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Showing 1 to 12 of 64 entries
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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression.

Clinical and molecular allergy : CMA

Wansley DL, Yin Y, Prussin C.
PMID: 24314292
Clin Mol Allergy. 2013 Dec 06;11(1):4. doi: 10.1186/1476-7961-11-4.

BACKGROUND: Th2 cytokine responses are enhanced by all trans retinoic acid (ATRA), the bioavailable form of vitamin A. Retinoic acid receptor alpha (RARα) is the high affinity receptor for ATRA that mediates these pro-Th2 effects. We have previously characterized...

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Wansley DL, Yin Y, Prussin C. The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression. Clin Mol Allergy. 2013;11(1):4doi: 10.1186/1476-7961-11-4.
Wansley, D. L., Yin, Y., & Prussin, C. (2013). The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression. Clinical and molecular allergy : CMA, 11(1), 4. https://doi.org/10.1186/1476-7961-11-4
Wansley, Daniel L, et al. "The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression." Clinical and molecular allergy : CMA vol. 11,1 (2013): 4. doi: https://doi.org/10.1186/1476-7961-11-4
Wansley DL, Yin Y, Prussin C. The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression. Clin Mol Allergy. 2013 Dec 06;11(1):4. doi: 10.1186/1476-7961-11-4. PMID: 24314292; PMCID: PMC3882882.
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Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma.

Case reports in hematology

Overholt K, Guinipero TL, Heerema NA, Loken MR, Kahwash SB.
PMID: 26351594
Case Rep Hematol. 2015;2015:412016. doi: 10.1155/2015/412016. Epub 2015 Aug 17.

A case of acute promyelocytic leukemia (APL) with RUNX1T1 insertion to 7q is described and compared to reported cases of APL with negative retinoic acid receptor alpha (RARA) abnormality. In this report, we describe the case of a 2-year-old...

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Overholt K, Guinipero TL, Heerema NA, et al. Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma. Case Rep Hematol. 2015;2015:412016doi: 10.1155/2015/412016.
Overholt, K., Guinipero, T. L., Heerema, N. A., Loken, M. R., & Kahwash, S. B. (2015). Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma. Case reports in hematology, 2015412016. https://doi.org/10.1155/2015/412016
Overholt, Kathleen, et al. "Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma." Case reports in hematology vol. 2015 (2015): 412016. doi: https://doi.org/10.1155/2015/412016
Overholt K, Guinipero TL, Heerema NA, Loken MR, Kahwash SB. Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma. Case Rep Hematol. 2015;2015:412016. doi: 10.1155/2015/412016. Epub 2015 Aug 17. PMID: 26351594; PMCID: PMC4553303.
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A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils.

Blood

Shibakura M, Koyama T, Ohsawa M, Kamiyama R, Hirosawa S.
PMID: 9427733
Blood. 1998 Jan 15;91(2):724b-725.

No abstract available.

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Shibakura M, Koyama T, Ohsawa M, et al. A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood. 1998;91(2):724b-725
Shibakura, M., Koyama, T., Ohsawa, M., Kamiyama, R., & Hirosawa, S. (1998). A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood, 91(2), 724b-725.
Shibakura, et al. "A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils." Blood vol. 91,2 (1998): 724b-725.
Shibakura M, Koyama T, Ohsawa M, Kamiyama R, Hirosawa S. A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood. 1998 Jan 15;91(2):724b-725. PMID: 9427733.
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Critical role of tyrosine 277 in the ligand-binding and transactivating properties of retinoic acid receptor alpha.

Biochemistry

Mailfait S, Belaiche D, Kouach M, Dallery N, Chavatte P, Formstecher P, Sablonniere B.
PMID: 10820036
Biochemistry. 2000 May 09;39(18):5622. doi: 10.1021/bi005107d.

No abstract available.

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Mailfait S, Belaiche D, Kouach M, et al. Critical role of tyrosine 277 in the ligand-binding and transactivating properties of retinoic acid receptor alpha. Biochemistry. 2000;39(18):5622doi: 10.1021/bi005107d.
Mailfait, S., Belaiche, D., Kouach, M., Dallery, N., Chavatte, P., Formstecher, P., & Sablonniere, B. (2000). Critical role of tyrosine 277 in the ligand-binding and transactivating properties of retinoic acid receptor alpha. Biochemistry, 39(18), 5622. https://doi.org/10.1021/bi005107d
Mailfait, et al. "Critical role of tyrosine 277 in the ligand-binding and transactivating properties of retinoic acid receptor alpha." Biochemistry vol. 39,18 (2000): 5622. doi: https://doi.org/10.1021/bi005107d
Mailfait S, Belaiche D, Kouach M, Dallery N, Chavatte P, Formstecher P, Sablonniere B. Critical role of tyrosine 277 in the ligand-binding and transactivating properties of retinoic acid receptor alpha. Biochemistry. 2000 May 09;39(18):5622. doi: 10.1021/bi005107d. PMID: 10820036.
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Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors.

International journal of oncology

Ferrari N, Tonini G, Briata A, Bottini F, Vidali G.
PMID: 21559674
Int J Oncol. 1994 Nov;5(5):1019-22. doi: 10.3892/ijo.5.5.1019.

The expression of alpha, beta and gamma retinoic acid receptors (RAR) was analyzed by reverse transcription polymerase chain reaction (RT/PCR) in several neuroblastoma derived cell lines before and after exposure to 10 nM retinoic acid. Each cell line shows...

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Ferrari N, Tonini G, Briata A, et al. Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors. Int J Oncol. 1994;5(5):1019-22doi: 10.3892/ijo.5.5.1019.
Ferrari, N., Tonini, G., Briata, A., Bottini, F., & Vidali, G. (1994). Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors. International journal of oncology, 5(5), 1019-22. https://doi.org/10.3892/ijo.5.5.1019
Ferrari, N, et al. "Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors." International journal of oncology vol. 5,5 (1994): 1019-22. doi: https://doi.org/10.3892/ijo.5.5.1019
Ferrari N, Tonini G, Briata A, Bottini F, Vidali G. Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors. Int J Oncol. 1994 Nov;5(5):1019-22. doi: 10.3892/ijo.5.5.1019. PMID: 21559674.
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Pivotal regulatory network and genes in osteosarcoma.

Archives of medical science : AMS

Luo Y, Deng Z, Chen J.
PMID: 23847684
Arch Med Sci. 2013 Jun 20;9(3):569-75. doi: 10.5114/aoms.2012.30956. Epub 2012 Oct 08.

INTRODUCTION: Understanding the transcriptional regulatory networks that map out the coordinated responses of transcription factors and target genes would represent a significant advance in the analysis of osteosarcoma, a common primary bone malignancy. The objective of our study was...

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Luo Y, Deng Z, Chen J. Pivotal regulatory network and genes in osteosarcoma. Arch Med Sci. 2012;9(3):569-75doi: 10.5114/aoms.2012.30956.
Luo, Y., Deng, Z., & Chen, J. (2013). Pivotal regulatory network and genes in osteosarcoma. Archives of medical science : AMS, 9(3), 569-75. https://doi.org/10.5114/aoms.2012.30956
Luo, Yi, et al. "Pivotal regulatory network and genes in osteosarcoma." Archives of medical science : AMS vol. 9,3 (2013): 569-75. doi: https://doi.org/10.5114/aoms.2012.30956
Luo Y, Deng Z, Chen J. Pivotal regulatory network and genes in osteosarcoma. Arch Med Sci. 2013 Jun 20;9(3):569-75. doi: 10.5114/aoms.2012.30956. Epub 2012 Oct 08. PMID: 23847684; PMCID: PMC3701964.
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Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature.

Journal of community hospital internal medicine perspectives

MacDougall K, Chukkalore D, Rehan M, Kashi M, Bershadskiy A.
PMID: 34804401
J Community Hosp Intern Med Perspect. 2021 Nov 15;11(6):832-838. doi: 10.1080/20009666.2021.1973657. eCollection 2021.

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation of chromosomes 15 and 17, creating an alternation in the retinoic acid receptor-alpha (RAR-alpha) gene. This leads to excessive medullary production of promyelocytic...

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MacDougall K, Chukkalore D, Rehan M, et al. Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature. J Community Hosp Intern Med Perspect. 2021;11(6):832-838doi: 10.1080/20009666.2021.1973657.
MacDougall, K., Chukkalore, D., Rehan, M., Kashi, M., & Bershadskiy, A. (2021). Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature. Journal of community hospital internal medicine perspectives, 11(6), 832-838. https://doi.org/10.1080/20009666.2021.1973657
MacDougall, Kira, et al. "Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature." Journal of community hospital internal medicine perspectives vol. 11,6 (2021): 832-838. doi: https://doi.org/10.1080/20009666.2021.1973657
MacDougall K, Chukkalore D, Rehan M, Kashi M, Bershadskiy A. Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature. J Community Hosp Intern Med Perspect. 2021 Nov 15;11(6):832-838. doi: 10.1080/20009666.2021.1973657. eCollection 2021. PMID: 34804401; PMCID: PMC8604466.
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Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices.

Aquatic toxicology (Amsterdam, Netherlands)

Ometere Boyi J, Stokholm I, Hillmann M, Søndergaard J, Persson S, de Wit CA, Siebert U, Kristina L.
PMID: 34856463
Aquat Toxicol. 2021 Nov 15;242:106035. doi: 10.1016/j.aquatox.2021.106035. Epub 2021 Nov 15.

Ringed seals (Pusa hispida) are slowly recovering in the eastern and northern parts of the Baltic Sea after years of hunting pressure and contaminant exposure. Still, consequences of anthropogenic activities such as contaminant exposure and increasing temperatures are stressors...

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Ometere Boyi J, Stokholm I, Hillmann M, et al. Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices. Aquat Toxicol. 2021;242:106035doi: 10.1016/j.aquatox.2021.106035.
Ometere Boyi, J., Stokholm, I., Hillmann, M., Søndergaard, J., Persson, S., de Wit, C. A., Siebert, U., & Kristina, L. (2021). Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices. Aquatic toxicology (Amsterdam, Netherlands), 242106035. https://doi.org/10.1016/j.aquatox.2021.106035
Ometere Boyi, Joy, et al. "Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices." Aquatic toxicology (Amsterdam, Netherlands) vol. 242 (2021): 106035. doi: https://doi.org/10.1016/j.aquatox.2021.106035
Ometere Boyi J, Stokholm I, Hillmann M, Søndergaard J, Persson S, de Wit CA, Siebert U, Kristina L. Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices. Aquat Toxicol. 2021 Nov 15;242:106035. doi: 10.1016/j.aquatox.2021.106035. Epub 2021 Nov 15. PMID: 34856463.
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The promyelocytic leukemia zinc finger protein: two decades of molecular oncology.

Frontiers in oncology

Suliman BA, Xu D, Williams BR.
PMID: 22822476
Front Oncol. 2012 Jul 17;2:74. doi: 10.3389/fonc.2012.00074. eCollection 2012.

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA gene encoding retinoic...

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Suliman BA, Xu D, Williams BR. The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Front Oncol. 2012;2:74doi: 10.3389/fonc.2012.00074.
Suliman, B. A., Xu, D., & Williams, B. R. (2012). The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Frontiers in oncology, 274. https://doi.org/10.3389/fonc.2012.00074
Suliman, Bandar Ali, et al. "The promyelocytic leukemia zinc finger protein: two decades of molecular oncology." Frontiers in oncology vol. 2 (2012): 74. doi: https://doi.org/10.3389/fonc.2012.00074
Suliman BA, Xu D, Williams BR. The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Front Oncol. 2012 Jul 17;2:74. doi: 10.3389/fonc.2012.00074. eCollection 2012. PMID: 22822476; PMCID: PMC3398472.
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Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq.

Nucleic acids research

Glaser LV, Steiger M, Fuchs A, van Bömmel A, Einfeldt E, Chung HR, Vingron M, Meijsing SH.
PMID: 34850108
Nucleic Acids Res. 2021 Dec 02;49(21):12178-12195. doi: 10.1093/nar/gkab1100.

Embryonic stem cells (ESCs) can differentiate into any given cell type and therefore represent a versatile model to study the link between gene regulation and differentiation. To quantitatively assess the dynamics of enhancer activity during the early stages of...

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Glaser LV, Steiger M, Fuchs A, et al. Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Nucleic Acids Res. 2021;49(21):12178-12195doi: 10.1093/nar/gkab1100.
Glaser, L. V., Steiger, M., Fuchs, A., van Bömmel, A., Einfeldt, E., Chung, H. R., Vingron, M., & Meijsing, S. H. (2021). Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Nucleic acids research, 49(21), 12178-12195. https://doi.org/10.1093/nar/gkab1100
Glaser, Laura V, et al. "Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq." Nucleic acids research vol. 49,21 (2021): 12178-12195. doi: https://doi.org/10.1093/nar/gkab1100
Glaser LV, Steiger M, Fuchs A, van Bömmel A, Einfeldt E, Chung HR, Vingron M, Meijsing SH. Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Nucleic Acids Res. 2021 Dec 02;49(21):12178-12195. doi: 10.1093/nar/gkab1100. PMID: 34850108; PMCID: PMC8643627.
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A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review.

OncoTargets and therapy

Liu Y, Xu F, Hu H, Wen J, Su J, Zhou Q, Qu W.
PMID: 31447564
Onco Targets Ther. 2019 Aug 02;12:6157-6163. doi: 10.2147/OTT.S217622. eCollection 2019.

BACKGROUND: Acute promyelocytic leukemia (APL) is commonly characterized by the fusion of retinoic acid receptor alpha (RARA) with promyelocytic leukemia (PML). Most APL patients acquire long-term survival after treatment with all-trans retinoic acid (ATRA) or arsenic agents-based chemotherapy.CASE PRESENTATION:...

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Liu Y, Xu F, Hu H, et al. A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review. Onco Targets Ther. 2019;12:6157-6163doi: 10.2147/OTT.S217622.
Liu, Y., Xu, F., Hu, H., Wen, J., Su, J., Zhou, Q., & Qu, W. (2019). A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review. OncoTargets and therapy, 126157-6163. https://doi.org/10.2147/OTT.S217622
Liu, Yiping, et al. "A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review." OncoTargets and therapy vol. 12 (2019): 6157-6163. doi: https://doi.org/10.2147/OTT.S217622
Liu Y, Xu F, Hu H, Wen J, Su J, Zhou Q, Qu W. A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review. Onco Targets Ther. 2019 Aug 02;12:6157-6163. doi: 10.2147/OTT.S217622. eCollection 2019. PMID: 31447564; PMCID: PMC6684484.
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Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy.

Cancers

Martino OD, Welch JS.
PMID: 31805753
Cancers (Basel). 2019 Dec 01;11(12). doi: 10.3390/cancers11121915.

Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and RXRs) are ligand-dependent transcription factors. All-trans retinoic acid (ATRA) is the principal endogenous ligand for the retinoic acid...

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Martino OD, Welch JS. Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. Cancers (Basel). 2019;11(12)doi: 10.3390/cancers11121915.
Martino, O. D., & Welch, J. S. (2019). Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. Cancers, 11(12), . https://doi.org/10.3390/cancers11121915
Martino, Orsola di, and Welch, John S. "Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy." Cancers vol. 11,12 (2019). doi: https://doi.org/10.3390/cancers11121915
Martino OD, Welch JS. Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. Cancers (Basel). 2019 Dec 01;11(12). doi: 10.3390/cancers11121915. PMID: 31805753; PMCID: PMC6966485.
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