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Showing 1 to 12 of 28 entries
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Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses.

Circulation research

Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S.
PMID: 34789007
Circ Res. 2022 Jan 07;130(1):67-79. doi: 10.1161/CIRCRESAHA.121.320029. Epub 2021 Nov 18.

BACKGROUND: Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However, their physiological roles and functional conservation in vivo are...

Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.

Journal of lipid and atherosclerosis

Kim YK.
PMID: 32821699
J Lipid Atheroscler. 2019 May;8(1):50-57. doi: 10.12997/jla.2019.8.1.50. Epub 2019 Mar 29.

OBJECTIVES: Kawasaki disease is a disease in children that presents with diverse symptoms including acute fever, conjunctivitis, body rash, swollen lymph nodes of the neck, and peeling of the skin on the hands and feet. Although patients with Kawasaki...

Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats.

iScience

Yoshimoto R, Rahimi K, Hansen TB, Kjems J, Mayeda A.
PMID: 32683316
iScience. 2020 Jul 24;23(7):101345. doi: 10.1016/j.isci.2020.101345. Epub 2020 Jul 04.

Circular RNAs (circRNAs) are stable non-coding RNAs with a closed circular structure. One of the best studied circRNAs is ciRS-7 (CDR1as), which acts as a regulator of the microRNA miR-7; however, its biosynthetic pathway has remained an enigma. Here...

Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.

Circulation

Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH.
PMID: 33207953
Circulation. 2021 Jan 26;143(4):354-371. doi: 10.1161/CIRCULATIONAHA.120.049715. Epub 2020 Nov 19.

BACKGROUND: Aberrant expression of circular RNA contributes to human diseases. Circular RNAs regulate gene expression by sequestering specific microRNAs. In this study, we investigated whether circMAP3K5 (circular mitogen-activated protein kinase 5) could act as a competing endogenous microRNA-22-3p (miR-22-3p)...

circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.

Translational lung cancer research

Dong Y, Qiu T, Xuan Y, Liu A, Sun X, Huang Z, Su W, Du W, Yun T, Wo Y, Navarro A, Jiao W.
PMID: 33889522
Transl Lung Cancer Res. 2021 Mar;10(3):1457-1473. doi: 10.21037/tlcr-21-230.

BACKGROUND: As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number of circRNAs have been verified in malignant progression in a number of cancers. The circRNA, circFBXW7,...

circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis.

Frontiers in genetics

Liu P, Zou Y, Li X, Yang A, Ye F, Zhang J, Wei W, Kong Y.
PMID: 32194644
Front Genet. 2020 Mar 05;11:193. doi: 10.3389/fgene.2020.00193. eCollection 2020.

As an intriguing class of RNA, circular RNAs (circRNAs) are vital mediators of various diseases including cancers. However, the biological role and underlying mechanism of the majority of circRNAs are still ambiguous in the progression of triple-negative breast cancer...

circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion.

Molecular therapy. Nucleic acids

Tang M, Bai L, Wan Z, Wan S, Xiang Y, Qian Y, Cui L, You J, Hu X, Qu F, Zhu Y.
PMID: 34938599
Mol Ther Nucleic Acids. 2021 Jun 24;26:1433-1445. doi: 10.1016/j.omtn.2021.06.012. eCollection 2021 Dec 03.

Unexplained recurrent spontaneous abortion (URSA) is one of the most intractable clinical challenges in reproduction. As a specific type of endogenous non-coding RNA, circular RNAs (circRNAs) have great pre-clinical diagnostic and therapeutic values in diseases. Recently, thousands of circRNAs...

Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing.

Circulation

Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts KY, Engelhardt S, Gepstein L, Ware JS, Pinto YM.
PMID: 33583186
Circulation. 2021 Apr 13;143(15):1502-1512. doi: 10.1161/CIRCULATIONAHA.120.050455. Epub 2021 Feb 15.

BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the METHODS: We calculated genetic constraint of the identified motif in...

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses.

Circulation research

Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S.
PMID: 34789007
Circ Res. 2022 Jan 07;130(1):67-79. doi: 10.1161/CIRCRESAHA.121.320029. Epub 2021 Nov 18.

BACKGROUND: Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However, their physiological roles and functional conservation in vivo are...

Non-Invasive Early Molecular Detection of Gastric Cancers.

Cancers

Yamamoto H, Watanabe Y, Sato Y, Maehata T, Itoh F.
PMID: 33036473
Cancers (Basel). 2020 Oct 07;12(10). doi: 10.3390/cancers12102880.

Gastric cancer (GC) is a significant source of global cancer death with a high mortality rate, because the majority of patients with GC are diagnosed at a late stage, with limited therapeutic choices and poor outcomes. Therefore, development of...

Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing.

Circulation

Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts KY, Engelhardt S, Gepstein L, Ware JS, Pinto YM.
PMID: 33583186
Circulation. 2021 Apr 13;143(15):1502-1512. doi: 10.1161/CIRCULATIONAHA.120.050455. Epub 2021 Feb 15.

BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the METHODS: We calculated genetic constraint of the identified motif in...

Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis.

Cell death discovery

Huang K, Yang C, Zheng J, Liu X, Liu J, Che D, Xue Y, An P, Wang D, Ruan X, Yu B.
PMID: 34052838
Cell Death Discov. 2021 May 29;7(1):124. doi: 10.1038/s41420-021-00507-y.

Chronic cerebral ischaemia (CCI) is a common pathological disorder, which is associated with various diseases, such as cerebral arteriosclerosis and vascular dementia, resulting in neurological dysfunction. As a type of non-coding RNA, circular RNA is involved in regulating the...

Showing 1 to 12 of 28 entries