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Showing 1 to 12 of 137 entries
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SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury.

Frontiers in cellular neuroscience

Jones EV, Bernardinelli Y, Zarruk JG, Chierzi S, Murai KK.
PMID: 29449802
Front Cell Neurosci. 2018 Feb 01;12:22. doi: 10.3389/fncel.2018.00022. eCollection 2018.

The proper formation and maintenance of functional synapses in the central nervous system (CNS) requires communication between neurons and astrocytes and the ability of astrocytes to release neuromodulatory molecules. Previously, we described a novel role for the astrocyte-secreted matricellular...

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity.

Frontiers in cellular neuroscience

Chater TE, Goda Y.
PMID: 25505875
Front Cell Neurosci. 2014 Nov 27;8:401. doi: 10.3389/fncel.2014.00401. eCollection 2014.

In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). AMPARs, which are enriched in the postsynaptic membrane on dendritic spines, are highly dynamic, and shuttle in...

TNFalpha-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity?.

Neuron glia biology

Leonoudakis D, Braithwaite SP, Beattie MS, Beattie EC.
PMID: 16520832
Neuron Glia Biol. 2004 Aug;1(3):263-73. doi: 10.1017/S1740925X05000608.

Injury and disease in the CNS increases the amount of tumor necrosis factor alpha (TNFalpha) that neurons are exposed to. This cytokine is central to the inflammatory response that occurs after injury and during prolonged CNS disease, and contributes...

Society for Neuroscience--28th annual meeting. Glutamate receptors. 7-12 November 1998, Los Angeles, CA, USA.

IDrugs : the investigational drugs journal

Salt T.
PMID: 16180155
IDrugs. 1999 Jan;2(1):1-3.

This meeting, stretching over 5 days with approximately 24,000 registrants, had approximately 13,000 oral and poster presentations covering all areas of neuroscience. This review focuses on a selection of new developments in the field of glutamate receptors. This area...

Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review).

Biomedical reports

Tang XJ, Xing F.
PMID: 24649036
Biomed Rep. 2013 Nov;1(6):828-832. doi: 10.3892/br.2013.154. Epub 2013 Jul 30.

Hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and may result in long-term devastating consequences. Excessive stimulation of glutamate receptors (GluRs) is a pivotal mechanism underlying ischemia-induced selective and delayed neuronal death. Although initial...

Dysregulated Ca.

Frontiers in synaptic neuroscience

Danesi C, Keinänen K, Castrén ML.
PMID: 30800064
Front Synaptic Neurosci. 2019 Feb 08;11:2. doi: 10.3389/fnsyn.2019.00002. eCollection 2019.

Fragile X syndrome (FXS) is a neurodevelopmental disorder that represents a common cause of intellectual disability and is a variant of autism spectrum disorder (ASD). Studies that have searched for similarities in syndromic and non-syndromic forms of ASD have...

Ca.

Frontiers in synaptic neuroscience

Chowdhury D, Hell JW.
PMID: 30914943
Front Synaptic Neurosci. 2019 Mar 12;11:6. doi: 10.3389/fnsyn.2019.00006. eCollection 2019.

AMPA-type glutamate receptors (AMPARs) are clustered into functional nanodomains at postsynaptic sites through anchorage by the scaffolding protein, postsynaptic density protein-95 (PSD-95). The synaptic abundance of AMPARs is dynamically controlled in various forms of synaptic plasticity. Removal of AMPARs...

Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABA.

Frontiers in behavioral neuroscience

Ucha M, Roura-Martínez D, Contreras A, Pinto-Rivero S, Orihuel J, Ambrosio E, Higuera-Matas A.
PMID: 30842730
Front Behav Neurosci. 2019 Feb 20;13:22. doi: 10.3389/fnbeh.2019.00022. eCollection 2019.

The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase...

Mechanisms of AMPA Receptor Endosomal Sorting.

Frontiers in molecular neuroscience

Parkinson GT, Hanley JG.
PMID: 30568574
Front Mol Neurosci. 2018 Dec 05;11:440. doi: 10.3389/fnmol.2018.00440. eCollection 2018.

The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes. The number of synaptic AMPARs is...

CX691, as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer's disease.

Iranian journal of basic medical sciences

Mozafari N, Shamsizadeh A, Fatemi I, Allahtavakoli M, Moghadam-Ahmadi A, Kaviani E, Kaeidi A.
PMID: 30140412
Iran J Basic Med Sci. 2018 Jul;21(7):724-730. doi: 10.22038/IJBMS.2018.28544.6934.

OBJECTIVES: Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer's disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors...

Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders.

Frontiers in synaptic neuroscience

Zhang H, Bramham CR.
PMID: 32754026
Front Synaptic Neurosci. 2020 Jul 10;12:26. doi: 10.3389/fnsyn.2020.00026. eCollection 2020.

AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal mechanisms in synaptic plasticity, such as long-term potentiation (LTP)...

NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms.

Cell reports

Zhou Z, He G, Zhang X, Lv X, Zhang X, Liu A, Xia S, Xie H, Dang R, Han L, Qi J, Meng Y, Yu S, Xie W, Jia Z.
PMID: 34407403
Cell Rep. 2021 Aug 17;36(7):109515. doi: 10.1016/j.celrep.2021.109515.

Synaptic scaling is an extensively studied form of homeostatic plasticity critically involved in various brain functions. Although it is accepted that synaptic scaling is expressed through the postsynaptic accumulation of AMPA receptors (AMPARs), the induction mechanism remains elusive. In...

Showing 1 to 12 of 137 entries