (and other plastids) harbor their own genetic material, with a bacterial-like gene-expression systems. Chloroplast RNA metabolism is complex and is predominantly mediated by nuclear-encoded RNA-binding proteins. In addition to these nuclear factors, the chloroplast-encoded intron maturase MatK has...

Down-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus suppresses OVCAR-3 cells proliferation and induction of apoptosis by Wnt/β-catenin.

The Journal of pharmacy and pharmacology

Sun L, Cui Y, Jiang K, Li J.
PMID: 33772549
J Pharm Pharmacol. 2021 Aug 12;73(9):1212-1217. doi: 10.1093/jpp/rgab042.

OBJECTIVES: Ovarian cancer is a lethal gynecological malignancy. Long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) was reported to have a critical role in cancer advancement. The ANRIL-mediated oncogenic underlying molecular mechanisms are not fully...

Predictive value of using plasma long non-coding RNAs ANRIL and HOXA11-AS for in-stent restenosis.

Experimental and therapeutic medicine

Jin Z, Shen H, Cha W, Xia H, Liu L.
PMID: 34970338
Exp Ther Med. 2022 Feb;23(2):115. doi: 10.3892/etm.2021.11038. Epub 2021 Dec 06.

In-stent restenosis (ISR) can pose serious challenges for cardiologists following coronary stent implantation. Early identification of patients at high risk of ISR is considered to be effective for its prevention. However, factors that can reliably predict the risk of...

Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms.

Sarcoma

Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC.
PMID: 18521197
Sarcoma. 1997;1(1):23-9. doi: 10.1080/13577149778443.

Purpose. MDM2 is an oncogene whose protein product may promote tumorigenesis by blocking wild-type p53 tumor suppressor mediated G (0)/G(1) cell cycle arrest, thereby inhibiting repair of damaged DNA prior to cell division. While MDM2 DNA amplification is frequently...

Identification of HnRNPC as a novel Tau exon 10 splicing factor using RNA antisense purification mass spectrometry.

RNA biology

Xing S, Wang J, Wu R, Hefti MM, Crary JF, Lu Y.
PMID: 34965173
RNA Biol. 2021 Dec 29;1-13. doi: 10.1080/15476286.2021.2015175. Epub 2021 Dec 29.

Alternative splicing in Tau exon 10 generates 3 R- and 4 R-Tau proteoforms, which have equal abundance in healthy adult human brain. Aberrant alternative splicing in Tau exon 10 leads to distortion of the balanced 3 R- and 4...

Predictive value of using plasma long non-coding RNAs ANRIL and HOXA11-AS for in-stent restenosis.

Experimental and therapeutic medicine

Jin Z, Shen H, Cha W, Xia H, Liu L.
PMID: 34970338
Exp Ther Med. 2022 Feb;23(2):115. doi: 10.3892/etm.2021.11038. Epub 2021 Dec 06.

In-stent restenosis (ISR) can pose serious challenges for cardiologists following coronary stent implantation. Early identification of patients at high risk of ISR is considered to be effective for its prevention. However, factors that can reliably predict the risk of...

Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1.

Cell reports

Desideri F, Cipriano A, Petrezselyova S, Buonaiuto G, Santini T, Kasparek P, Prochazka J, Janson G, Paiardini A, Calicchio A, Colantoni A, Sedlacek R, Bozzoni I, Ballarino M.
PMID: 33357424
Cell Rep. 2020 Dec 22;33(12):108548. doi: 10.1016/j.celrep.2020.108548.

Chromatin architect of muscle expression (Charme) is a muscle-restricted long noncoding RNA (lncRNA) that plays an important role in myogenesis. Earlier evidence indicates that the nuclear Charme isoform, named pCharme, acts on the chromatin by assisting the formation of...

CircRNA ACAP2 induces myocardial apoptosis after myocardial infarction by sponging miR-29.

Minerva medica

Liu X, Wang M, Li Q, Liu W, Song Q, Jiang H.
PMID: 32406223
Minerva Med. 2020 May 13; doi: 10.23736/S0026-4806.20.06600-8. Epub 2020 May 13.

BACKGROUND: To investigate the effect of circular RNA circ ACAP2 on apoptotic phenotype of rat cardiomyocytes and its molecular mechanism.METHODS: Left anterior descending ligation was used to establish a rat myocardial infarction (MI) model, and real-time quantitative polymerase chain...

MALAT1 downregulation is associated with polycystic ovary syndrome via binding with MDM2 and repressing P53 degradation.

Molecular and cellular endocrinology

Li Y, Xiang Y, Song Y, Zhang D, Tan L.
PMID: 34883204
Mol Cell Endocrinol. 2021 Dec 06;543:111528. doi: 10.1016/j.mce.2021.111528. Epub 2021 Dec 06.

Polycystic ovary syndrome (PCOS) is a metabolic disorder of the reproductive system that affects 6-20% women of reproductive age. Multiple coding and non-coding genes were found to be affected in patients with PCOS, including MALAT1, an 8.7 kb long...

Long noncoding RNA ANRIL as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis.

Oncotarget

Wang H, Liu Y, Zhong J, Wu C, Zhong Y, Yang G, Zhang J, Tang A.
PMID: 29581867
Oncotarget. 2017 Oct 11;9(18):14608-14618. doi: 10.18632/oncotarget.21825. eCollection 2018 Mar 06.

Dysregulation of the long noncoding RNA antisense noncoding RNA in the INK4 locus (ANRIL) has been reported in various solid tumors. We performed a synthetic analysis to clarify the clinical value of ANRIL as a prognostic indicator in malignant...

RNA Therapy: Current Status and Future Potential.

Chonnam medical journal

Kim YK.
PMID: 32509554
Chonnam Med J. 2020 May;56(2):87-93. doi: 10.4068/cmj.2020.56.2.87. Epub 2020 May 25.

Recent studies identified diverse RNAs including noncoding RNAs and their various action mechanisms in the cells. These RNAs regulate a variety of cellular pathways and are therefore expected to be important targets for the treatment of human diseases. Along...

LncRNA ADAMTS9-AS1 knockdown suppresses cell proliferation and migration in glioma via down-regulating Wnt/β-catenin signaling pathway.

Bosnian journal of basic medical sciences

Zhou C, Zhao H, Wang S, Dong C, Yang F, Zhang J.
PMID: 34923953
Bosn J Basic Med Sci. 2021 Dec 11; doi: 10.17305/bjbms.2021.6199. Epub 2021 Dec 11.

The long non-coding RNA antisense 1 ADAMTS9-AS1 has been reported to serve as an oncogene or tumor suppressor in several tumors, including colorectal cancer and hepatocellular carcinoma. Nevertheless, the clinical significance and biological behaviors of ADAMTS9-AS1 in glioma still...

Showing 1 to 12 of 37 entries