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Showing 1 to 12 of 14 entries
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Astroglial Glutamate Signaling and Uptake in the Hippocampus.

Frontiers in molecular neuroscience

Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C.
PMID: 29386994
Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017.

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond to glutamate...

Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons.

Pain

Xia J, Dou Y, Mei Y, Munoz FM, Gao R, Gao X, Li D, Osei-Owusu P, Schiffenhaus J, Bekker A, Tao YX, Hu H.
PMID: 34252911
Pain. 2021 Jul 08; doi: 10.1097/j.pain.0000000000002396. Epub 2021 Jul 08.

ABSTRACT: Group I metabotropic glutamate receptors (mGluR1 and mGluR5, mGluR1/5) have been implicated in several CNS diseases including chronic pain. It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads...

Putative roles of astrocytes in general anesthesia.

Current neuropharmacology

Mulkey DK, Olsen ML, Ou M, Cleary CM, Du G.
PMID: 33588730
Curr Neuropharmacol. 2021 Feb 15; doi: 10.2174/1570159X19666210215120755. Epub 2021 Feb 15.

General anesthetics are a mainstay of modern medicine, and although much progress has been made towards identifying molecular targets of anesthetics and neural networks contributing to endpoints of general anesthesia, our understanding of how anesthetics work remains unclear. Reducing...

Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons.

Pain

Xia J, Dou Y, Mei Y, Munoz FM, Gao R, Gao X, Li D, Osei-Owusu P, Schiffenhaus J, Bekker A, Tao YX, Hu H.
PMID: 34252911
Pain. 2021 Jul 08; doi: 10.1097/j.pain.0000000000002396. Epub 2021 Jul 08.

ABSTRACT: Group I metabotropic glutamate receptors (mGluR1 and mGluR5, mGluR1/5) have been implicated in several CNS diseases including chronic pain. It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads...

Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept.

Current opinion in anaesthesiology

Grasshoff C, Rudolph U, Antkowiak B.
PMID: 16534263
Curr Opin Anaesthesiol. 2005 Aug;18(4):386-91. doi: 10.1097/01.aco.0000174961.90135.dc.

PURPOSE OF REVIEW: Amnesia, hypnosis and immobility are essential components of general anaesthesia. This review highlights recent advances in our understanding of how these components are achieved at a molecular level.RECENT FINDINGS: Commonly used volatile anaesthetic agents such as...

Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons.

Pain

Xia J, Dou Y, Mei Y, Munoz FM, Gao R, Gao X, Li D, Osei-Owusu P, Schiffenhaus J, Bekker A, Tao YX, Hu H.
PMID: 34252911
Pain. 2021 Jul 08; doi: 10.1097/j.pain.0000000000002396. Epub 2021 Jul 08.

ABSTRACT: Group I metabotropic glutamate receptors (mGluR1 and mGluR5, mGluR1/5) have been implicated in several CNS diseases including chronic pain. It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads...

Putative roles of astrocytes in general anesthesia.

Current neuropharmacology

Mulkey DK, Olsen ML, Ou M, Cleary CM, Du G.
PMID: 33588730
Curr Neuropharmacol. 2021 Feb 15; doi: 10.2174/1570159X19666210215120755. Epub 2021 Feb 15.

General anesthetics are a mainstay of modern medicine, and although much progress has been made towards identifying molecular targets of anesthetics and neural networks contributing to endpoints of general anesthesia, our understanding of how anesthetics work remains unclear. Reducing...

Interaction between glutamate signalling and immune attack in damaging oligodendrocytes.

Neuron glia biology

Matute C.
PMID: 18634560
Neuron Glia Biol. 2007 Nov;3(4):281-5. doi: 10.1017/S1740925X08000033.

Glutamate is the principal excitatory neurotransmitter in the CNS, but it is also a potent neurotoxin that can kill nerve cells. Glutamate damages oligodendrocytes, like neurons, by excitotoxicity which is caused by sustained activation of AMPA, kainate and NMDA...

Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases.

Scientifica

Ishikawa M.
PMID: 24386591
Scientifica (Cairo). 2013;2013:528940. doi: 10.1155/2013/528940. Epub 2013 Dec 09.

In the physiological condition, glutamate acts as an excitatory neurotransmitter in the retina. However, excessive glutamate can be toxic to retinal neurons by overstimulation of the glutamate receptors. Glutamate excess is primarily attributed to perturbation in the homeostasis of...

Dietary glutamate: interactions with the enteric nervous system.

Journal of neurogastroenterology and motility

Wang GD, Wang XY, Xia Y, Wood JD.
PMID: 24466444
J Neurogastroenterol Motil. 2014 Jan;20(1):41-53. doi: 10.5056/jnm.2014.20.1.41. Epub 2013 Dec 30.

BACKGROUND/AIMS: Digestion of dietary protein elevates intraluminal concentrations of glutamate in the small intestine, some of which gain access to the enteric nervous system (ENS). Glutamate, in the central nervous system (CNS), is an excitatory neurotransmitter. A dogma that...

Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats.

Frontiers in pharmacology

Wang L, Zhang M, Wen J, Xiang Y, Duan X, Yu C, Yan M, Zhang B, Fang P.
PMID: 34867385
Front Pharmacol. 2021 Nov 15;12:762290. doi: 10.3389/fphar.2021.762290. eCollection 2021.

Acute neurotoxicity of Semen Strychni can result in sudden death in epilepsy. The detoxification method and mechanism of Semen Strychni acute poisoning have not been clarified. This experiment focused on the mechanism of Semen Strychni neurotoxicity and the alleviation...

Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity.

Neuropharmacology

Farhat F, Nofal S, Raafat EM, Eissa Ahmed AA.
PMID: 34119518
Neuropharmacology. 2021 Sep 15;196:108654. doi: 10.1016/j.neuropharm.2021.108654. Epub 2021 Jun 11.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates redox homeostasis of the cell through regulation of the antioxidant response element genes transcription. Nrf2 also regulates the antiapoptotic Bcl-2 gene. Nrf2 degradation and nuclear translocation...

Showing 1 to 12 of 14 entries