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Showing 1 to 12 of 17 entries
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Novel insights into the differential functions of Notch ligands in vascular formation.

Journal of angiogenesis research

Kume T.
PMID: 20016694
J Angiogenes Res. 2009 Nov 16;1:8. doi: 10.1186/2040-2384-1-8.

The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of...

Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells.

Journal of Cancer

Liu H, Zhou P, Lan H, Chen J, Zhang YX.
PMID: 28123599
J Cancer. 2017 Jan 01;8(1):65-73. doi: 10.7150/jca.16739. eCollection 2017.

Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2,...

A Comprehensive Bioinformatics Analysis of Notch Pathways in Bladder Cancer.

Cancers

Zhang C, Berndt-Paetz M, Neuhaus J.
PMID: 34205690
Cancers (Basel). 2021 Jun 21;13(12). doi: 10.3390/cancers13123089.

BACKGROUND: A hallmark of Notch signaling is its variable role in tumor biology, ranging from tumor-suppressive to oncogenic effects. Until now, the mechanisms and functions of Notch pathways in bladder cancer (BCa) are still unclear.METHODS: We used publicly available...

Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation.

Iranian journal of basic medical sciences

Amjadi F, Salehi E, Zandieh Z, Rashidi M, Taleahmad S, Javedani Masrour M, Aflatoonian R, Mehdizadeh M.
PMID: 31168348
Iran J Basic Med Sci. 2019 Apr;22(4):426-431. doi: 10.22038/ijbms.2019.32961.7874.

OBJECTIVES: NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial function and implantation in animals and appear to play a...

A Comprehensive Bioinformatic Analysis of NOTCH Pathway Involvement in Stomach Adenocarcinoma.

Disease markers

Xue D, Li D, Dou C, Li J.
PMID: 34925644
Dis Markers. 2021 Dec 08;2021:4739868. doi: 10.1155/2021/4739868. eCollection 2021.

BACKGROUND: Activation of NOTCH signaling pathways, which are key regulators of multiple cellular functions, has been frequently implicated in cancer pathogenesis, and NOTCH inhibitors have received much recent focus in the context of cancer therapeutics. However, the role and...

Frequent Activation of Notch Signaling Pathway in Colorectal Cancers and Its Implication in Patient Survival Outcome.

Journal of oncology

Shaik JP, Alanazi IO, Pathan AAK, Parine NR, Almadi MA, Azzam NA, Aljebreen AM, Alharbi O, Alanazi MS, Khan Z.
PMID: 32211044
J Oncol. 2020 Mar 09;2020:6768942. doi: 10.1155/2020/6768942. eCollection 2020.

Colorectal cancer is a major health concern as it ranks third in incidence and second major cause of cancer-related deaths worldwide. A leading cause of treatment failure has been attributed to cancer stem cells that can invariably resist existing...

Role of Notch Signaling Pathway in Glioblastoma Pathogenesis.

Cancers

Bazzoni R, Bentivegna A.
PMID: 30832246
Cancers (Basel). 2019 Mar 01;11(3). doi: 10.3390/cancers11030292.

Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1⁻4) and five ligands (Dll1-3⁻4, Jagged1⁻2) that mainly contribute...

Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.

Journal of oncology

Giuli MV, Giuliani E, Screpanti I, Bellavia D, Checquolo S.
PMID: 31379945
J Oncol. 2019 Jul 11;2019:8707053. doi: 10.1155/2019/8707053. eCollection 2019.

Triple-negative breast cancer (TNBC) is a subgroup of 15%-20% of diagnosed breast cancer patients. It is generally considered to be the most difficult breast cancer subtype to deal with, due to the lack of estrogen receptor (ER), progesterone receptor...

Expression of Notch receptors and their ligands in pancreatic ductal adenocarcinoma.

Experimental and therapeutic medicine

Song HY, Wang Y, Lan H, Zhang YX.
PMID: 29896227
Exp Ther Med. 2018 Jul;16(1):53-60. doi: 10.3892/etm.2018.6172. Epub 2018 May 16.

Pancreatic cancer is the fourth leading cause of cancer-associated mortality in developed countries. Pancreatic ductal adenocarcinoma (PDAC) accounts for ~90% of all pancreatic cancer cases. The Notch signaling pathway serves a crucial role in embryonic development, as well as...

NOTCH signaling in the pathogenesis of splenic marginal zone lymphoma-opportunities for therapy.

Leukemia & lymphoma

Alderuccio JP, Lossos IS.
PMID: 34586000
Leuk Lymphoma. 2021 Sep 29;1-12. doi: 10.1080/10428194.2021.1984452. Epub 2021 Sep 29.

NOTCH signaling is a highly conserved pathway mediated by four receptors (NOTCH 1-4) playing critical functions in proliferation, differentiation, and cell death. Under physiologic circumstances,

Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.

Results in immunology

Bento-de-Souza L, Victor JR, Bento-de-Souza LC, Arrais-Santos M, Rangel-Santos AC, Pereira-Costa É, Raniero-Fernandes E, Seixas-Duarte MI, Oliveira-Filho JB, Silva Duarte AJ.
PMID: 27504259
Results Immunol. 2016 Apr 05;6:15-20. doi: 10.1016/j.rinim.2016.04.001. eCollection 2016.

The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T...

Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance.

World journal of clinical oncology

Daley-Brown D, Harbuzariu A, Kurian AA, Oprea-Ilies G, Gonzalez-Perez RR.
PMID: 31367531
World J Clin Oncol. 2019 Jun 24;10(6):222-233. doi: 10.5306/wjco.v10.i6.222.

BACKGROUND: Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer...

Showing 1 to 12 of 17 entries