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Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies.

The American journal of psychiatry

Frank P, Jokela M, Batty GD, Cadar D, Steptoe A, Kivimäki M.
PMID: 34645276
Am J Psychiatry. 2021 Dec;178(12):1107-1118. doi: 10.1176/appi.ajp.2021.20121776. Epub 2021 Oct 14.

OBJECTIVE: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between systemic inflammation and an array of individual...

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.

Nature communications

Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C.
PMID: 34675202
Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z.

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same...

Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

International journal of obesity (2005)

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C.
PMID: 33446837
Int J Obes (Lond). 2021 Apr;45(4):758-765. doi: 10.1038/s41366-020-00735-9. Epub 2021 Jan 14.

BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed...

Showing 1 to 3 of 3 entries