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Showing 1 to 12 of 27 entries
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An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.

The Journal of experimental medicine

Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Martinez AR, Miles B, Farias E, Mezei M, Nobre AR, Singh D, Kale N, Sproll KC, Sosa MS, Aguirre-Ghiso JA.
PMID: 34812843
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20210836. Epub 2021 Nov 23.

We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy...

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21.

Oncotarget

Mei AH, Tung K, Han J, Perumal D, Laganà A, Keats J, Auclair D, Chari A, Jagannath S, Parekh S, Cho HJ.
PMID: 32133047
Oncotarget. 2020 Feb 18;11(7):727-739. doi: 10.18632/oncotarget.27488. eCollection 2020 Feb 18.

The type I Melanoma Antigen Gene (MAGE) A3 is a functional target associated with survival and proliferation in multiple myeloma (MM). To investigate the mechanisms of these oncogenic functions, we performed gene expression profiling (GEP) of p53 wild-type human...

Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of .

Frontiers in cell and developmental biology

Papa L, Djedaini M, Martin TC, Zangui M, Beaumont KG, Sebra R, Parsons R, Schaniel C, Hoffman R.
PMID: 33384995
Front Cell Dev Biol. 2020 Dec 15;8:592348. doi: 10.3389/fcell.2020.592348. eCollection 2020.

No abstract available.

Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.

Journal of the National Cancer Institute

Kerns SL, Fachal L, Dorling L, Barnett GC, Baran A, Peterson DR, Hollenberg M, Hao K, Narzo AD, Ahsen ME, Pandey G, Bentzen SM, Janelsins M, Elliott RM, Pharoah PDP, Burnet NG, Dearnaley DP, Gulliford SL, Hall E, Sydes MR, Aguado-Barrera ME, Gómez-Caamaño A, Carballo AM, Peleteiro P, Lobato-Busto R, Stock R, Stone NN, Ostrer H, Usmani N, Singhal S, Tsuji H, Imai T, Saito S, Eeles R, DeRuyck K, Parliament M, Dunning AM, Vega A, Rosenstein BS, West CML.
PMID: 31095341
J Natl Cancer Inst. 2020 Feb 01;112(2):179-190. doi: 10.1093/jnci/djz075.

BACKGROUND: A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.METHODS: We conducted an individual patient...

ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs.

Journal of neuroscience methods

Barretto N, Zhang H, Powell SK, Fernando MB, Zhang S, Flaherty EK, Ho SM, Slesinger PA, Duan J, Brennand KJ.
PMID: 32065989
J Neurosci Methods. 2020 Feb 14;334:108548. doi: 10.1016/j.jneumeth.2019.108548. Epub 2020 Feb 14.

BACKGROUND: Somatic cell reprogramming is routinely used to generate donor-specific human induced pluripotent stem cells (hiPSCs) to facilitate studies of disease in a human context. The directed differentiation of hiPSCs can generate large quantities of patient-derived cells; however, such...

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.

The Journal of experimental medicine

Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Martinez AR, Miles B, Farias E, Mezei M, Nobre AR, Singh D, Kale N, Sproll KC, Sosa MS, Aguirre-Ghiso JA.
PMID: 34812843
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20210836. Epub 2021 Nov 23.

We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy...

Genetic pleiotropy of ERCC6 loss-of-function and deleterious missense variants links retinal dystrophy, arrhythmia, and immunodeficiency in diverse ancestries.

Human mutation

Forrest IS, Chaudhary K, Vy HMT, Bafna S, Kim S, Won HH, Loos RJF, Cho J, Pasquale LR, Nadkarni GN, Rocheleau G, Do R.
PMID: 34005834
Hum Mutat. 2021 Aug;42(8):969-977. doi: 10.1002/humu.24220. Epub 2021 May 31.

Biobanks with exomes linked to electronic health records (EHRs) enable the study of genetic pleiotropy between rare variants and seemingly disparate diseases. We performed robust clinical phenotyping of rare, putatively deleterious variants (loss-of-function [LoF] and deleterious missense variants) in...

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.

The Journal of experimental medicine

Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, Martinez AR, Miles B, Farias E, Mezei M, Nobre AR, Singh D, Kale N, Sproll KC, Sosa MS, Aguirre-Ghiso JA.
PMID: 34812843
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20210836. Epub 2021 Nov 23.

We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy...

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing.

bioRxiv : the preprint server for biology

Cohen P, DeGrace EJ, Danziger O, Patel RS, Rosenberg BR.
PMID: 34845443
bioRxiv. 2021 Nov 24; doi: 10.1101/2021.11.22.469642.

Single cell RNA sequencing (scRNAseq) studies have provided critical insight into the pathogenesis of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), the causative agent of COronaVIrus Disease 2019 (COVID-19). scRNAseq workflows are generally designed for the detection and quantification...

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.

Cancer discovery

Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigí M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Cañadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Jänne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA.
PMID: 33707236
Cancer Discov. 2021 Aug;11(8):1952-1969. doi: 10.1158/2159-8290.CD-20-0913. Epub 2021 Mar 11.

Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uniquely upregulates...

Breast Cancer, Alzheimer's Disease, and .

Journal of Alzheimer's disease reports

Lehrer S, Rheinstein PH.
PMID: 33681716
J Alzheimers Dis Rep. 2021 Jan 20;5(1):49-53. doi: 10.3233/ADR-200266.

BACKGROUND: Cognitive problems are common in breast cancer patients. The apolipoprotein E4 (OBJECTIVE: To further evaluate the effects of the METHODS: Our analysis included all subjects with invasive breast cancer. Single nucleotide polymorphism (SNP) data for rs 429358 and...

Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells.

Nature aging

Navarro E, Udine E, de Paiva Lopes K, Parks M, Riboldi G, Schilder BM, Humphrey J, Snijders GJL, Vialle RA, Zhuang M, Sikder T, Argyrou C, Allan A, Chao MJ, Farrell K, Henderson B, Simon S, Raymond D, Elango S, Ortega RA, Shanker V, Swan M, Zhu CW, Ramdhani R, Walker RH, Tse W, Sano M, Pereira AC, Ahfeldt T, Goate AM, Bressman S, Crary JF, de Witte L, Frucht S, Saunders-Pullman R, Raj T.
PMID: 35005630
Nat Aging. 2021 Sep;1(9):850-863. doi: 10.1038/s43587-021-00110-x. Epub 2021 Sep 14.

An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesize that PD susceptibility genes modulate disease risk by influencing gene expression...

Showing 1 to 12 of 27 entries