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Showing 1 to 5 of 5 entries
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The impact of commercially available purinergic ligands on purinergic signalling research.

Purinergic signalling

Flanaghan JR, Roome SJ.
PMID: 22038574
Purinergic Signal. 2012 Feb;8:81-9. doi: 10.1007/s11302-011-9269-0. Epub 2011 Oct 27.

Due to the extremely wide-spread expression of purinergic receptors, purinergic signalling has been implicated in numerous physiological and pathophysiological areas. To better understand the involvement of purinergic receptors in such areas, the researcher's requirement for diverse and varied purinergic...

Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.

The open drug discovery journal

Crain JM, Watters JJ.
PMID: 21961028
Open Drug Discov J. 2010 Jan 01;2:148-167. doi: 10.2174/1877381801002010148.

Microglia, the primary resident immune cell population in the CNS, react to signals of injury or infection and produce inflammatory cytokines, chemokines, and reactive oxygen species, many of which can be neurotoxic in large quantities. Indeed microglial hyperactivation is...

Newer agents in antiplatelet therapy: a review.

Journal of blood medicine

Yeung J, Holinstat M.
PMID: 22792011
J Blood Med. 2012;3:33-42. doi: 10.2147/JBM.S25421. Epub 2012 Jun 25.

Antiplatelet therapy remains the mainstay in preventing aberrant platelet activation in pathophysiological conditions such as myocardial infarction, ischemia, and stroke. Although there has been significant advancement in antiplatelet therapeutic approaches, aspirin still remains the gold standard treatment in the...

Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine.

Chonnam medical journal

Park IK, Kim JH, Park CG, Kim MY, Parajuli SP, Hong CS, Choi S, Jun JY.
PMID: 29399568
Chonnam Med J. 2018 Jan;54(1):63-71. doi: 10.4068/cmj.2018.54.1.63. Epub 2018 Jan 25.

Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles of external adenosine 5'-triphosphate (ATP) on pacemaker activity in...

Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson's Disease.

Frontiers in aging neuroscience

Gu C, Chen Y, Chen Y, Liu CF, Zhu Z, Wang M.
PMID: 34867296
Front Aging Neurosci. 2021 Nov 16;13:768156. doi: 10.3389/fnagi.2021.768156. eCollection 2021.

Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases associated with preferential loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and accumulation of α-synuclein in DA neurons. Even though the precise pathogenesis of PD is...

Showing 1 to 5 of 5 entries