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Showing 1 to 10 of 10 entries
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Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer.

Journal of breast cancer

Kim D, Lee J, Kang J, Kim SH, Yoo TK, Oh S, Lee A.
PMID: 31897330
J Breast Cancer. 2019 Dec 12;22(4):562-578. doi: 10.4048/jbc.2019.22.e56. eCollection 2019 Dec.

PURPOSE: Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results in modest clinical benefits. In this study, we analyzed...

Quantitative DNA hypomethylation of ligand Jagged1 and receptor Notch1 signifies occurrence and progression of breast carcinoma.

American journal of cancer research

Cao Y, Li Y, Zhang N, Hu J, Yin L, Pan Z, Li Y, Du X, Zhang W, Li F.
PMID: 26269752
Am J Cancer Res. 2015 May 15;5(6):1897-910. eCollection 2015.

Methylation alterations of Jagged1 and Notch1 genes have been reported in non-tumor lesions and a few cancers. However, methylation profiles of Jagged1 promoter and Notch1 exon25 in breast cancer and matched normal tissue and the association of methylation with...

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.

Molecular oncology

Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV.
PMID: 33314742
Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13.

The cellular receptor Notch1 is a central regulator of T-cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T-cell acute lymphoblastic leukemia (T-ALL). However, strategies targeting Notch1 signaling render only modest...

Quantitative DNA hypomethylation of ligand Jagged1 and receptor Notch1 signifies occurrence and progression of breast carcinoma.

American journal of cancer research

Cao Y, Li Y, Zhang N, Hu J, Yin L, Pan Z, Li Y, Du X, Zhang W, Li F.
PMID: 26175933
Am J Cancer Res. 2015 Apr 15;5(5):1621-34. eCollection 2015.

Methylation alterations of Jagged1 and Notch1 genes have been reported in non-tumor lesions and a few cancers. However, methylation profiles of Jagged1 promoter and Notch1 exon25 in breast cancer and matched normal tissue and the association of methylation with...

Jagged1 contributes to the drug resistance of Jurkat cells in contact with human umbilical cord-derived mesenchymal stem cells.

Oncology letters

Yuan Y, Lu X, Chen X, Shao H, Huang S.
PMID: 24137453
Oncol Lett. 2013 Oct;6(4):1000-1006. doi: 10.3892/ol.2013.1523. Epub 2013 Aug 12.

Notch signaling, which is driven by the Notch1 receptor, plays an essential role in the pathogenesis and stroma-mediated drug resistance of T-cell acute lymphoblastic leukemia (T-ALL). However, little is known about the roles of Notch ligands in the survival...

Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-dependent Notch1 and adenosine 5'-monophosphate-activated protein kinase.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Wu J, Chen X, Guo S, Liu W, Zhang L, Li F, Wu J, Huang X, Cai Q, Tan X, Wang H.
PMID: 31682381
J Tradit Chin Med. 2017 Jun;37(3):378-386.

OBJECTIVE: To investigate the effect of Yiqihuoxue prescription (YQHX) from Traditional Chinese Medicine (TCM) on myocardial glucose and lipid metabolism after myocardial infarction via the cross talk between the liver kinase B1 (LKB1)-dependent Notch1 and adenosine 5'-monophosphate (AMP)-activated protein...

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.

Molecular oncology

Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV.
PMID: 33314742
Mol Oncol. 2021 May;15(5):1412-1431. doi: 10.1002/1878-0261.12877. Epub 2021 Feb 13.

The cellular receptor Notch1 is a central regulator of T-cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T-cell acute lymphoblastic leukemia (T-ALL). However, strategies targeting Notch1 signaling render only modest...

Quantitative DNA hypomethylation of ligand Jagged1 and receptor Notch1 signifies occurrence and progression of breast carcinoma [Retraction].

American journal of cancer research

[No authors listed]
PMID: 27822429
Am J Cancer Res. 2016 Oct 01;6(10):2388. eCollection 2016.

[This retracts the article on p. 1897 in vol. 5, PMID: 26269752.].

Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/ matrix metalloproteinase-13 signaling pathway.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Lai QZ, Zhang XJ, Chen ML, Han ZC.
PMID: 34392653
J Tradit Chin Med. 2021 Aug;41(4):600-607. doi: 10.19852/j.cnki.jtcm.2021.03.012.

OBJECTIVE: This study investigated the effect of salvia miltiorrhiza-asarum ointment (SMAO) plus Chinese medical massage on knee osteoarthritis in a rat model.METHODS: Hulth's method was used to establish a Sprague-Dawley rat model of knee osteoarthritis (OA). The levels of...

Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway.

Cancer cell international

Hu J, Huang X, Hong X, Lu Q, Zhu X.
PMID: 23497375
Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.

Arsenic Trioxide (ATO) has shown remarkable efficacy for the treatment of multiple myeloma (MM). However, the mechanism by which ATO exerts its inhibitory effect on the proliferation of myeloma cells remains to be clarified. We study the inhibitory effect...

Showing 1 to 10 of 10 entries